Browsing by Author "Pathak, A K"
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Item Acute dapsone poisoning in a child.(1967-10-01) Saxena, K M; Pathak, A KItem Acute extrapyramidal reaction to trifluoperazine dihydrochloride.(1969-10-01) Bajpai, P C; Pathak, A K; Sethi, V K; Bhargava, K PItem Effect of change in symptoms, respiratory status, nutritional profile and quality of life on response to treatment for advanced non-small cell lung cancer.(2008-10-05) Mohan, Anant; Singh, P; Kumar, S; Mohan, C; Pathak, A K; Pandey, R M; Guleria, RINTRODUCTION: Quality of life (QOL), and pulmonary and nutritional parameters are important outcome measures during treatment of lung cancer; however, the effect of chemotherapy on these factors and their relationship with clinical response is unclear. METHODS: Patients with non-small cell lung cancer (NSCLC) were evaluated for symptom profile, nutritional status (using anthropometry), pulmonary functions by spirometry and six minute walk distance (6 MWD), and QOL using the WHO-QOL Bref 26 questionnaire, before and after chemotherapy. RESULTS: Forty-four patients were studied (mean (SD) age, 55 (10) years, 75% males). The majority (98%) had stage III or IV disease and 72% were current / ex-smokers with median pack-years of 27.0 (range, 0.5-90). Some 61% had a Karnofsky Performance Scale (KPS) 70 or 80. The commonest symptoms were coughing, dyspnea, chest pain, anorexia and fever (79%, 72%, 68%, 57% and 40%, respectively). The mean (SD) 6 MWD was 322.5 (132.6) meters. The mean (SD) percentage forced vital capacity (FVC %), and forced expiratory volume in one second (FEV1 %) were 64.7 (18.8) and 57.8 (19.4), respectively. The mean (SD) QOL scores for the physical, psychological, social, and environmental domains were 52.9 (20.5), 56.1 (17.9), 64.5 (21.8), 57.1 (16.6), respectively. Fourteen patients (32%) responded to chemotherapy. Non-responders had significantly higher baseline occurrence of fever, anorexia, and weight loss, higher pack-years of smoking and poorer KPS compared to responders. Overall, chemotherapy caused significant decline in the frequency of coughing, dyspnea, chest pain, fever, anorexia, weight loss, and improvement in hemoglobin and albumin levels. There was no significant improvement in pulmonary functions, nutritional status, or QOL scores after treatment. CONCLUSIONS: Lung cancer patients have a poor QOL. Although chemotherapy provides significant symptomatic benefit, this does not translate into similar benefit in respiratory and nutritional status or QOL. Patients with constitutional symptoms, higher smoking burden, and poor KPS are less likely to respond to chemotherapy. Management of NSCLC must include strategies to improve various aspects of QOL, nutritional status and pulmonary reserve to achieve comprehensive benefit.Item Non small cell lung cancer (NSCLC): current status and future prospects.(2004-07-24) Pathak, A K; Bhutani, M; Mohan, A; Guleria, R; Bal, S; Kochupillai, VThe incidence of lung cancer is rising dramatically and it is now the commonest cause of mortality and morbidity not only in the industrialised countries, but in developing nations like India as well. Tobacco smoking has consistently been demonstrated to be an important aetiological factor, though lung cancer occurs in non-smokers also. In spite of great advances in radiological and molecular diagnostic techniques, the ideal screening marker for early detection of lung cancer has still not been found. Histological diagnosis and staging is essential for selecting the mode of therapy in patients with lung cancer. Stages I and II are amenable to surgery. However, advanced stage III and IV need an individualised combination of surgery, chemotherapy and radiotherapy. With a better understanding of the cellular mechanisms operating in carcinogenesis, newer target specific modalities are being developed and tested in order to stem this disease, which threatens to assume epidemic proportions.Item Phenothiazine toxicity in paediatric practice with three case reports.(1969-07-01) Bajpai, P C; Sethi, V K; Pathak, A K; Tripathi, T KItem Role of forensic medicine in administration of justice a critical review.(2011-04) Sinha, U S; Yadav, Mukesh; Uttam, Soni; Pathak, A K; Singh, SanjuTwo small round opaque shadows of metallic densities opined as that the injury was not a firearm injury but was self inflicted one by the first Medical Board under the Chairmanship of Chief Medical Officer. Opinion of another Medical Board comprising Forensic Medicine expert considered it as a: Clear cut case of firearm wound. Based on two contradictory opinions, Allahabad Court held that the Charge: sheet submitted under sections 323, 504, and 506 IPC, ought to have been submitted under some graver sections too. This paper deals with a critical review of case where two Medical Boards were constituted in the interest of justice. Views of various other relevant judgments of Hon’ble Supreme Court and various High Courts emphasizes the importance of Forensic Medicine in the administration of justice and need for refresher courses and training for medical officers suggested to avoid future recurrences of such nature are discussed in brief.Item Standardization of Ethanolic Extract of Cucurbita Maxima Seed.(2012-08) Bajpai, Richa; Jain, Nidhi; Pathak, A KStandardization is an important step for the establishment of a consistent biological activity, a consistent chemical profile, or simply a quality assurance program for production and manufacturing of herbal drugs preparation of any herbal formulation identification, evaluation and standardization is rudimentary identification involves the morphology, microscopy parameter of plants, evaluation and standardization of herbal drugs includes physical, chemical and biological parameters. These parameters are crucial for preparation of accurate and potent formulation. The present communication attempts to investigate pharmacognostical and phytochemical details of Cucurbita maxima, (Cucurbitaceae). The Preliminary phytochemical analysis revealed presence of carbohydrates, alkaloids, flavonoids, saponins, proteins and amino acids in alcoholic extract. HPTLC studies reveal that alcoholic extract gives 3 spots and alcoholic extract depicts 5 spots on the TLC plate in Butanol: acetic: water solvent system with Ninhydrin as spraying agent and 3 spots with vanillin as spraying agent and with butanol: phenol: water (6:1:1) 4 spots were seen with Ninhydrin as spraying agent and 2 spots were seen with vanillin as spraying agents. The GC/MS of pet ether methyl ester showed number of peaks. Out of which 3 highest peaks in descending order were taken into consideration. OSAZONE were formed which showed needle shaped crystals of glucaosazone. The study revealed specific identities for which may play a key role in identification of plant and can be useful in standardization of the herbal drugs.Item Sterotonin metabolism in kwashiorkor.(1968-06-01) Sharma, N L; Pathak, A K; Bhargava, K PItem Survival in small cell lung cancer in India: prognostic utility of clinical features, laboratory parameters and response to treatment.(2006-04-23) Mohan, A; Goyal, A; Singh, P; Singh, S; Pathak, A K; Bhutani, M; Pandey, R M; Guleria, RBACKGROUND: Predictors of survival and response to treatment in patients with small cell lung cancer (SCLC) are ill-defined and unclear. In an attempt to assess the impact of common presenting symptoms and laboratory values on survival, we undertook this retrospective review of patients with SCLC. To our knowledge, there is no study on survival in SCLC patients from the Indian subcontinent. DESIGN: Retrospective Cohort study. MATERIALS AND METHODS: All newly diagnosed small cell lung cancer cases from December 2001 through December 2004, were identified and clinical data on presenting symptoms and laboratory findings from their hospital records, noted. The influence of various pretreatment factors on survival was investigated using Kaplan-Meier plots and Cox multivariate regression model. RESULTS: 76 subjects were included (84% males, 91% smokers). 57% patients had five or more symptoms at presentation. Cumulative symptom burden was strongly associated with survival (P =0.02). Survival was also significantly related with Karnofsky performance status (KPS) (P =0.04), disease extent (P =0.03) and symptomatic response to treatment (P< 0.001). Patients with higher hemoglobin (P =0.02), serum sodium (P =0.04) and serum globulin (P =0.02), survived significantly longer. By multivariate regression analysis, hemoglobin, KPS and brain metastases, were significant predictors of survival (P =0.01, P =0.02, P< 0.01 respectively). CONCLUSION: Cumulative symptom burden, KPS, disease extent and symptomatic assessment of improvement after treatment, are useful predictors of survival. This has important clinical implications, keeping in view, the infrastructure and cost involved in more objective tests like CT scan, for evaluation of disease extent and prognosis. These findings can provide a simple basis for predicting prognosis in small cell lung cancer, especially in developing countries like ours.Item Syndrome of retarded growth, obesity, muscular hypotonia and mental deficiency (Prader-Willi syndrome). Report of a case.(1968-09-01) Pathak, A K; Sharma, N LItem Turner's syndrome in a male child. Report of a case.(1968-11-01) Pathak, A K; Sharma, N L