Browsing by Author "Pezzuto, J M"
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Item A sensitive assay for anti-HIV-1 drug discovery in a biological safety level-2 laboratory.(1998-12-20) Yoosook, C; Reutrakul, V; Santisuk, T; Chaichana, S; Pezzuto, J M; Dong, Y; Clanton, D J; Kiser, R; Staley, PStudies involving infectious, wild type HIV-1 must be performed under strict BSL-3 practice. We have employed a defective (deltaTat/Rev)MC99 and cloned 1A2 line, ie, mutated HIV-1 and Tat/Rev transfected cells to verify anti-HIV-1 activity in a BSL-2 laboratory. A number of extracts from various parts of 11 species of plants were studied. Results were correlated with those of an anti-HIV-1 reverse transcriptase (RT) assay.