Browsing by Author "Pandey, Varsha"

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    Histopathological spectrum of round cell tumors in a tertiary care center of Chhattisgarh, India
    (Wolters Kluwer – Medknow, 2024-07) Siddiqui, Rabia Parveen; Pandey, Varsha; Ratre, Dakesh
    Background and Objectives: The term “round cell tumors” (RCTs) refers to a diverse group of neoplasms that share similar histopathological features, including uniform, small, round cells with round nuclei, fine chromatin, and scanty clear or eosinophilic cytoplasm. This study assesses the spectrum of RCTs across different age and sex groups. Materials and Methods: The study included all histologically diagnosed cases of RCT from the Department of Pathology over 5 years. Results: The results revealed that 107 RCT cases were diagnosed through histopathology and further analyzed using immunohistochemistry (IHC). The patients’ ages ranged from 1 to 75 years, with the highest incidence (34%) occurring in the 16–45 years age group. Of the 107 cases, 54 (51%) were males and 53 (49%) were females. Thirteen different types of RCTs were identified, with non-Hodgkin’s lymphoma being the most common (29.90%). Most cases (46%) were in the head and neck region. Interpretation and Conclusion: This study concludes that RCTs are widespread in their anatomical distribution and exhibit diverse patterns of round cells morphologically, making histopathological diagnosis challenging. IHC is highly valuable for diagnosis, though some cases require molecular diagnosis for confirmation.
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    The range of endometrial pathologies in patients with abnormal uterine bleeding at a tertiary care center in central India
    (Wolters Kluwer – Medknow, 2024-07) Siddiqui, Rabia Parveen; Pandey, Varsha; Chandrakar, Sonal; Bhaskar, Vanita
    Background: Endometrial disorders are among the most common gynecological conditions globally. Abnormal uterine bleeding (AUB) refers to any irregularity in the timing, volume, or pattern of menstrual blood flow. This study investigates the histopathological spectrum of endometrial changes across various age groups in patients presenting with AUB as their primary symptom. Materials and Methods: The study analyzed 226 endometrial biopsies/specimens collected over two years from patients with AUB as the main complaint. These specimens were processed, and slides stained with hematoxylin and eosin (H&E) were examined to determine the endometrial patterns. A chi-square test assessed the relationship between age and specific endometrial pathologies. Observations and Results: Most of the 226 cases were from perimenopausal women (40–49 years), representing 57% of the total, with proliferative endometrium being the most common pattern (40.9%). About 20% of the cases were in the reproductive age group (<40 years), where typical hyperplasia was the most prevalent pattern (45.7%). Additionally, 23% of the cases involved postmenopausal women (>49 years), with endometrioid carcinoma being the most frequent pattern observed. Other endometrial patterns included disordered proliferative endometrium, endometritis, endometrial polyps, Arias–Stella reaction, and progesterone effects. Conclusion: Patients with AUB present with a wide range of endometrial patterns, from normal cyclic endometrium to malignancies. Histopathological examination remains the gold standard for diagnosing AUB, showing a significant association between endometrial lesions and age.
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    A study of the histopathological spectrum of thyroid neoplasms in a tertiary health care center
    (Wolters Kluwer – Medknow, 2024-12) Siddiqui, Rabia Parveen; Bhaskar, Vanita; Swami, Kavita; Pandey, Varsha; Chandrakar, Anubhav; Mangrulkar, Kasturi
    Background: Thyroid gland lesions are common and can result from systemic conditions such as Graves’ disease or localized abnormalities like nodular enlargement or tumors. Thyroid malignancies are the most prevalent endocrine cancers, accounting for approximately 92% of all endocrine malignancies. This study aims to explore the spectrum of thyroid neoplasms in a tertiary healthcare center. Aims and Objectives: The primary objective of this study was to examine the histopathological spectrum of thyroid neoplasms in a tertiary healthcare center. Additionally, the study aims to assess the frequency of various thyroid neoplasms across different age groups and genders and to identify any associated nonneoplastic thyroid lesions that occur alongside thyroid neoplasms. Materials and Methods: This observational descriptive cross-sectional study was conducted in the Department of Pathology, Pt. Jawahar Lal Nehru Memorial Medical College, Raipur, Chhattisgarh, India, over 50 months from January 2020 to March 2024. A total of 71 cases meeting the inclusion criteria were analyzed. Results: Of the 71 thyroid specimens examined, 12 cases (16.9%) were benign, whereas 59 cases (83.09%) were malignant. The study demonstrated a significant female predominance with a female-to-male ratio of 9.1:1 (64 females and 7 males). Most cases were observed in the 21–30 years age group, with a mean age of 32.3 years. Papillary carcinoma was identified as the most common malignant lesion, accounting for 35 cases (52.1%), whereas follicular adenoma was the most common benign lesion, accounting for 9 cases (12.7%). Conclusion: Accurate diagnosis of thyroid malignancies requires a combination of clinical history, radiological imaging, thyroid function tests, and thorough histopathological examination. Early and proper diagnosis facilitates more effective treatment decisions, standardized management protocols, and improved patient outcomes.
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    A study on histomorphological analysis of gestational trophoblastic disease
    (Wolters Kluwer – Medknow, 2024-07) Neral, Arvind; Varma, Ruchi; Grihi, Priyanka; Mangrulkar, Kasturi; Pandey, Varsha; Bhaskar, Vanita
    Background: Gestational trophoblastic disease (GTD) represents a diverse group of conditions characterized by abnormal trophoblastic proliferation within the placenta. GTD includes benign and malignant lesions, ranging from complete and partial hydatidiform moles to more severe forms like invasive moles, choriocarcinoma, placental site trophoblastic tumors (PSTTs), and epithelioid trophoblastic tumors. Given that neoplastic GTD lesions respond remarkably well to chemotherapy, early and accurate histopathological diagnosis is crucial as it directly influences treatment and prognosis. Aim and Objectives: This study examined the histomorphological features of various types of GTD alongside key clinical factors such as age, parity, and gestational period. Materials and Methods: The study was conducted in the Department of Pathology over the course of10 years, from January 2014 to January 2024. All cases of GTD confirmed through histopathological examination of hematoxylin and eosin-stained slides were included in the analysis. Results: Out of 60 diagnosed cases of GTD, 34 (56.66%) were complete hydatidiform moles, 22 (36.67%) were partial hydatidiform moles, 1 (1.67%) was an invasive mole, 1 (1.67%) was choriocarcinoma, and 2 (3.33%) were PSTTs. The age of the affected patients ranged from 18 to 45 years, with the highest incidence observed in the 20–25 year age group (30 cases, 50%). Most cases (33, 55%) occurred during the first trimester, with a predominance among primigravida patients (28 cases, 46.66%). The most common clinical presentation was per vaginal bleeding, reported in 56 cases (93.33%). Conclusion: Although GTD can lead to serious complications, including metastasis, it is treatable. In this study, the complete hydatidiform mole was the most frequently encountered lesion and is associated with a higher risk of severe complications such as persistent GTD, invasive moles, and choriocarcinoma. Thus, early and accurate histopathological diagnosis is vital for the timely initiation of therapy, ultimately reducing the mortality rate. This study highlights the various categories and histomorphological features of GTD, emphasizing the importance of understanding its clinical presentation to mitigate disease burden and complications.