Browsing by Author "Nu Nu Lwin"

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    Geographical variation of the biological properties of Russell's viper venom: A Prelliminary report
    (1993-08-01) Tun Pe; Nu Nu Lwin; Aye Aye Myint; Kyi May Htwe; Khin Aung Cho
    Venoms from 4 localities (Daik-U,Kungyankone, Htantabin and Htaukkyant) were studied by SDS-PAGE electrophoresis. Biological properties of venom such as lethality, haemorrhagic, necrotic, coagulant, defibrinogenating capillary permeability increasing and phospholipase activities were carried out according to WHO recommended techniques and standard methods. Venom from Daik-U locality was most lethal, haemorrhagic and necrotic compared to others. It possessed potent defibrinogenating, capillary permeability increasing and phospholipase (indirect haemolysis) activities as well. Kungyankone venom possessed potent coagulant and phospholipase activities with poor defibrinogenating and lethality. Htaukkyant and Htantabin venoms have similar biological properties except the former has poor phospholipase activity. SDS-PAGE electrophoresis and transblotting experiment of venoms showed quantitative difference in numbers of protein band among them. Geographicasl variation of venom may be responsible for the discrepancy in clinical features observed following Russell's viper bites in different localities.