Browsing by Author "Murakami, Masanori"

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    Calcium Polycarbophil in the Management of Fecal Incontinence.
    (2016) Abe, Tatsuya; Kunimoto, Masao; Hachiro, Yoshikazu; Ebisawa, Yoshiaki; Hishiyama, Houhei; Murakami, Masanori
    Background: Few clinical studies have assessed the efficacy of calcium polycarbophil that is currently recommended as an ideal and initial bulk-forming agent in patients with fecal incontinence. Aims: The aim of this study was to evaluate the short-term outcomes of calcium polycarbophil administration to patients with fecal incontinence due to a range of etiologies. Study Design: This was a retrospective review of a single-institution experience. Methodology: In total, 223 patients treated with calcium polycarbophil were enrolled. Efficacy measures included changes in the Cleveland Clinic Incontinence Score and the Bristol Stool Form Scale. Results: Of the 223 patients who were enrolled, 195 were available for final analysis. Among the 195 patients, 15 (7.7%) experienced side effects; the most common side effects were constipation and hard stools. One month after the start of treatment, the mean Cleveland Clinic Incontinence Score decreased significantly compared with baseline (11.2±4.0 vs. 5.7±5.0, P = < .001). The mean stool consistency decreased significantly, with patients reporting more formed stools by the Bristol Stool Form Scale at 1 month than at baseline (4.4±1.5 vs. 3.9±1.1, P = < .001). Conclusions: Our findings suggest that monotherapy with calcium polycarbophil appears to be a safe and beneficial approach in the management of fecal incontinence.