Browsing by Author "Mukherjee, M"
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Item Amenorrhoea with I.U.C.D.(1968-02-16) Mukherjee, MItem Blood leucocytes in Mastomys natalensis with filarial infections.(1988-09-01) Mukherjee, M; Reddy, A BItem Carrier detection in non-deletional Duchenne/Becker muscular dystrophy families using polymorphic dinucleotide (CA) repeat loci of dystrophin gene.(2001-01-31) Chaturvedi, L S; Srivastava, S; Mukherjee, M; Mittal, R D; Phadke, S R; Pradhan, S; Mittal, BBACKGROUND & OBJECTIVES: Carrier detection and prenatal diagnosis is of great importance for families with one or more sons affected with Duchenne/Becker muscular dystrophy (D/BMD). In about 35-40 per cent of these patients, the causative mutation does not involve gross rearrangement in the structure of dystrophin gene. In these non-deletional families, genetic counselling can be provided only by linkage analysis. The aim of the present study was to determine the carrier status of female relatives in north Indian families with non-deletional D/BMD using highly polymorphic intragenic dinucleotide (CA) repeat markers. METHODS: Six short tandem repeats (STRs) spanning 5' (1), central (4) and 3' regions of the dystrophin gene were used to analyse 14 unrelated families comprising 68 individuals with 12 female siblings at risk of being carriers. RESULTS: Five female siblings inherited at risk STR haplotype, six inherited normal haplotype and one had meiotic recombination. The intragenic recombinations were observed in three families at the central region STR loci and in one family between the proximal and central regions of the gene. INTERPRETATION & CONCLUSIONS: Our study suggested that at least 6 STR markers spanning 5', central and 3' regions of the dystrophin gene are essential to ascertain one or more informative loci and to rule out recombinations in non-deletional D/BMD families for carrier analysis.Item Central pontine myelinolysis in a normonatremic child.(1997-02-01) Taneja, K; Sabharwal, R K; Taneja, A; Mukherjee, MItem Cytopathological study of bone tumours.(1994-10-01) Mandal, S C; Mukherjee, MFine needle aspiration biopsy is now widely used for detection of any pathological lesions like neoplasm, specific inflammation, cysts, etc. In a study of 22 cases, 17 (77.2%) were diagnosed by aspiration. Specific diagnosis was found in 59% cases and in 18.2% cases suggestive diagnosis was confirmed by histopathological examinations from biopsy materials. Like other investigative methods it is accurate and informative. It is also simple, can be done quickly and cheaper economically.Item Diagnostic evaluation of extrapulmonary tuberculosis by fine needle aspiraton (FNA) supplemented with AFB smear and culture.(2003-10-01) Sinha, S K; Chatterjee, M; Bhattacharya, S; Pathak, S K; Mitra, R Basu; Karak, K; Mukherjee, MOne hundred forty-three patients, 72 males and 71 females, with extrapulmonary tuberculosis were aspirated and subjected to cytological (Ziehl-Neelsen stain) examination and culture in Lowenstein-Jensen media. Routine haematological examination and Mantoux test were done in all the cases, x-ray chest in 112, skeletal x-ray in 3 relevant cases and sputum was examined for AFB in 16 cases where pulmonary tuberculosis was associated/suspected with extrapulmonary tuberculosis. HIV status was evaluated in 51 cases and 9 (7.64%) were seropositive. FNA cytology in 102 cases (71.3%) had caseating epithelioid granulomas while smear for AFB was positive in 57 cases (39.8%). Both culture and smear were positive in 29 (20.2%) cases. Combining both smear and culture yielded positive results in 47.5% cases. It was observed that AFB positivity was higher in untreated patients and with HIV positive cases. Further more, the triad of FNAC, AFB smear and culture were cheaper, foolproof and confirmatory than costlier tests like TB IgG, IgM, RTPCR and BACTEC.Item Diameter of anterior cerebral artery - An anatomical study.(2013-01) Aggarwal, N; Paul, M M; Mukherjee, MBackground & objectives: The anterior cerebral artery is the smaller of the two terminal branches of the internal carotid. The cerebral arteries lie between their origins and their junctions with the corresponding communicating arteries. The haemodynamics of the circle of Willis is influenced by variations in the caliber of the segments of the anterior and posterior cerebral arteries and their communicating arteries. Arteries forming parts of circle of Willis frequently vary in size. Methods: In the present study the diameter of A1 segment of anterior cerebral artery, forming the anterior part of the circle of Willis, is measured in the brains of 50 embalmed cadavers. . The measurements of the diameters of the artery were taken using an electronic digital calliper with 300mm operating instructions (0.001mm accuracy). Results: The anterior cerebral artery at point ‘A ’has a diameter of 2.79mm and 2.39mm on left and right sides respectively and at point ‘B ’ it has a diameter of 2.73mm and 2.38mm on left and right sides respectively. Interpretation & conclusion: The findings suggest that the left anterior cerebral artery has a larger diameter than the right anterior cerebral artery. The information regarding size and co-relation of the considered arteries may be useful for better interpretation of angiographic images and for deeper understanding of cerebral pathology. A knowledge of the normal size of these vessels may also be of use to the surgeon in assessing the feasibility of shunt operations and in the choice of patients.Item Effect of trypsin inhibitors of Streptomyces griseus Cal. on blood clotting and fibrinolysis.(1984-04-01) Mukherjee, M; Mukherjee, K; Thangamani, AItem Effects of DEC on urinary histamine in patients with tropical eosinophilia.(1986-01-01) Mukherjee, M; Vaidya, A B; Paul, T; Satoskar, R SItem Electron microscopic characteristics of actinomycetic agents having aetiological association with human leprosy and epizootic ulcerative syndrome of fish.(1996-08-01) Chakrabarty, A; Mukherjee, M; Chakrabarty, A N; Dastidar, S G; Basak, P; Saha, BThe transmission electron microscopic (TEM) studies of the human leprosy derived chemoautotrophic nocardio-form (CAN) bacteria and EUS derived CAN bacteria showed presence of double contoured cell-walls consisting of an electron transparent and a dense layer. The fibrillar structures on the surface of these CAN bacterial cells also suggested their similarity to the human tissue derived Mycobacterium leprae cells. These EM studies further revealed mycelial and coccoid bodies in all these bacteria as was observed originally.Item Haemorheology on the horizon.(1990-10-01) Mukherjee, M; Shah, S JItem Health and safety in the community. Role of various agencies.(1988-02-01) Mukherjee, MItem Hereditary spherocytosis in North India: need for more extensive data.(2003-10-15) Jijina, F; Ghosh, Kanjaksha; Mukherjee, M; Mohanty, DipikaItem Identification of persons at high risk of coronary heart disease--a mathematical formula based on biochemical, anthropometric and clinical markers.(1996-01-01) Mukherjee, M; Dastur, D K; Soneji, S LA reliable method for identification of the subset of population predisposed to coronary heart disease (CHD) would aid a targetted implementation of intervention strategies. To this end, a mathematical formula was developed based on stepwise linear discriminant analysis. Age, body mass index, the number of associated coronary risk factors and a large number of biochemical markers were analysed by computerised discriminant analysis on a test sample of 203 subjects. Unstandardised canonical discriminant coefficients of statistically significant independent variables were used to derive the total discriminant score or the 'risk score'. The 'low-risk' persons not in need of immediate preventive measures of CHD could be distinguished from the 'high-risk' individuals with an almost 90% correctness. As compared with the existing methods such as clinical evaluation and cardiac stress test, the risk scores derived by the new method, and based chiefly on blood markers besides clinical and anthropometric variables, appeared to correctly predict the future coronary episodes in members of the test sample selected at random. The risk scores were also tested on a new sample of 50 subjects; while low scores were not associated with CHD, high scores in some patients were associated with myocardial ischemia. It appears that the preventive measures of CHD may be directed at people who have no clinical manifestations of CHD, but whose risk scores are greater than 0.1. On the other hand, if the score is less than -1.0, immediate preventive measures may not be necessary. If the score is between -1.0 and 0.1 (borderline), no immediate action may be taken but the score may be determined after six months, and action taken accordingly.Item Incidence of congenital malformations in relation to seasonal variation in West Bengal.(1988-12-01) Roychoudhury, A; Mukherjee, M; Talukder, G; Sharma, AItem Infantile cortical hyperostosis.(1976-04-16) Datta, T; Sarkar, S K; Mukherjee, M; Sen, KItem Influence of haloperidol on testicular functions in rat.(1997-09-25) Mukherjee, M; Ghosh, AThe study involved exploration of the role of dopamine antagonist haloperidol on the testicular functions of rat. Chronic administration of haloperidol (0.2 mg/kg/day/sc for 21 days) caused significant increase in brain DA and serum prolactin. At testicular level the treatment revealed atrophic degeneration of seminiferous epithelium indicating suppression of hypophyseal gonadotrophins and proves importance of dopaminergic control over prolactin release for normal functions of male gonad.Item Isolation, characterization and biological functions of myoinositol trisphosphate generated by phytase action on myoinositol hexaphosphate.(1988-12-01) Maitra, R; Samanta, S; Mukherjee, M; Biswas, S; Biswas, B BItem Limitation of glucose oxidase method of glucose estimation in jaundiced neonates.(2006-03-17) Chaudhuri, Rupak Kr; Mukherjee, M; Sengupta, D; Mazumder, SThe most widely used method for estimation of plasma glucose is that adopted by Trinder's using glucose oxidase-peroxidase (GOD-POD) system. This method gives much lower blood glucose values with blood samples of neonatal jaundice (plasma bilirubin level > 10 mg/dL) of age 10 +/- 5 daysthan with samples of neonates of the same age group without jaundice or older children suffering from other diseases like acute respiratory distress, septicemia.Item Lupus anticoagulant assay: indications, laboratory techniques and therapeutic options.(1991-12-01) Mukherjee, M; Chogle, A R