Browsing by Author "Patil, Prachi"

Now showing 1 - 11 of 11
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    A clinical study of preterm labour
    (Medip Academy, 2019-11) Patil, Prachi; Singh, Richa; Gopal, Sriram
    Background: There has been a rising incidence of preterm labour in India. Preterm labour poses greater risks of morbidity and mortality of the preterm neonates. Various factors contribute towards risk of preterm labour and its outcome. Addressing these factors appropriately improves the outcome in pregnant women.Methods: This prospective observational study was conducted in department of obstetrics and gynaecology from the period of July 2017 to July 2018.Results: The present study was in 98 patients admitted in our hospital with preterm labour. Clinical profile of those patients was studied. Statistically significant association was found between administration of antibiotics and tocolysis in prolongation of pregnancy (p value=0.00). There was an association found between gestational age at birth and immediate neonatal outcome (p value=0.00). Preterm labour was more common in multigravidae (62.4%) and women with cervical length less than 3 cm (85.17%).Conclusions: Preterm labour can be expected more commonly in multigravidae, pregnant women with cervical length less than 3 cm and in presence of high-risk factors. Anticipation of preterm labour, judicious use of antibiotics, tocolytics can improve the outcome of preterm labour.
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    Gastroenterology elsewhere.
    (2009-01) Patil, Prachi; Shukla, Akash
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    Gastroenterology elsewhere.
    (2009-05) Patil, Prachi; Shah, Sundeep
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    Gastroenterology elsewhere.
    (2009-09) Patil, Prachi; Shah, Sundeep
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    Gastroenterology Elsewhere.
    (2009-11) Patil, Prachi; Shah, Sundeep
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    Gastroenterology Elsewhere.
    (2010-03) Patil, Prachi; Shah, Sundeep
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    Head and neck squamous cell carcinoma in HIV, HBV and HCV seropositive patients - Prognosis and its predictors
    (Wolters Kluwer India Pvt. Ltd., 2020-07) Nayyar, Supreet Singh; Thiagarajan, Shivakumar; Malik, Akshat; D'Cruz, Anil; Chaukar, Devendra; Patil, Prachi; Alahari, Aruna Dhir; Lashkar, Sarbani Ghosh; Kumar, Prabhash
    Introduction: Patients receiving treatment for head-and-neck squamous cell carcinoma (HNSCC) also may have coexisting viral infections caused by HIV, HBV, and HCV (seropositive). There is scarce literature regarding the clinical presentation and treatment outcomes for these patients with coexisting viral infections (seropositive HNSCC). We conducted this study to assess the clinical presentation and treatment outcomes (overall survival [OS] and disease-specific survival [DSS]) of seropositive HNSCC patients. Methodology: This was a retrospective cohort study on seropositive HNSCC patients registered at our center from 2012 to 2014. The viral infections were identified by the presence of the antibodies to these viruses in the patient's blood samples. Results: Out of the 19,137 HNSCC patients registered, 156 patients had HBV, HCV, and/or HIV infection. Among these, HBV infection was the most common (n = 86/156, 55.1%) followed by HIV infection (n = 36/156, 23.1%) and HCV infection (n = 29/156, 18.6%). The oral cavity was the most common subsite involved. Majority of these patients presented at an advanced stage (advanced T stage – 71.8% and node positive – 62.2%). The majority of the patients received curative-intent treatment (65.4%). The OS at 3 years for these HNSCC patients with coexisting HIV, HBV, and HCV infection was 60%, 62.6%, and 57.5%, respectively, and their DSS at 3 years was 58.8%, 78.6%, and 53.8%, respectively. Conclusions: Seropositive patients with HNSCC often present in the advanced stage but have a good survival if treated appropriately
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    Incidence of depression in pregnant and postpartum women in tertiary care hospital using Edinburg postpartum depression scale: A prospective observational clinical study
    (Wolters Kluwer – Medknow, 2024-01) More, Mayuri; Agarwal, Aashna; Noorien, Ruma; Shetty, Chiranjeev; Gopal, Sriram; Patil, Prachi
    Background: Depression is a mood disorder characterized by physical symptoms like fatigue, pain, sleep disturbances, and/or a persistently low mood. Antenatal depression refers to a nonpsychotic depressive condition that starts during pregnancy. Postpartum depression, on the other hand, emerges within a month after childbirth and can persist for up to 1 year. The objective of this study is to determine the occurrence of depression among women during both the antenatal and postnatal periods by utilizing the Edinburgh Postnatal Depression Scale (EPDS). Materials and Methods: From 1 August 2022 to 1 September 2023, 246 women responded to the EPDS questionnaire during and after childbirth. Valid consent was obtained from all participating subjects before the study’s commencement. Results: The study revealed that depressive disorders affected 23.2% of women during the antenatal period and 20.3% during the postnatal phase. A higher prevalence of depression was observed among multiparous women (53.7%) and those aged between 25 and 34 years (64.2%). Additionally, significant associations between depression and risk factors like cesarean delivery (54.1%) were identified. Conclusion: Both the postpartum period and pregnancy pose increased risks for the onset of various psychiatric disorders. This research assisted in screening, classifying, and identifying high-risk individuals and providing guidance and support to those requiring additional assistance and counseling. Therefore, regular EPDS screening can potentially enhance maternal and child health outcomes.
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    Management of colon cancer at a tertiary referral center in India - Patterns of presentation, treatment, and survival outcomes
    (Indian Cancer Society, 2019-10) Noronha, Jarin; deSouza, Ashwin; Patil, Prachi; Mehta, Shaesta; Engineer, Reena; Ostwal, Vikas; Ramaswamy, Anant; Ankathi, Suman K; Ramadwar, Mukta; Saklani, Avanish
    AIM: To define the patterns of disease presentation, treatment strategies, and outcomes for patients with colon cancer at a tertiary referral center in India over 1 year period. MATERIALS AND METHODS: This is a retrospective analysis of a prospectively maintained database. All consecutive patients with proven or suspected colonic adenocarcinoma between July 2013 and July 2014 were evaluated in a dedicated analysed multidisciplinary clinic at the Tata Memorial Hospital, Mumbai. The demography, treatment plan, pathology, stage, and survival data were examined. RESULTS: The median age of presentation was 49 years with 60.1% male patients. In total, 151 cases (57.4%) underwent treatment with curative intent consisting of surgery with adjuvant chemotherapy as indicated. The rest were offered either palliative chemotherapy (36.9%) or best supportive care (5.7%). Approximately, 70% patients had advanced stage disease (Stage III/IV) at presentation and 41.8% presented with metastatic disease with the liver being the most common site of disease dissemination. With a median follow-up of 29 months, the estimated 3-year disease free survival for patients treated with curative intent was 67.1%. The median progression free survival was 12.3 months for patients treated with palliative intent. The estimated 3-year overall survival was 89.7%, 65.5%, and 22.8% for Stage I/II, Stage III, and Stage IV, respectively. CONCLUSION: Indian patients with colon cancer, at a tertiary referral center, tend to present at more advanced stages of the disease as compared to the West. However, curative treatment with surgery and chemotherapy offers similar survival outcomes when compared stage for stage
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    Non-operative management in low-lying rectal cancers undergoing chemoradiation
    (Wolters Kluwer - Medknow, 2024-01) Datta, Debanjali; Engineer, Reena; Saklani, Avanish; D’souza, Ashwin; Baheti, Akshay; Kumar, Suman; Krishnatry, Rahul; Ostwal, Vikas; Ramaswamy, Anant; Patil, Prachi
    Purpose: To evaluate the outcomes of post?neoadjuvant chemoradiation (NACTRT) wait?and?watch Strategy (WWS) in distal rectal cancers. Materials and Methods: All consecutive patients from December 2012 to 2019 diagnosed with distal rectal tumors (T2?T4 N0?N+) having a complete or near?complete response (cCR or nCR, respectively) post?NACTRT and wishing for the non?surgical treatment option of WWS were included in this study. Patients were observed with 3 monthly magnetic resonance imaging (MRIs), sigmoidoscopies, and digital rectal examination for 2 years and 6 monthly thereafter. Organ preservation rate (OPR), local regrowth rate (LRR), non?regrowth recurrence?free survival (NR?RFS) and overall survival (OAS) were estimated using the Kaplan–Meier method, and factors associated with LRR were identified on univariate and multivariate analysis using the log?rank test (P < 0.05 significant). Results: Sixty?one consecutive patients post?NACTRT achieving cCR[44 (72%)] and nCR[17 (28%)], respectively, were identified. All patients received pelvic radiotherapy at a dose of 45–50Gy conventional fractionation and concurrent capecitabine. An additional boost dose with either an external beam or brachytherapy was given to 39 patients. At a median follow?up of 39 months, 11 (18%) patients had local regrowth, of which seven were salvaged with surgery and the rest are alive with the disease, as they refused surgery. The overall OPR, NR?RFS, and OS were 83%, 95%, and 98%, respectively. Seven (11%) patients developed distant metastasis, of which six underwent metastatectomy and are alive and well. LRR was higher in patients with nCR versus cCR (P = 0.05). Conclusion: The WWS is a safe non?operative alternative management for selected patients attaining cCR/nCR after NACTRT with excellent outcomes.
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    Predictors of toxicity after neoadjuvant chemoradiotherapy for locally advanced gall bladder cancer
    (Wolters Kluwer - Medknow, 2022-09) Loyal, Anushree; Chopra, Supriya; Goel, Mahesh; Mehta, Shaesta; Patil, Prachi; Patkar, Shraddha; Shrivastava, Shyam; Engineer, Reena
    Background: The present study evaluated the correlation of hepatobiliary toxicity and radiation dose received in patients undergoing neoadjuvant chemoradiotherapy (NACRT) for locally advanced unresectable gall bladder cancers (LAGBC). Methods: Twenty-six patients with LAGBC, treated with NACRT (55–57 Gy/25 fractions/5 weeks and weekly gemcitabine 300 mg/m2) within a phase II study, were included. Whenever feasible, surgery was performed after NACRT. Acute and late hepatobiliary toxicity was recorded. Treatment scans were retrieved to delineate central porto-hepatobiliary system (CPHBS), resected liver surface, segment IV B and V, and duodenum. The doses received by these structures were recorded and correlated with toxicity. Results: Of 26 patients, 20 (77%) had partial or complete response and 12 (46%) had R0 resection. At the median follow-up of 38 months, overall survival was 38%. Eight (30%) patients had post-treatment toxicity, of which most common was biliary toxicity (30%). A correlation was observed between the biliary leak and V45Gy CPHBS >50 cm3 (P = 0.070). Higher toxicity was observed in those with metallic stents (P = 0.072). Conclusion: The incidence of the biliary leak was 46%. CPHBS dose was found to correlate with biliary leaks. Restricting V45Gy CPHBS <50 cm3 and using plastic stent may facilitate a reduction in hepatobiliary toxicity in patients undergoing NACRT and surgery.