Browsing by Author "Prajapati, C"

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    DiSi Survey: Use of Generic DPP4i–SGLT2i Fixed-dose Combinations in Indian Clinical Practice
    (Journal of Indian Medical Association, 2024-12) Saboo, B; Prajapati, C; Muralidharan, P; Qamra, A.
    India has a high burden of patients with diabetes mellitus (DM). Challenges to managing type 2 diabetes (T2DM) in India are unique. Indian T2DM patients do not just present with DM alone, but with clustering of cardiovascular (CV) risk factors like hypertension (HTN), dyslipidemia, and obesity. Furthermore, Indian patients also have lesser baseline beta-cell function compared to global reference populations. In India, various cost-effective, generic, fixed-dose combinations (FDC) of dipeptidyl peptidase 4 inhibitors (DPP4i) with sodium-glucose cotransporter 2 inhibitors (SGLT2i) are available for the management of T2DM. However, to the best of our knowledge, scant surveys have studied the clinical practice nuances regarding the use of these FDCs in Indian settings. Hence, we designed and conducted a knowledge, attitude, and practice (KAP) survey to study the attitude and practice of Indian physicians with regard to patient population and placement of generic DPP4i–SGLT2i FDCs. Our survey showed that in India, patients often present with a high baseline HbA1c. From a glycaemic control perspective, DPP4i-SGLT2i FDCs are preferred in treatment-naïve patients with HbA1c >8% and those with HbA1c >8.5% despite metformin monotherapy. Also, 85% physicians observed a reduction in SGLT2i associated GUTIs with use of DPP4i-SGLT2i FDCs or concomitant use of these agents. Part of these survey findings were presented at the American Diabetes Association (ADA) 2024 Congress held in Orlando, Florida.
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    Olmesartan: 360-degree Perspectives Befitting an Angiotensin Receptor Blocker
    (Journal of Indian Medical Association, 2024-12) Shetty, S; Bhoraskar, A; Saboo, B; Routray, S; Tiwaskar, M; Sreenivasamurthy, L; Shrivas, VK; Jose, A; Prajapati, C; Qamra, A; Muralidharan, P.
    India has a high burden of hypertension (HTN), which is often poorly controlled, leading to hypertension-mediated organ damage (HMOD). In the management of HTN, angiotensin receptor blockers (ARBs) assume prime importance, being first-line agents for most patient subgroups. Olmesartan is a highly efficacious ARB that demonstrates sustained blood pressure (BP) reduction over 24 hours. Moreover, it also assumes a protective role by reducing microvascular inflammation, left ventricular hypertrophy, proteinuria, vascular stiffness, central aortic BP, cardiocerebrovascular events and atrial fibrillation. To enhance therapeutic compliance and achieve BP goals, single- pill combinations with other antihypertensive agents are also available. This review holistically summarizes the evidence of olmesartan for HTN management for not only BP reduction but also organoprotective effects.
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    Optimizing the Process Parameters for Carrot Cake Development Using Response Surface Methodology
    (Ms. M. B. Mondal, 2024-09) Prajapati, C; Kamaliya, K; Dhingani, R.
    Carrots (Daucus carota L.) are rich in vitamins B1, B2, B6, ?-carotene, and dietary fibers, having nutritional benefits such as, antioxidant, and anticancer properties. Carrot offers a valuable nutritional boost for enhancing bakery products. Incorporating carrot into cake preparation not only adds a unique flavor and moist texture but also boosts the nutritional value with additional vitamins and fiber. The research systematically examines the effects of varying process parameters such as carrot, sweetened condensed milk, and whey protein concentrate (WPC) on specific volume, springiness, and overall acceptability of carrot cake using Central Composite Design (CCD) of Response Surface Methodology (RSM). The optimal formulation for carrot cake consisted of 70.8 g of carrot, 200 g of sweetened condensed milk, and 4.2 g of WPC. This combination resulted in a high-quality carrot cake with a specific volume of 2.58 cm�/g, a springiness measurement of 1.049 mm, and an overall acceptability rating of 8.3. This approach not only enhances product quality but also supports waste reduction by valorizing carrot, aligning with sustainable food processing practices.
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    A Retrospective Analysis of 2 Years of Faciomaxillary Injuries in Patients Treated at Various Regional Centers in Gujarat
    (International Research Organization for Life & Health Sciences, 2023-07) Kachadia, N; Prajapati, C; Soni, SK; Guguloth, D; Gothwal, S; Vanzara, D; Kadia, R
    Introduction: The incidence of faciomaxillary injuries is on the rise due to motor vehicle accidents and increased incidenceof violence in recent times. The aim of this retrospective study was to determine the incidence, etiology, and the pattern offractures in the faciomaxillary region.Materials and Methods: After obtaining permission from the concerned authorities, a predesigned questionnaire was used tocollect the necessary data from the department. Aretrospective analysis of 1087 patients who suffered trauma and were managedin the Department of Burns and Plastic Surgery in three regional centers in Gujarat over a period of 2 years was carried out.Results: Road traffic accident (RTA) was the common cause of faciomaxillary injuries. Men sustained more injuries as comparedto women. Injuries were most commonly sustained in the age group of 11–40 years, constituting about 76% of all injuries,mandibular fractures were the most common.Conclusion: RTAs were the most common cause for the faciomaxillary injuries