Browsing by Author "Mishra, Mayank"

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    Parvovirus B19 Induced Fulminant Liver Failure In Pregnancy: A Rare Incidence
    (Atharva Scientific Publications, 2019-09) Majumdar, Avirup; Atam, Virendra; Mishra, Mayank; Sharma, Deepak; David; Shivhare, Shubhanshu
    Parvovirus B19 (B19V) is a single-stranded DNA virus of the family Parvoviridae and genus Erythrovirus. Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. The majority of the available literature regarding acute parvovirus B19 induced fulminant hepatic failure has described cases involving children.Acute fulminant liver failure caused by acute parvovirus B19 infection in a pregnant lady is rarely reported in the literature. Here, we report a case of fulminant liver failure in a 28-year-old pregnant lady presenting as a diagnostic dilemma, the etiology of which was eventually detected as acute Parvovirus B19 infection. Since Parvovirus B19 is a potential cause of non-A, non-E fulminant hepatic failure, an early diagnosis is of utmost importance as treatment options are limited
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    Test-retest Repeatability and Minimal Detectable Change of 1-minute Sit-to-Stand Test for the Ability to Detect Exercise-induced Oxygen Desaturation in Patients with Interstitial Lung Diseases
    (Jaypee Brothers Medical Publishers Pvt. Ltd., 2024-06) Panjiyar, Vickey; Sharma, Prakhar; Banerjee, Saikat; Sanjan, Ganesh; Bahurupi, Yogesh A; Joshi, Narayan; Dua, Ruchi; Saini, Lokesh K; Mishra, Mayank; Sindhwani, Girish
    Background: While methods like the 6-minute walk test, shuttle walk test, and cardiopulmonary exercise testing (CPET) are available to assess exercise limitation, they need a large space to perform/advanced lab settings which makes 1-minute sit-to-stand test (1STST) a feasible option in office practice. Data on test-retest reliability and the minimal detectable change (MDC) of 1STST is lacking in both national and international literature. Materials and methods: In this prospective observational study, our objective was to assess test-retest reliability and the MDC of the 1STST in patients with ILD and to determine the correlation of 1STST with the severity of interstitial lung disease (ILD) by spirometry and mGAP index. Results: A total of 65 ILD patients underwent 1STST during the study duration. The mean number of repetitions during the test retest 1STST and were 20 ± 6 and 21 ± 6 respectively (p = 0.029). The intraclass correlation coefficient (ICC) between a number of repetitions during 1STST and retest 1STST was 0.914 with SEM of 1.551 repetitions and a MDC of 4 repetitions. Statistically significant poor correlation was observed between test and retest 1STST repetitions with diffusion capacity of lung for carbon monoxide (DLCO) predicted z score (r = 0.428 and p = 0.006). modified gender age lung physiology index score (r = –0.195, p = 0.142), SpO2 drop (r = –0.301; p = 0.013), BMI of patients (r = –0.287; p = 0.02), and baseline hemoglobin level (r = –0.095; p = 0.504) had a negative poor correlation with number of repetitions during 1STST. Conclusion: The 1-minute sit-to-stand test is a valuable tool for detecting exercise-induced desaturation in ILD patients, showing reliability and a MDC of approximately 4 repetitions.