Browsing by Author "Patcharin Homchaem"

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    Association between p53 codon 72 and GSTM1 polymorphisms and risk of hepatocellular carcinoma
    (Thai Cancer Journal, 2010-04-07) Danai Tiwawech; Wutthi Sumetchotimaytha; Aree Prastthipayong; Yaninee Jarratwisarutporn; Patcharin Homchaem; Takafumi Ishida
    Hepatocellular carcinoma (HCC) is a serious public health problem that caused vastly losses in Thailand annually. Recently, P53 codon 72 and GSTM1 polymorphisms have been found to associate with several cancers. The aim of this study is to investigate the association between P53 codon 72 and GSTM1 polymorphisms and risk of HCC development in Thais. The frequencies of P53 codon 72 genotypes (Arg/Arg, Arg/Pro and Pro/Pro genotypes) and GSTM1 genotypes (GSTM1+) and (GSTM1-) from 200 cases of HCC as well as 400 age-matched healthy control were analyzed by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and PCR, respectively. In overall, the frequencies of P53 codon 72 polymorphism in HCC group were significantly different from those of healthy control. The Pro/Pro carriers had increased risk for HCC at 1.9-fold as compared to Arg/Arg carriers (OR=1.9; 95%CI=1.2-3.3). Similarly, the overall of frequencies of GSTM1 genotypes of GSTM1 polymorphism in HCC group were significantly different from those of healthy control. In addition, GSTM1- carriers had increased risk for HCC at 1.8-fold as compared to GSTM1+ carriers (OR=1.8; 95%CI=1.3-2.5). The results of this study suggest that P53 codon 72 and GSTM1 polymorphisms are associated with the increased risk of HCC and may be a useful tool for predicting and searching the high risk group of HCC in Thai population.