Browsing by Author "Mishra, Nigamananda"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Effect of endometrial scratch injury on pregnancy rate after previously failed intrauterine insemination(Medip Academy, 2024-02) Keskar, Jagruti Ratnakar; Prabhu, Santoshi Ramkrishna; Savani, Gayatri Vishal; Mishra, Nigamananda; Jadhav, Vaishali Rohan; Bhenki, Deepak SubhashBackground: Endometrial receptivity plays an important role in implantation and successful pregnancy. In literature, various attempts have been made to improve endometrial receptivity. Endometrial scratch injury (ESI) is one such intervention widely offered to improve endometrial receptivity in women with a history of in-vitro-fertilization (IVF) failure. In our present study, this procedure of ESI was performed in cases with previously failed intrauterine insemination (IUI) and its effect on pregnancy rate was assessed.Methods: A prospective, randomised, controlled study was conducted at Fertility Clinic, Bhabha Atomic Research Centre Hospital, Mumbai. Total 200 women requiring IUI with previously failed one IUI were included in the study. They were randomly divided into 2 groups of 100 each. Both the groups underwent controlled ovarian stimulation with clomiphene citrate and gonadotropins followed by IUI. Study group underwent “endometrial scratching” in mid-proliferative phase of the same cycle preceding IUI. Control group underwent IUI alone. Pregnancy rates (clinical and ongoing) were compared in both the groups.Results: Endometrial scratching group had significantly higher (<0.0002) (8.4±2.3 mm versus 7.3±1.9 mm) endometrial thickness at the time of ovulation trigger. Clinical pregnancy rate was significantly higher (p<0.0001) (42% versus 16%) in endometrial scratching group with no significant difference in ectopic pregnancy, miscarriage and multiple pregnancy rates in both the groups.Conclusions: Due to its role in improving pregnancy rates in women with previously failed IUI, clinicians should offer ESI in mid-proliferative phase of the same cycle preceding IUI, before offering advanced IVF treatment.Item Perinatal outcome of term pregnancies with borderline amniotic fluid index: a prospective case control study(Medip Academy, 2020-05) Desai, Devika V.; Mishra, Nigamananda; Savani, Gayatri V.Background: It has been since antiquity that the importance of amniotic fluid and fetal growth with perinatal outcome is being documented. But the lacunae lies in studying the relationship between borderline amniotic fluid and perinatal outcome. The following study was undertaken to provide recent data that would help predict perinatal outcome in borderline AFI pregnancies.Methods: About 144 patients were considered in the study OPD/IPD patients in obstetrics and gynecology department in Bhabha Atomic Research Centre and Hospital, with about 72 cases with borderline amniotic fluid index (5-8 cm) and controls with amniotic fluid index ≥9-25 cm. Patients were selected and subjected to history taking, examination, ultrasound test with doppler studies and perinatal outcome documented over a period of one year.Results: The incidence of borderline AFI in my study was 16%. 58% were primigravidas. Meconium stained liquor was found in 18% cases compared to 7% controls. Low birth weight was found in 12.5% cases and 2.7% in controls. On applying statistical test analysis chi square test, it was found that borderline amniotic fluid index in relation to presence of meconium stained amniotic fluid and low birth weight, p value was found to be statistically significant (<0.05).Conclusions: Borderline amniotic fluid and perinatal outcome had significant relationship in terms of meconium stained liquor and birth weight while rest had no significance. Thus, borderline amniotic fluid patients require vigilant fetal surveillance.