Browsing by Author "Priyadharshini, IK"

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    Immunohistochemical Expression of BCl2 Oncoprotein in Varying Histological Grades of Oral Squamous Cell Carcinoma.
    (Light House Polyclinic, 2025-03) Subhalakshmi, V; Jaiswal, R; Priyadharshini, IK; Ambika, M
    Oral cancer has been rising in alarming numbers in the world which is anticipated to escalate at 70% by 2030. Although a lot of factors are responsible for the disease, genetics, and gene mutations play a major role in uncontrolled proliferation. Another major factor is apoptosis which is programmed cell death. Apoptosis generally happens in two pathways Extrinsic pathway which involves trans-membrane receptor-mediated interaction and by Intrinsic pathway which is a mitochondrial-initiated event. There are Pro-apoptotic genes that support apoptosis like Caspases, TNF, and P53 families, and Anti-apoptotic genes like BCL-2 which stop the programmed cell death leading to cellular proliferation and tumor progression. This study was done to find the role of the anti-apoptotic protein BCL2 in varying histological grades of oral squamous cell carcinoma by immunohistochemistry.