Browsing by Author "Mitra, S K"
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Item 'Abdominal cocoon'--a cause of intestinal obstruction in a 4 years old girl.(1979-11-01) Rao, P L; Mitra, S K; Pathak, I CItem Abdominal tuberculosis presenting as inguinal hernia.(1983-10-01) Narasimharao, K L; Pradeep, R; Mitra, S K; Pathak, I CItem Acute intestinal obstruction due to gram seed. Report of a case.(1975-01-01) Sahariah, S; Mitra, S K; Pathak, I CItem Acute intestinal obstruction in children as seen in north west India.(1978-12-01) Rao, P L; Sharma, A K; Yadav, K; Mitra, S K; Pathak, I CItem Advanced intussusception--a diagnostic error.(1997-01-01) Mitra, S K; Budhiraja, S; Singh, GItem Ameliorative effect of Partysmart in rat model of alcoholic liver disease.(2008-02-14) Gopumadhavan, S; Rafiq, Mohammed; Azeemuddin, M; Mitra, S KPresent study was designed to investigate the effect of polyherbal formulation PartySmart in experimental model of alcoholic liver disease in male Wistar strain rats. Alcohol plus fish oil were administered to animals for 8 weeks to induce liver injury. PartySmart was administered at doses of 250 and 500 mg/kg body weight. After 8 weeks, parameters such as liver weight, liver function serum markers alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and lipid peroxidation were studied. Livers from all the groups were subjected for histological evaluation. Treatment with PartySmart at the dose of 500 mg/kg body weight showed significant reduction in the levels of serum ALT, AST and ALP with a decrease in liver weight as compared to ethanol-fed rats. A significant decrease was also observed in malondialdehyde levels following treatment with PartySmart at 500 mg/kg body weight. Histological profile of liver tissue in PartySmart-treated animals showed lesser vacuolar degeneration and intactness of hepatic architecture along with improved glycogen deposition as demonstrated by PAS staining. PartySmart ameliorated alcohol-induced liver injury by preventing cell membrane disturbances, reduction of oxidative stress by free radical scavenging and antioxidant activity and normalization of altered intracellular redox status. Thus, PartySmart can be beneficial in the treatment of alcohol-induced liver damage.Item Amoebic liver abscess in children: a report of five cases.(1976-02-01) Das, B N; Mitra, S K; Walia, B N; Mahajan, R C; Pathak, I CItem Anti-cholestatic activity of HD-03, a herbal formulation in thioacetamide (TAA)-induced experimental cholestasis.(1999-04-21) Mitra, S K; Venkataranganna, M V; Gopumadhavan, S; Sundaram, RIn the present study HD-03, a herbal formulation was investigated for its anti-cholestatic activity in TAA-induced cholestasis in anaesthetized guinea pigs. Administration of TAA at a dose of 100 mg/kg body wt significantly reduced the bile flow, bile acid and bile salt excretion. Pretreatment with HD-03 at a dose of 750 mg/kg body wt per orally for 15 days in guinea pigs significantly prevented thioacetamide-induced changes in bile flow, bile acids and bile salts excretion. Thus, HD-03 can serve as a potent choleretic and anti-cholestatic agent.Item Anxiogenic activity of quinine--an experimental study in rodents.(1992-01-01) Bhattacharya, S K; Mitra, S KQuinine, a cinchona alkaloid, was investigated for putative anxiogenic activity in view of clinical reports suggesting that it induces anxiety and apprehension following its use in malaria. The experimental paradigms chosen to elucidate anxiogenic activity have been shown to stand the tests of reliability and validity. Yohimbine, which has been shown to induce anxiety both in animals and in man, was used for comparison. Quinine was found to elicit a complex behavioural profile of activity ranging from overt central stimulation to marked central depression on dose increment. The doses 10 and 20 mg/kg, ip, of quinine chosen to investigate anxiogenic activity were comparable to those induced by 2.5 and 5 mg/kg ip of yohimbine. Quinine induced a dose-related anxiogenic activity in the open-field and elevated plus-maze tests in mice, and the social interaction and thirst conflict tests in rats, similar to effects induced by yohimbine. In addition, both quinine and yohimbine attenuated the effects of diazepam, an anxiolytic agent, in the open-field and thirst conflict tests. The results indicate that quinine exerts significant anxiogenic effect at a particular dose range.Item An approach to assess fertility of Sikkim's population.(1969-10-01) Mitra, S K; Rao, V JItem Beware of psoas abscess.(1988-01-01) Narasimharao, K L; Narasimhan, K L; Mitra, S K; Mehta, SItem Bizarre trichobezoars.(1986-09-01) Saxena, C; Bhat, N; Nagi, B; Narasimharao, K L; Mitra, S K; Mehta, SItem Calculus anuria in a 20 months old child.(1983-03-01) Narasimharao, K L; Mitra, S K; Chugh, K S; Pathak, I CItem Case report: bacillus cereus food poisoning.(1978-04-01) Panhotra, B R; Agarwal, K C; Kaul, T N; Mitra, S KItem Childhood malignant nevus giganticus.(1984-09-01) Mitra, S; Mukhopadhyay, B; Chakraborty, A K; Narasimahrao, K L; Mitra, S KItem Choledochal cysts in infants and children.(1998-07-27) Poddar, U; Thapa, B R; Chhabra, M; Rao, K L; Mitra, S K; Dilawari, J B; Singh, KOBJECTIVE: To study the clinical spectrum and management of choledochal cyst in children below 12 years of age. DESIGN: Descriptive study. SETTING: Tertiary care hospital. METHODS: Twenty three children with choledochal cysts were managed between January 1991 to September 1997 and their clinical details, investigations and management were recorded. Choledochal cyst was diagnosed by ultrasonography and confirmed by ERCP or peroperative cholangioram (POC) Children were treated with antibiotics and/or percutaneous transhepatic biliary drainage if there was cholangitis and subsequently subjected to surgery (excision of the cyst and jejunal loop interposition hepaticoduodenostomy). RESULTS: The median age of these children was 3 years with an almost equal sex ratio. Predominant presentation was jaundice in 18, pain abdomen in 15, fever in 12, and lump abdomen in 9 cases. The classical triad of jaundice, pain and lump was present in only 4 cases. ERCP conducted in 7 and POC in 14 cases yielded positive findings in all. Clinically there were two distinct forms of presentation: (i) infantile form (< or = 1 year) comprised 9 infants which presented with jaundice in all, acholic stool in 6, lump abdomen in 4 but only one had classical triad; and (ii) childhood form (> 1 year) presented with pain abdomen in 12 and jaundice and cholangitis in 9 subjects each. Type I cyst was seen in 20 and type IVa in 3. Two children refused surgery, and the rest underwent surgery. Three infants died after surgery, the remaining 18 were alive and well on follow-up (median 25 months). Secondary biliary cirrhosis was seen in 6, extra hepatic biliary artresia in 2 and congenital hepatic fibrosis in 1 on histology. CONCLUSIONS: Choledochal cysts present in two clinically distinct forms. Infantile form is an important cause of cholestasis of infancy. Early diagnosis and referral is essential to prevent complications and death, and prognosis after surgery is good.Item Chronic secondary caeco-colic intussusception in a boy associated with primary malignant lymphoma of caecum (a case report).(1986-04-01) Yadav, K; Patel, R V; Mitra, S K; Malik, A KItem Colonoscopic polypectomy in children.(1981-11-01) Dilawari, J B; Philip, A; Rao, P N; Malik, A K; Yadav, K; Mitra, S K; Pathak, I CItem Congenital diverticulum and valve obstruction of anterior urethra.(1986-08-01) Narasimharao, K L; Chana, R S; Mitra, S K; Pathak, I CItem Congenital fusion of gums with ankylosis of temporomandibular joints.(1984-08-01) Narasimharao, K L; Mitra, S; Mitra, S K