Browsing by Author "Nayak, Manas Kumar"

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    Blood culture positive sepsis and sensitivity pattern in a tertiary care neonatal centre in eastern India
    (Medip Academy, 2019-03) Rath, Soumini; Panda, Santosh Kumar; Nayak, Manas Kumar; Pradhan, Deepti Damayanty
    Background: The objective of this study is to evaluate sensitive pattern of causative organisms of neonatal sepsis with its clinical outcome in a tertiary neonatal care unit of eastern India.Methods: This retrospective observational cohort study was done in a tertiary care hospital of Odisha. All the blood culture positive neonatal sepsis cases, excluding neonates with multiple congenital malformations, diagnosed during January 2017 to December 2018 were analysed using descriptive summary statistics.Results: A total of 73 neonatal sepsis cases were diagnosed by BacT/Alert and VITEK-2 blood culture method. Among them, 50 (68%) babies had gram negative sepsis,14 (19%) cases of gram-positive sepsis and nine (13%) cases of fungal sepsis. In present study 38 (52%) cases were early onset sepsis, 38(52 %) babies were term, 55(75%) were male and 44 (60%) babies were out born. Klebsiella pneumonia and Acinetobacter were the most common organism in early onset and late onset sepsis respectively. Among gram negative organism (GNB), 66% were multi drug resistant. A fifty percent of gram-negative organism were sensitive to meropenem and 28% were sensitive to piperacillin/tazobactam. The sensitivity of GNB to colistin, ciprofloxacin, amikacin was 76%, 64% and 56% respectively. The sensitivity of gram-positive organisms to linezolid, vancomycin, teicoplanin and penicillin were 92%, 85%,85% and 20% respectively. Survival rate among culture positive sepsis was 83%.Conclusions: Multi drug organisms are emerging in modern neonatal care practice. Practice of antibiotic stewardship may save the babies from multidrug resistance organism in future.
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    The comprehensive computational study on PE11 gene of Mycobacterium tuberculosis involved in virulence
    (CSIR-National Institute of Science Communication and Policy Research (NIScPR), 2024-02) Nayak, Manas Kumar; Singh, Neha; Dhull, Kanika Singh; Parida, Preetinanda; Mohakud, Nirmal Kumar
    Since its initial discovery more than a decade ago, Mycobacterium tuberculosis has been the subject of significant scientific intrigue. The PE11 gene plays a pivotal role in mediating host-pathogen interactions within Mtb. Despite the fact that a comprehensive understanding of PE11 activities has yet to be achieved, evidence suggests that PE11 proteins play a role at various levels of the infectious process. According to several publications, PE11 (lipX) proteins, unique to pathogenic mycobacteria, are overexpressed during macrophage infection and inactive in TB patients. In this work, bioinformatics analysis was employed to anticipate the involvement of PE11 in mycobacterial virulence. The physicochemical characteristics, conserved domains, and theme of the obtained sequences were utilized to describe them structurally and functionally. Furthermore, homology modeling assisted in determining the 3-D structure and underlying residues in the active site area that interact with mshB and PPE41. Additionally, we reported on further research that may contribute to a more thorough understanding of the PE11 protein and its role in host-pathogen interactions. The findings presented here can be expanded upon and empirically confirmed.
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    Study of social and demographic determinants of severe acute malnutrition in children aged 6-59 months in a tertiary care centre of Odisha, India
    (Medip Academy, 2019-01) Jena, Pravati; Rath, Soumini; Nayak, Manas Kumar; Satapathy, Diptirekha
    Background: The objective is to study the various social and demographic determinants of severe acute malnutrition in children aged 6 months to 59 months in a tertiary care centre of Odisha, India.Methods: This is a hospital based prospective observational study done in a tertiary care centre of Odisha during the period of Nov 2015 to Oct 2017 in which all children with severe acute malnutrition as per WHO criteria in the age group 6 months to 59 months were enrolled and their socioeconomic and demographic details were evaluated.Results: Present study revealed a prevalence of severe acute malnutrition as 2.8%. Males (54.2%) were more affected than females (45.8%). Most common age group affected was 6-12 months (37.4%). Most of the children were from low socioeconomic status (96.4%) and from rural areas (84.8%).63.7% of the study population were unimmunised. Only 12.6% of the participants were exclusively' breast fed.100% of the children in the study population received top feeding with cow's milk.Conclusions: The prevalence of malnutrition is high in Odisha but most of the causative factors are preventable. Adequate education regarding exclusive breastfeeding, complementary feeding, immunisation, promotion of proper referral and health care services can help to improve nutritional status in the state of Odisha.