Browsing by Author "Mishra, S K"

Now showing 1 - 20 of 71
  • No Thumbnail Available
    Item
    Adjuvant therapy in cerebral malaria.
    (2006-09-07) Mohanty, Sanjib; Patel, D K; Pati, S S; Mishra, S K
    Cerebral malaria is the most common cause of non-traumatic encephalopathy in the world. The mainstay of therapy is either quinine or artemisinin, both of which are effective antimalarials. The clinical picture of cerebral malaria may persist or even become worse in spite of the clearance of parasites from blood. The death rate is unacceptably high even with effective antimalarials in tertiary care hospitals. The mortality increases in presence of multi organ failure (renal failure, jaundice, respiratory distress, severe anaemia, lactic acidosis, etc.). The pathogenesis of cerebral malaria is multifactorial and includes clogging, sequestration, rosette formation, release of cytokines, cerebral oedema, increased intracranial hypertension, etc. Attempts are made to use adjuvant therapy which will act through alternate mechanisms and address one or more of the pathogenetic processes. In this review, we have discussed the role of corticosteroids, pentoxifylline, desferrioxamine, mannitol and newer agents in the treatment of cerebral malaria. Though the literature on adjuvant therapy in cerebral malaria is large enough, there are a number of shortcomings in the clinical trials, many being open and non randomized or of very small sample size. Further research is of utmost importance through large multicentric, double-blind controlled trials to show the efficacy of any of these drugs.
  • No Thumbnail Available
    Item
    Adjuvant therapy in invasive thymoma: an audit of cases treated over an 8 year period.
    (1999-03-16) Agrawal, S; Datta, N R; Mishra, S K; Kumar, S; Tandon, V; Ayyagari, S; Agarwal, A
    Invasive thymomas comprise 0.1%-0.2% of all malignancies in India. This report is an audit of 11 cases (10 males and 1 female) at a mean age of 36.6 years (range 25-52 years) of invasive thymoma accrued over an eight year period treated by combined modality treatment. Nine of these presented with myaesthenia gravis. All patients underwent initial surgery (3 partial and 8 total resections) and postoperative radiotherapy. Two of the three partially resected patients received one course of chemotherapy prior to radiotherapy consisting of cyclophosphamide, vincristine, procarbazine and prednisolone. At a median follow up of 28 months (range 2-87) there have been no local relapses, one distant metastasis and one death due to uncontrolled myaesthenia. The treatment strategies with invasive thymomas would depend upon the extent of resection. Postoperative radiotherapy appears to be indicated in all cases, however the role of chemotherapy may be limited to those with partial resection.
  • No Thumbnail Available
    Item
    Adreno-cortical tumors: clinico-pathological profile of five cases.
    (1997-06-01) Agarwal, G; Mishra, S K; Agarwal, A; Bhatia, V
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
    Avirulent mutants of Macrophomina phaseolina and Aspergillus fumigatus initiate infection in Phaseolus mungo in the presence of phaseolinone; levamisole gives protection.
    (2000-03-29) Sett, S; Mishra, S K; Siddiqui, K A
    To evaluate the role of phaseolinone, a phytotoxin produced by Macrophomina phaseolina, in disease initiation, three nontoxigenic avirulent mutants of the fungus were generated by UV-mutagenesis. Two of them were able to initiate infection in germinating Phaseolus mungo seeds only in the presence of phaseolinone. The minimum dose of phaseoli-none required for infection in 30% seedlings was 2 5 mg/ml. A human pathogen, Aspergillus fumigatus was also able to infect germinating seeds of P. mungo in the presence of 5 mg/ml concentration of phaseolinone. Phaseolinone seemed to facilitate infection by A. fumigatus, which is not normally phytopathogenic, by reducing the immunity of germinating seedlings in a nonspecific way. Levamisole, a non-specific immunopotentiator gave protection against infection induced by A. fumigatus at an optimum dose of 50 mg/ml. Sodium malonate prevented the effects of levamisole.
  • No Thumbnail Available
    Item
    Carcinoma in Graves' disease.
    (1995-09-01) Thakur, S; Sharma, A K; Agarwal, A; Mishra, S K; Bhatia, E
    Association of thyroid carcinoma in thyrotoxicosis is uncommon. Preoperative diagnosis of such association is difficult. In a retrospective study of 49 operated cases of Graves' disease (GD) such an association was found in four patients. Findings of a palpable nodule, calcification and a cold nodule on scanning in Graves' disease should increase suspicion for such an association and a frozen section study should be underken in all these cases during surgery to exclude possible co-existing malignancy.
  • Thumbnail Image
    Item
    A Case of Bilateral Tibial Hemimelia Type IV and V with Bilateral Subdural Hygroma and Atrial Septal Defect.
    (2015-01) Kadam, Rahul Vishwasrao; Mishra, S K; Deshmukh, Aniruddha Gajanan; Mukhi, Luv Shyamlal
    Congenital absence of tibia is a rare anomaly, and may be total or partial, unilateral or bilateral. Total absence is more frequent than partial, unilateral absence occurs more often than bilateral, with right limb more commonly affected than the left. In partial defect, almost always the distal end of the bone is affected and, of the bilateral cases, there may be total absence on both sides, or total on one side and partial on the other. Males are slightly more commonly affected than the females. Though, the family history is usually negative for congenital abnormalities and other diseases, there is a considerable chance of occurrence of congenital defect of the tibia or of other abnormalities, in near or remote relatives. We report a case of newborn having bilateral tibial hemimelia type V (right) and IV (left).
  • No Thumbnail Available
    Item
    Coexistence of carcinoma breast and Paget's disease of bone.
    (2008-01-18) Sundaraiya, S; Pradhan, P K; Gupta, A; Jain, M; Mishra, S K; Das, B K
    We report a case of a patient with carcinoma breast who was incidentally diagnosed to be also suffering from Paget's disease of bone on a routine radionuclide bone scan. CT-guided biopsy and histopathology later confirmed the diagnosis.
  • No Thumbnail Available
    Item
    Cyclical mastalgia--is it a manifestation of aberration in lipid metabolism?
    (1994-10-01) Sharma, A K; Mishra, S K; Salila, M; Ramesh, V; Bal, S
    Several therapeutic and investigative studies suggest the possibility of the role of lipid profile aberrations in the pathophysiology of cyclical mastalgia. This prospective study is aimed to look for such aberrations. Fifty-seven patients of benign breast disease were included in this study who were symptomatic for at least 6 months prior to presentation. Detailed serum lipid profile work up was performed on day 1, 15 and 25 of menstrual cycle. The patients with symptoms of maximal severity (or limited to) during leuteal phase of menstrual cycle were included in group I (n = 32). Those who had mastalgia, but did not have above mentioned cyclical variation, were included in group II (n = 25). Since noncyclical mastalgia is a group of heterogeneous disorders of varied etiology, the patients in group II were treated as controls. At day 25, there was an elevation in mean values of HDL-C (P = 0.03) and HDL-C/LDL-C ratio (P = 0.01), and reduction in TC/HDL-C ratio (P < 0.03), in group I. This has not been the case with group II patients. When the patients of mastalgia were treated with low fat dietary regimen, there was a significant difference in the responses of these two groups (P value < 0.0001). Based on the results of lipid profile study and dietary intervention, we conclude that cyclical mastalgia is an entity which is distinctly different from noncyclical mastalgia and needs a different therapeutic approach. Our data, both investigative and therapeutic, suggests that cyclical mastalgia may be a result of cyclical aberrations in lipid metabolism, and the physiological treatment in the form of an appropriate dietary regimen holds a considerable promise.
  • No Thumbnail Available
    Item
    Delivery practices in west Uttar Pradesh.
    (1996-01-01) Nandan, D; Mishra, S K
    The present study has been planned to identify healthy and unhealthy delivery practices in rural U.P. specially with reference to five cleans recommended under national C.S.S.M. programme. A total 120 women who had delivered in recent past were interviewed. Only in 3.1 percent deliveries, proper washing of floor was done, in 43 percent deliveries the cord cutting instrument was not sterilized and in about 65 percent deliveries mustard oil and ghee was used as first cord applicant.
  • No Thumbnail Available
    Item
    Ectopic ACTH syndrome due to bronchial carcinoid tumour--a case report.
    (1998-06-16) Agarwal, A; Mehrotra, R; Mishra, S K; Mithal, A; Jain, M; Gupta, R K
    A patient is reported who had Cushing's syndrome and carcinoid tumour of the bronchus. The case illustrates the difficulty in preoperative localization of the ectopic ACTH source and the surgical management of such patients.
  • No Thumbnail Available
    Item
    Effect of anthelmintics on histamine levels in lungs & intestine of rats infected with Nippostrongylus brasiliensis.
    (1987-02-01) Misra, A; Mishra, S K; Agarwal, A; Katiyar, J C; Ghatak, S
  • No Thumbnail Available
    Item
    The effect of levamisole on the level of biogenic amines in Nippostrongylus brasiliensis.
    (1983-11-01) Agarwal, A; Mishra, S K; Mishra, A; Katiyar, J C; Ghatak, S
  • No Thumbnail Available
    Item
    Effect of nifedipine and dipyridamole on K+ and NA stimulated 45Ca-uptake into rabbit aortic strips.
    (1993-10-01) Parija, S C; Raviprakash, V; Mishra, S K
    The effect of dipyridamole (DPM), a purine nucleoside uptake inhibitor, on the K+ and noradrenaline (NA)-stimulated 45Ca-uptake into Rabbit aortic strips was studied and compared with that of nifedipine (NFD). DPM (10(-6) M) significantly (P < 0.02) inhibited 45Ca-uptake in aortic strips stimulated with K+ (10(-1) M). However, it had less significant effect on NA (10(-4) M)-stimulated 45Ca-uptake. The percentage inhibition was 80 and 57 in K+ and NA-stimulated 45Ca-uptake, respectively. Similarly, NFD (10(-7) M) caused significant (P < 0.01, P < 0.05) decrease in K+ (0.060 +/- 0.009) and NA (0.082 + 0.01, mM)-stimulated 45Ca-uptake. The percentage inhibition by NFD was 98 and 64 in K+ and NA-stimulated 45Ca-uptake, respectively. The results suggest that DPM inhibits Ca2+ influx occurring through Voltage Operated Calcium Channels (VOCCs) but it has little effect on Receptor Operated Calcium Channels (ROCCs).
  • No Thumbnail Available
    Item
    Effects of adenosine on contractility and 45Ca-uptake in rat urinary bladder.
    (1994-11-01) Parija, S C; Raviprakash, V; Mishra, S K
    Effects of adenosine on K+ and ACh-stimulated contractility and 45Ca uptake were studied in the rat urinary bladder smooth muscle and were compared with those of nifedipine. Both adenosine (10(-5) M) and nifedipine (10(-7) M/10(-8) M) significantly inhibited the contractions elicited by K+ (10(-2)-32 x 10(-2) M), Ca2+ (10(-4)-3 x 10(-2 M) in K(+)-depolarized preparations and ACh (10(-9) M-3 x 10(-3) M). Further, adenosine (10(-5) M) significantly (P < 0.05) inhibited K+ (10(-1) M)-stimulated 45Ca-uptake in the bladder strips. However, it had little effect on inward 45Ca movement resulting from ACh (10(-4) M)-induced stimulation. On the other hand, nifedipine (10(-7) M) significantly (P < 0.001) reduced both K+ and ACh-induced 45Ca-uptake in this tissue. It is concluded that the calcium channel blocking action of adenosine is limited to Ca2+ uptake through voltage operated calcium channels, while receptor operated calcium channels activated by muscarinic receptor stimulation appear to be insensitive to the purine.
  • No Thumbnail Available
    Item
    Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.
    (2005-09-29) Mandi, Gurupada; Sarkar, S N; Mishra, S K; Raviprakash, V
    The present study was undertaken to investigate the in vitro influence of mibefradil, a calcium channel blocker, and pinacidil, a potassium channel opener, on pregnant goat myometrial spontaneous rhythmic contractility and contractions induced with the agonist, oxytocin. Longitudinal strips from the distal region of uterus, collected from goats at midgestation, were mounted in an organ bath for recording isometric contractions. Mibefradil (10(-8)-10(-4) M) or pinacidil (10(-10)-10(-4) M), added cumulatively to the bath at an increment of 1 log unit, caused concentration-dependent inhibition of the spontaneous rhythmic contractions of isolated uterine strips. The rhythmic contraction was, respectively, abolished at 100 and 10 microM concentrations of mibefradil and pinacidil. In a concentration-dependent manner, mibefradil (1 and 10 microM) antagonized the contractions elicited with oxytocin (10(-5)-10(-2) IU). Pretreatment of uterine strips with glibenclamide (10 microM), a selective KATP channel blocker, caused a rightward shift of the concentration-response curve of pinacidil with a concomitant decrease in its pD2 value. Pinacidil (0.3, 1 and 3 microM), in a concentration-related manner, antagonized the oxytocin (10(-5)-10(-2) IU)-induced contractile response. The inhibition of spontaneous rhythmic contractions and antagonism of oxytocin-induced contraction by mibefradil in the pregnant goat myometrium may be related to the antagonism of voltage-dependent Ca2+ channels, while by pinacidil suggests that KATP channel could be a therapeutic target for tocolysis.
  • No Thumbnail Available
    Item
    Effects of oxidizing and reducing agents on ovine pulmonary artery responses to nitric oxide donors, sodium nitroprusside and 3-morpholino-sydnonimine.
    (2006-12-21) Sardar, K K; Sarkar, S N; Bawankule, D U; Mishra, S K; Raviprakash, V
    Nitrovasodilators-sodium nitroprusside (SNP; 10(-9)-10(-4) M) and 3-morpholino-sydnonimine (SIN-1; 10(-9)-10(-4) M) produced concentration-dependent relaxation of the fourth generation sheep pulmonary artery, preconstricted with 5-hydroxytryptamine (1 microM). Oxidizing agents [oxidized glutathione (GSSG, 1 mM) and CuSO4 (5 and 20 microM)] and reducing agents [dithiothreitol (DTT, 0.1 mM), ascorbic acid (1 mM) and reduced glutathione (GSH, 1 mM)] caused opposite effects on nitric oxide (NO)-induced vasodilation in the artery. Ascorbic acid and GSH potentiated the NO responses, while GSSG and CuSO4 inhibited relaxation caused by the nitrovasodilators. DTT, however, reduced the relaxant potency and efficacy of SNP and SIN-1. Pretreatment of the pulmonary artery strips with DTT (0.1 mM) inhibited SNP (10 microM)-induced Na(+)-K(+)-ATPase activity, while ascorbic acid (1 mM) and GSH (1 mM) had no effect either on basal or SNP (10 microM)-stimulated 86Rb uptake, an index of Na(+)-K(+)-ATPase activity, in ovine pulmonary artery. The results suggest that reducing agents like ascorbic acid may have beneficial effect in improving the vascular function under oxidative stress.
  • No Thumbnail Available
    Item
    Efficacy of low fat diet in the treatment of benign breast disease.
    (1994-03-01) Mishra, S K; Sharma, A K; Salila, M; Srivastava, A K; Bal, S; Ramesh, V
    BACKGROUND. Previous studies have shown that lipid abnormalities have a role in the pathogenesis of benign breast disease. However, few investigators have tried to reduce dietary fat to treat this disorder. METHODS. Between 1990 and 1993, we conducted a prospective cohort study to find out the efficacy of a low fat diet (less than 15% fat-derived calories) in the treatment of benign breast disease in patients who had been symptomatic for 6 months or more. The study was conducted in two phases. In the first phase 36 patients were alternately assigned to control and treatment groups for 6 months and in the second phase 121 patients (including all those in phase I) were given treatment (median follow up 25 months, range 3 to 39 months). Detailed lipid profiles were studied at the time of presentation and at 4 and 5 months. RESULTS. Phase I results showed that after 6 months none of the patients in the control group had experienced any alteration in their symptoms and signs but in the treatment group 12 out of 17 improved. In phase II improvement in pain (68 out of 97; 70%), nodularity (51 out of 79; 64%) and discharge (15 out of 19; 80%) was seen. There was a significant decline in the mean values of total cholesterol and high-density lipoproteins at the end of 5 months of treatment. CONCLUSION. A low fat diet improves the symptoms as well as the lipid profile in patients with benign breast disease.
  • No Thumbnail Available
    Item
  • No Thumbnail Available
    Item
    Evaluation of the activity of receptor-operated Ca2+ channels in rat portal vein in induced hyperthyroidism.
    (1999-07-25) Reddy, A G; Mishra, S K; Prakash, V R; Tandan, S K; Tripathi, H C; Varshney, V P
    The activity of receptor-operated Ca2+ channels (ROCCs) was studied in rat portal vein in L-thyroxine-induced experimental hyperthyroidism. The following parameters were evaluated: 1. NE-stimulated 45Ca influx. 2. CaCl2-induced contractile responses in Ca2+ free NE-stimulated tissues to calculate EC50 value of CaCl2. The NE (10(-6)mol) stimulated 45Ca influx and the mean EC50 value of CaCl2 did not differ significantly in portal veins isolated from hyperthyroid rats as compared to those of euthyroid control rats. The study revealed no significant change in the functional status of ROCCs in experimental hyperthyroidism.