Browsing by Author "Pati, H"

Now showing 1 - 20 of 21
  • No Thumbnail Available
    Item
    Acute leukemia in children.
    (1988-08-01) Choudhry, V P; Arya, L S; Marwaha, R K; Pati, H; Saraya, A K
  • No Thumbnail Available
    Item
    Anti-D immunoglobulin in the treatment of idiopathic thrombocytopenic purpura.
    (1994-03-01) Krishnamurti, L; Charan, V D; Desai, N; Pati, H; Choudhry, V P
    Anti-D was evaluated in 8 RhD positive patients (6 males, 2 females) aged 2-21 years (mean 10 years) with Idiopathic Thrombocytopenic Purpura (ITP). Five patients with chronic ITP and 3 patients with acute ITP were administered Anti-D in the dosage of 50 micrograms/kg intramuscularly (IM) for 3 consecutive days. One patient of chronic ITP received two courses of Anti-D. Patients were followed up for 7 to 16 months (mean 9 months). All three cases of acute ITP had a complete response and are in remission between 3 to 12 months of follow up. Two of five cases of chronic ITP had a partial response. Rise in platelet count was observed within 72-124 hours, and duration of response varied between 10 to 15 days. None of these patients had any significant side effects of anti-D immunoglobulin therapy. Intramuscular administration of Anti-D is safe, effective and low cost alternative to IVIgG in the treatment of acute ITP.
  • No Thumbnail Available
    Item
    Atypical features of primary myelodysplastic syndrome.
    (1986-11-01) Pati, H; Bhargava, M; Kochupillai, V
  • No Thumbnail Available
    Item
    Camurati-Engelmann disease with recurrent bone marrow hypoplasia.
    (1985-03-01) Moudgil, A; Agarwal, R K; Pati, H; Bagga, A; Saraya, A K
  • No Thumbnail Available
    Item
    Causes of mortality in children with acute lymphocytic leukemia.
    (1992-06-01) Choudhry, V P; Krishnamurthy, L; Arya, L S; Desai, N; Pati, H
    Fifty five deaths between January, 1982 to September, 1989 in children with acute lymphoblastic leukemia (ALL) were evaluated to determine the cause of mortality. Fifty cases died during remission. Infection alone was responsible for death in 26 of 55 (47.3%) cases while hemorrhage was seen in 7 (12.7%) children. Infection and hemorrhage together were responsible in another 13 cases. Gastrointestinal tract and pulmonary system were the major sites of bleeding. Infections either alone or in combination with other factors were responsible for death in 42 of 55 (76.5%) of children. Septicemia (n = 11), gastrointestinal (n = 15) and pulmonary infections (n = 10) and meningitis in 2 cases were the major sites of infections. Pseudomonas and Klebsiella in 6 cases each accounted for 54.5% of isolates.
  • No Thumbnail Available
    Item
    Coagulation factor and platelet defect.
    (1987-02-01) Pati, H; Saraya, A K
  • No Thumbnail Available
    Item
    Congenital dyserythropoietic anemia, type II (HEMPAS).
    (1986-05-01) Pati, H; Arya, L S; Puri, S; Saraya, A K
  • No Thumbnail Available
    Item
    Congenital pure red cell aplasia in northern India.
    (1985-01-01) Agarwal, R K; Moudgil, A; Pati, H; Bagga, A; Choudhry, V P; Saraya, A K
  • No Thumbnail Available
    Item
    Efficacy of intrathecal methotrexate with and without cranial radiotherapy in preventing central nervous system relapses in acute lymphocytic leukemia.
    (1992-07-01) Choudhry, V P; Krishnamurthy, L; Rath, G K; Arya, L S; Pati, H; Saraya, A K
    Introduction of CNS chemoprophylaxis was a major milestone in the development of current therapy for acute lymphocytic leukemia. However, controversies are still existing for ideal form of CNS chemoprophylaxis. The present study was conducted to determine the efficacy of intrathecal methotrexate (IT-MTX) with and without cranial radiotherapy in preventing CNS relapses in Indian children. CNS chemoprophylaxis comprising of six injections of intrathecal methotrexate (12 mg/M2) was administered alone or along with cranial radiotherapy (2000 GY) in 76 children each after successful induction remission. Cranial radiotherapy (RT) with intrathecal methotrexate (IT-MTX) was observed to be more effective as CNS relapses were seen in 11.8% of children as compared to 16.8% of children receiving IT-MTX alone. IT-MTX along with cranial RT delayed the occurrence of CNS relapses and prolonged the event free survival periods.
  • Thumbnail Image
    Item
    Evaluation of utility of immunohistochemistry markers as a tool for objective diagnosis of low-grade myelodysplastic syndrome in routine reporting: Prospective observational study
    (Wolters Kluwer - Medknow, 2022-12) Juneja, R; Pati, H; Dange, P; Gupta, G; Mahapatra, M; Tyagi, S; Saxena, R.
    Purpose: Diagnosis of myelodysplastic syndrome (MDS) primarily relies on the detection of morphological dysplasia in bone marrow. It is subjective and many studies have reported lack of interobserver agreement in reporting. Biopsy is preferred specimen for megakaryocyte assessment. We studied 43 bone marrow biopsies from 40 suspected MDS patient having persistent undiagnosed cytopenia. Utility of immunohistochemistry (IHC) with CD61 and p53 in detecting low-grade MDS was analyzed over routine morphology. Method and Results: Total number of megakaryocytes and number of dysplastic megakaryocytes seen on CD61 IHC was significantly higher than that on H and E stain (P value < 0.05) Out of total 43 biopsies, 13 [30.2%] cases showed dysplastic megakaryocytes that were confirmed by interobserver agreement after IHC. From 30 cases with no significant dysplasia on morphology, 21/43 [48.8%] cases showed >10% dysplastic megakaryocytes on CD61 (P value 0.0001). Nine cases showed no significant dysmegakaryopoiesis with either H and E or CD61 IHC. Fourteen cases could meet higher cut off (30%) of dysmegakaryopoiesis with CD 61 IHC. Out of total 34 cases showing significant dysplasia 7 cases (20.6%) showed positivity for p53 on IHC, which is little less than that reported in low-grade MDS. Conclusion: CD61 IHC is helpful in making correct diagnosis of MDS in cases with minimal dysplasia and should be performed before excluding possibility of MDS on morphology in a patient with undiagnosed cytopenia. IHC is cost effective tool for MDS diagnosis in developing world where access to extensive flow cytometery and molecular testing is limited.
  • Thumbnail Image
    Item
    Expect the unexpected – Loss of surface CD3 on flow cytometry in hepatosplenic T-cell lymphoma: An eye opener
    (Indian Association of Pathologists and Microbiologists, 2018-06) Chauhan, R; Tyagi, S; Mirgh, S; Mishra, P; Seth, T; Mahapatra, M; Pati, H; Saxena, R
    Hepatosplenic T-cell lymphoma (HSTCL) is a rare extranodal T-cell lymphoma that shows preferential sinusoidal infiltration of spleen and liver. It usually shows bright expression of surface CD3 (sCD3) with restriction for γδ-T cell receptors (TCR). We present a case of a 34-year-old male who presented with hepatosplenomegaly and B symptoms. His peripheral blood and bone marrow (BM) was involved by atypical lymphoid cells that were CD2+, CD7+, CD56+, cytoplasmic CD3+, and sCD3− on immunophenotyping by flow cytometry. As sCD3 is a lineage marker for T-cell lymphomas, the loss of sCD3 posed a diagnostic dilemma. However, typical pattern of sinusoidal BM and liver involvement by CD3+ cells and TCR gene rearrangement positivity led to final diagnosis of HSTCL. The differential diagnosis, workup, and clinical course of the case are discussed. To the best of our knowledge, only one case of de novo HSTCL with negative sCD3 has been reported before in the literature.
  • No Thumbnail Available
    Item
    Hairy cell leukaemia with possible pulmonary and renal involvement.
    (1986-10-01) Sharma, S K; Wali, J P; Pati, H; Pande, J N; Guleria, J S
  • No Thumbnail Available
    Item
    Hemoglobin A2 in iron deficiency and megaloblastic anemia: relation with severity and etiology of anemia.
    (1987-04-01) Rai, R; Pati, H; Sehgal, A K; Sundaram, K R; Saraya, A K
  • No Thumbnail Available
    Item
    Hypoplastic anemia: a preleukemic state in acute lymphocytic leukemia.
    (1991-10-01) Desai, N; Vohra, P; Pati, H; Choudhry, V P
  • No Thumbnail Available
    Item
    Morphologic & cytochemical correlation in adult & childhood acute leukemia.
    (1984-03-01) Pati, H; Seth, P; Kumar, R; Choudhry, V P; Bhargava, M; Saraya, A K
  • Thumbnail Image
    Item
    A Peripheral Smear Finding Beyond Cells: Cryoglobulins in a Case of Lymphoplasmacytic Lymphoma
    (Dr. J.S. Sodhi Memorial Educational Society, 2019-07) Karthika, KV; Tripathi, P; Pati, H; Saxena, R
    A well prepared peripheral smear is an indispensable requisite for the diagnosis of hematological disorders and in some situations, non-hematological diseases. Here, we present the typical hemogram and peripheral smear findings of circulating cryoglobulins that led to the unraveling of the underlying lymphoproliferative disorder. A 51-year lady presented with symptoms of anemia since four months. Her hemogram showed anemia and leucopenia with flagging of platelet count. Peripheral smear at room temperature revealed marked artefactual changes in red blood cells including fragmentation. The morphology was better appreciated after incubating the sample at 37°C and showed normocytic normochromic RBCs, thrombocytopenia with a few lymphoplasmacytic cells and amorphous pinkish material in the background. Bone marrow examination showed near total replacement of marrow spaces by lymphoid cells positive for CD20 and CD138 and was diagnosed as lymphoplasmacytic lymphoma. Cryoglobulins can thus cause a range of laboratory artefacts which need to be recognized, warranting further search for possible underlying etiologies.
  • No Thumbnail Available
    Item
    Platelet aggregation in homozygous beta thalassaemia.
    (1987-07-01) Rai, R; Pati, H; Arya, L S; Saraya, A K
  • No Thumbnail Available
    Item
    Platelet function disorders in north India.
    (1994-01-01) Saraya, A K; Saxena, R; Dhot, P S; Choudhry, V P; Pati, H
    BACKGROUND. Platelet function disorders are a fairly common cause of bleeding manifestations. Although their relative types and incidence are well documented, data from India are lacking. METHODS. Between 1970 and 1991, we studied the clinical and laboratory features of 144 north Indian patients who presented to our hospital with a bleeding diathesis in whom coagulation disorders, von Willebrand's disease and a history of drug ingestion were absent. RESULTS. Isolated platelet factor 3 availability defect was the commonest (56 cases) followed by the thrombasthenias (49 cases), arachidonic acid pathway defect (26 cases), storage pool disease (8 cases) and the Bernard-Soulier syndrome (3 cases). Isolated platelet factor 3 deficiency was rare (2 cases). Two varieties of thrombasthenia were seen--the classical Glanzmann's (13 cases) and thrombopathic (36 cases). The latter was characterized by absent or sub-normal platelet aggregation with agonists along with a reduced (to less than 50% of normal) total platelet factor 3 content. This has not been reported from western countries. Patients with classical Glanzmann's thrombopathic thrombasthenia with absent platelet aggregation and isolated platelet factor 3 deficiency were severe bleeders. Their family history suggested an autosomal recessive transmission in Glanzmann's and thrombopathic thrombasthenia and a possible autosomal dominant transmission in isolated platelet factor 3 availability defect and isolated platelet factor 3 deficiency. CONCLUSION. The frequency of various types of platelet function disorders in Indians is similar to that in western populations except that the incidence of thrombopathic thrombasthenias is higher in India.
  • No Thumbnail Available
    Item
    Platelet storage pool disease.
    (1986-12-01) Pati, H; Saraya, A K
  • No Thumbnail Available
    Item
    Priapism in chronic myelogenous leukemia.
    (1992-01-01) Bhatia, P; Arya, L S; Chinnappan, D; Choudhry, V P; Pati, H