Browsing by Author "O'Holohan, D R"
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Item Clinical trial of phenyelene di-iso-thiocyanate (1.4), Jonit, in the treatment of hookworm disease in Malaysia.(1971-03-01) O'Holohan, D R; Hugoe-Matthews, J; Kanagasabai, KItem Increased frequency of chloroquine resistant P. falciparum on a rubber estate in Peninsular Malaysia during two years of systematic chloroquine treatment.(1975-12-01) Dondero, T J; Parsons, R E; O'Holohan, D RChloroquine pressure was applied over a 22 month period on a somewhat isolated, malarious rubber estate by examination of residents at 4-week intervals and treatment of parasitaemias with chloroquine. During this time the monthly attack rate for P. falciparum rose four-fold to an average of nearly 18% per month, while that of P. vivax remained relatively constant at about 8%. Eight in vivo chloroquine resistance studies, which allowed both detection of late recrudescing R-I resistance and estimation of the risk of reinfection, showed an apparent rise in the drug resistance rate, from 12% to 20% prior to the study to the range of 40-50%. Virtually all resistance encountered was R-I in nature. There was no convincing evidence of chloroquine resistance among 148 tested P. vivax infections.Item Malaria suppression and prophylaxis on a Malaysian rubber estate: sulformethoxine-pyrimethamine single monthly dose vs chloroquine single weekly dose.(1971-06-01) O'Holohan, D R; Hugoe-Matthews, JItem Single dose regimens of phenylene di-iso-thiocyanate (1,4) Jonit, in the treatment of hookworm infestation in Malaysia.(1972-09-01) O'Holohan, D R; Hugoe-Matthews, J