Browsing by Author "Mukherjee, Sharmila B"
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Item The ABCD of Pediatric Practice.(2014-05) Mukherjee, Sharmila BItem Cryptococcal Meningoencephalitis – A Tale of 50 Years.(2015-06) Mukherjee, Sharmila BItem Developmental Pediatrician’s Viewpoint.(2015-09) Mukherjee, Sharmila BItem Diagnostic Accuracy of the Government of India Mother and Child Protection Card for Developmental Screening of Indian Children Aged 2-36 Months: A Hospital-based Mixed Method Study(Indian Academy of Pediatrics, 2023-03) Mukherjee, Sharmila B; Meghana, S; Singh, Arun Kumar; Sharma, Suvasini; Kapoor, DiptiBackground: Universal developmental screening is recommended at 9, 18, 24 and 36 months. The Government of India Mother and Child Protection (MCP) card is an immunization record that is used to monitor child development, and identify children requiring further evaluation. Objectives: To determine the diagnostic accuracy of the MCP card for developmental screening, and perform its item analysis. Study design: Mixed-method study (prospective study of diagnostic accuracy and qualitative study). Participants: Mother-child dyads of children between 2-36 months of age were recruited from the outpatient department or wards of a tertiary level children’s hospital from November, 2019 to October, 2021. Children with confirmed neurodevelopmental disorders/disability, and mothers with less than 6th standard education were excluded. Intervention: Each mother was given a MCP card, and taught how to mark the items. This was followed by the researcher’s evaluation (index tool). The reference tool was a comprehensive clinical assessment (CCA) by the researcher and an expert. The CCA included clinical examination of hearing, vision, and neurodevelopment; and psychometric assessment of development and adaptive function. Each mother underwent an in-depth interview. Overall and group wise psychometric properties of diagnostic accuracy were computed. The interview transcripts were analyzed thematically. Outcomes: The proportion of children with ‘fail’ and ‘delay’ by the evaluation of the researcher with the MCP card and the expert by the CCA, respectively. Results: The study population included 213 children (40.4% females). Fifty-two (24.4%) children were identified as ‘Fail’ by the MCP card and 43 (20.2%) as ‘delay’ by the expert’s CCA. The overall sensitivity and specificity was 83.7% (95% CI 69.3-93.2) and 90.6% (95% CI 85.2-94.5), respectively. Acceptable diagnostic accuracy was found in the age-group 7-9 months, 13-18 months, and 25-36 months. Conclusions: The MCP card may be used for developmental screening at 9, 18, and 36 months.Item Extra Hepatic Portal Vein Obstruction – Unobstructed(Indian Academy of Pediatrics, 2018-03) Elwadhi, Aman; Mukherjee, Sharmila BItem Global Developmental Delay and Intellectual Disability in Indian Children – Where do we Stand?(Indian Academy of Pediatrics, 2018-12) Kapoor, Dipti; Mukherjee, Sharmila BItem The Growing Menace of Dengue - Is Detection and Diagnosis Enough?(Indian Academy of Pediatrics, 2018-07) Chhapola, Viswas; Mukherjee, Sharmila BItem Growth, Nutritional status and Anemia in Indian Adolescents.(2016-10) Mukherjee, Sharmila BItem Hereditary Multiple Exostoses – A Tale of 50 years.(2015-09) Singh, Preeti; Mukherjee, Sharmila BItem Incorporating Developmental Screening and Surveillance of Young Children in Office Practice.(2014-08) Mukherjee, Sharmila B; Aneja, Satinder; Krishnamurthy, Vibha; Srinivasan, RoopaContext: Developmental concerns voiced by parents need to be responded to by structured developmental screening. Screening is the use of validated developmental screening tools to identify children with high risk of developmental delay out of an apparently normal population, while surveillance is the process of monitoring children identified as high risk by screening. Absence of routine screening can be attributed to problems at the level of parents, pediatricians or National policies. Hence vulnerable children are not detected early, and are denied benefit from appropriate developmental interventions. There are no definite guidelines for screening or for suitable tools for screening and surveillance. Objectives: To review existing developmental screening and monitoring tools for children validated in Indian under-five children, and provide a proposed practice paradigm for developmental screening in office practice. Evidence Acquisition: Scientific papers were retrieved by an electronic database search using MeSH terms ‘screening tool’, ‘developmental delay’, and filter of ‘children under 5 years’. Those relevant to office practice and validated internationally or in Indian children were reviewed. Results: Screening tools applicable to Indian office practice have been compared and certain tools have been recommended according to the level of risk of developmental delay. An algorithmic approach to screening has been given along with strategies for incorporation. Conclusions: Screening and surveillance for high risk of developmental delay are essential components of child health care. It is possible to incorporate both into routine practice.Item Infantile Tremor Syndrome – A Tale of 50 Years.(2015-07) Mukherjee, Sharmila BItem Leukemoid Reaction – A Tale of 50 Years.(2015-11) Mandal, Piali; Mukherjee, Sharmila BItem OMENS-plus syndrome.(2005-08-01) Kapoor, Seema; Mukherjee, Sharmila B; Paul, Ritu; Dhingra, BhavnaThe OMENS syndrome involves craniofacial maldevelopment of the orbit, ear cranial nerve and soft tissue, while OMENS-plus syndrome also includes extracraniofacial anomalies. These may be skeletal, cardiovascular, gastrointestinal, pulmonary, renal and central nervous system malformations. A fourteen-year-old girl presented with hemifacial microsomia, digital abnormalities and pancreatitis. She was diagnosed as O1M2E0N2S1--plus syndrome. Investigations revealed a type Ic choledochal cyst. The latter has not been reported as a gastrointestinal association earlier in literature to the best of the authors' knowledge.Item Pediatric Tuberculosis – What has Changed.(2016-06) Mukherjee, Sharmila B; Singhal, Kamal KItem Perinatal Mortality- What has Changed.(2016-03) Mukherjee, Sharmila B; Bandyopadhyay, TapasItem Psychopharmacology for Behavior Problems in Children(Indian Academy of Pediatrics, 2019-08) Mukherjee, Sharmila B; Kaushik, Jaya ShankarItem The Renal Cysts and Diabetes (RCAD) Syndrome in a Child with Deletion of the Hepatocyte Nuclear Factor-1β Gene.(2010-12) Aggarwal, Varun; Krishnamurthy, Sriram; Seth, Anju; Bingham, Coralie; Ellard, Sian; Mukherjee, Sharmila B; Aneja, SatinderThe authors describe a 14-yr-old boy who presented with non-ketotic hyperglycemia, elevated serum creatinine levels and deranged liver function. There was no microalbuminuria or proteinuria. He also had mild mental retardation with learning difficulties. Ultrasonography of the abdomen revealed multiple renal cysts of varying sizes in both the kidneys. Dosage analysis of the hepatocyte nuclear factor (HNF)-1β gene by multiplex ligation-dependent probe amplification (MLPA) detected a heterozygous whole gene deletion (p.Met1_Trp557del). This finding is consistent with the diagnosis of renal cysts and diabetes (RCAD) syndrome. This is the first case of the RCAD syndrome reported in an Indian patient. Pediatricians need to be aware of this entity whenever renal disease is seen in a diabetic child in the absence of microalbuminuria or proteinuria.Item Urinary Tract Infection – A Tale of 50 Years.(2016-01) Goel, Srishti; Mukherjee, Sharmila B