Browsing by Author "Patel, M."
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Item Analyzing the medical use of cannabis for cancer patients: a critical perspective(Medip Academy, 2024-03) Patel, R.; Patel, M.; Patel, Z.; Kavani, H.; Patel, D.; Shaikh, S.The utilization of cannabis in oncology presents a multifaceted approach to addressing the complex challenges associated with cancer treatment. With roots tracing back to ancient medicinal practices, cannabis contains numerous compounds, including cannabinoids like tetrahydrocannabinol (THC) and cannabidiol (CBD), that interact with the body's endocannabinoid system. These interactions offer potential therapeutic benefits, ranging from antiemetic and analgesic effects to the inhibition of cancer growth processes. While clinical evidence supports the efficacy of cannabinoids in managing symptoms and enhancing the quality of life for cancer patients, caution is warranted due to potential interactions with conventional medications. Understanding the mechanisms of action, optimal administration routes, and potential side effects is crucial for integrating cannabis into personalized cancer care plans. By navigating these considerations thoughtfully, medical practitioners can harness the therapeutic potential of cannabis to complement traditional cancer treatments and improve patient outcomes in the field of oncology.Item Bilateral Narrow Internal Auditory Canal With Duplication: High Resolution CT And MRI Findings(Association of Health Professionals and Health Educators, 2021-03) Patel, N; Jain, N; Raiyani, H; Patel, M.Inner ear malformations account for only 20 % of cases of congenital sensorineural hearing loss.A narrow internal auditory canal (IAC) with duplication is a very rare congenital anomaly that can be associated with other malformative ear abnormalities. Identification and characterization of these abnormalities will be crucial for the proper management of patients.We report two cases of bilateral duplicated internal auditory canal with other associated inner ear anomalies.Item Design And Development Of Rilpivirine Nanoparticle Containing Chitosan Using Ionic Gelation Method For Hiv Infections(Innovare Academic Sciences Pvt. Ltd., 2020-02) Patel, M.; Patel, N. V.; Patel, T. B.Objective: The primary objective of the current research was to prepare rilpivirine loaded Nanoparticles containing Chitosan using the ionic gelation method for HIV infections. Methods: The nanoparticles of rilpivirine were prepared using the ionic gelation technique. Further, nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), scanning electron microscopy (SEM) and in vitro drug release. Results: The optimized nanoparticles were found with a particle size of 130.30±5.29 nm (mean±SD) and entrapment efficiency (% EE) of 77.10±0.50%. Scanning electron microscopy technique exposed spherical particles with uniform size. It was observed that the nanoparticles created showed the absence of the crystalline nature of the drug and its switch to the amorphous state. Results showed that more than 45% of the pure drug is released in 50 min and after 90 min almost about 95% of the drug is released. Conclusion: The research study concluded that the in vitro release profile of nanoparticles was found to be sustained up to 24 hr. Sustained release of the rilpivirine could improve patient obedience to drug regimens, growing action effectiveness.Item Evaluation of obstetric and perinatal outcome of pregnancy with bad obstetric history(Mrs Dipika Charan of MedScience (India) Publications, 2023-06) Shukla, H; Dalal, R; Patel, M.Background: Adverse perinatal outcome has always been a devastating experience for the mother. Advanced maternal age and other risk factors are independent risk factor for perinatal outcome. Therefore, aim of study is to compare the effect of these factor in different study group. Aims and Objectives: Case–control study has been conducted to evaluate obstetrics outcome, maternal morbidity, and perinatal outcome in patients with bad obstetric history. Materials and Methods: A prospective observational case–control study has been conducted in two groups; GROUP A: BOH group (n = 44) and GROUP B: Controls (n = 88) who fulfilled inclusion criteria in Department of Obstetrics and Gynaecology, GMERS Medical college, Sola during the period of August 2018 to August 2020. Statistical analysis was done by descriptive statistics and qualitative and quantitative method. Results: Incidence of hypertension in Group A was 25%, while in Group B incidence was 6.8%. Incidence of hypertension was 4.5 times higher in Group A than B which was statistically significant (P < 0.05). Incidence of PROM, gestational diabetes mellitus, thyroid dysfunction was higher in Group A than Group B. Higher incidence of preterm delivery found in Group A than in Group B which was statistically significant (P < 0.05). Conclusion: Among all BOH group, cases with previous history of preterm delivery, still birth, recognition of prior learning, and HTD were the major risk factors which could be responsible for adverse obstetric and perinatal outcome.Item Similar prevalence of anxiety and depression symptoms in any ICU survivor patient relative(Medip Academy, 2023-11) Shah, A.; Shah, A.; Rathod, D.; Patel, M.; Hansora, S.Background: Iwashyna et al defined a chronic critically ill (CCI) patient as any patient requiring care in ICU for more than or equal to 10 days. Physicians often assume that the prevalence of anxiety and depression symptoms in relatives of CCI patients would be higher than in those patients who are not CCI. We hypothesized that there would be no difference in the prevalence of anxiety and depression symptoms of relatives of a CCI and those whose patients are not CCI. We aimed to establish that the prevalence of anxiety and depression symptoms are similar in relatives of any ICU survivor patient. Methods: The study was a non-interventional, observational, cross-sectional study. Relatives were evaluated as early as possible after day ten following ICU admission for CCI patients and non-CCI patients on or a day before discharge from ICU. During this evaluation, anonymous demographic data of relatives were captured, and PHQ-9 and GAD-7 scales were administered and completed by the relative. Results: A total of 418 relatives consented and were included in the study [104 in CCI patient group and 314 in non-CCI group]. Overall, the prevalence of anxiety and depression symptoms in the entire study cohort was 23.2% (95% CI, 19.4-27.5) and 16.5% (95% CI, 13.2-20.4), respectively. There was no statistical difference between the two groups in the proportion of PHQ-9 total score >9 (p value: 0.577) as well as the GAD-7 total score (p value: 0.816). Conclusions: There was no difference in the prevalence of anxiety and depression symptoms in relatives of a CCI versus those whose patients are not CCI.Item Survey-based study evaluating current interventions to improve medication adherence(Mrs Dipika Charan of MedScience (India) Publications, 2023-06) Nagrani, V; Shah, NA; Patel, M.Background: Non-adherence to prescribed medication regimens is an increasingly growing problem, with rates ranging from 40% to 94%. Medication non-adherence leads to increase in morbidity and mortality as well as an increase in healthcare costs. There is a need to improve medication adherence through various interventions that are both implementable and feasible for clinicians. For this purpose, it is essential to understand the perceptions of clinicians regarding the frequency and effectiveness of current practices. Hence, this study is conducted with the core aim of identifying current interventions in use to improve medication adherence as well as perceived effectiveness. In addition, we aim to identify the potential barriers to improving medication adherence. Aims and Objectives: (1) To identify commonly used intervention strategies to improve medication adherence and (2) to assess potential effectiveness of these strategies. Materials and Methods: A questionnaire was administered to 100 clinicians at a tertiary care teaching hospital. Twenty questions about interventions to improve medication adherence and twenty-three questions about barriers to improving medication adherence were included in the questionnaire. Likert scales were used to measure the frequency and effectiveness of interventions. Results: Clinicians (64%) were most commonly identified as currently responsible to conduct interventions. Intervention practices were rated at about 4.71 on a scale of 1 to 10. Strategy most commonly in use all the time included direct education to the patient (69%), whereas electronic reminders (57%) and electronic monitoring (63%) were most commonly identified as not at all in use. Strategies most commonly considered as largely effective included giving written treatment plans to the patient. Most common identified barriers included socioeconomic status of patients (57%) and cost of therapy (57%). Conclusion: The identification of commonly used interventions to improve medication adherence and their perceived effectiveness helps health-care practitioners design better strategies to address non adherence.