Browsing by Author "Pal, AK"
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Item Association of serum uric acid with waist-hip ratio: A promising index for assessing cardiovascular disease risk profile(Mrs Dipika Charan of MedScience (India) Publications, 2022-05) Chaturvedi, A; Pal, AK; Singhal, K; Verma, N.Background: Abdominal obesity is associated with insulin resistance, in turn, hyperinsulinemia and visceral adiposity lead to an increased uric acid (UA) absorption in renal tubules. Aim and Objectives: Accumulation of visceral fat is an underlying component of metabolic syndrome. Furthermore, the waist-hip ratio is an indirect tool for assessing visceral fat. The present study evaluates the association of UA levels with the waist-hip ratio. Materials and Methods: 160 subjects aged 18–60 years were enrolled in the study (those having any anatomical deformity, diabetes, and/or hypertension for more than 5 years were excluded from the study). Their anthropometric parameters, blood pressure, lipid profile, fasting plasma glucose, and serum UA levels were measured. Results: The study population was divided into three groups based on UA levels. The waist-hip ratio in a group of the hyperuricemic population was more as compared to groups of normal and below normal UA levels population and the association of UA level with waist-hip ratio was found to be significant (P = 0.045). Conclusion: The over-inflow of free fatty acid to the liver from accumulated visceral fat may be linked to the de novo purine synthesis through the pentose phosphate pathway, which may accelerate the production of UA.Item Effect of endurance training on sympathetic reactivity by sustained hand grip test(Mrs Dipika Charan of MedScience (India) Publications, 2022-11) Iqbal, TM; Singhal, K; Pal, AK; Karim, SM.Background: The endurance training plays a key role in maintaining not only the physical fitness but also overall wellness of an individual. It boosts up the immune system and cardiovascular endurance. The training responses were found to be better in hypertensive patients as compared to normotensives. Aims and Objectives: The aims of this study were to evaluate the effect of endurance training on blood pressure (BP) response to sustained hand grip in the study group and control group before and after 3 months of training. Materials and Methods: Sixty apparently healthy young subjects divided into two groups: Exercise group (30 subjects) control group (30 subjects). Exercise group performed endurance training by running on treadmill alternately for 3 months, while control group did nothing. Tests were carried out with the help of CANWin machine which uses Tacho Cardio Gramme response to sustained hand grip for assessment of sympathetic function reactivity. For the test, subjects were asked to maintain the pressure on dynamometer for 5 min at 30% of maximum voluntary contraction. The BP was recorded at first before start of isometric contraction and at 5 min after the onset of isometric contraction. Results: No statistically significant difference was found in the mean systolic BP (SBP) and mean diastolic BP (DBP) between the exercise and the control group before exercise and after 5 min during exercise. Statistically significant difference was found in the mean change in DBP, but no significant mean change in SBP was found between exercise and control group before exercise and 5 min after (during exercise) after completing endurance training. A significant difference was observed among the exercise group in the change in SBP at 5 min after hand grip during exercise. Conclusion: Parasympathetic functions show favorable changes with aerobic exercise, while sympathetic system does not show such responses.