Browsing by Author "Mathur, K B"
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Item Adjuvant activity of some nonpyrogenic hydrophobic analogues of muramyl dipeptide in enhancing the primary humoral and cell mediated immune responses in guinea pig model.(1991-02-01) Saxena, R P; Puri, A; Saxena, K C; Shukla, R; Haq, W; Rizvi, S Y; Kundu, B; Mathur, K BFive muramyl dipeptide analogues synthesized by derivatization of gamma-carboxyl of D-isoglutamine residue of MDP into alkyl amides or incorporation of lysine residue at the site via epsilon-NH2 function were evaluated for immuno-adjuvant activity. Derivatization of gamma-carboxyl of D-isoglutamine into butyl, octyl and dibutyl residues stimulated delayed type of hypersensitivity (DTH) response, the maximum stimulation being observed with octyl amide. Introduction of lauryl amide residue abolished DTH response. The antibody response was impaired with all the alkyl amide analogues except for the lysyl amide derivative with which the response was higher than MDP. Correlation was observed between DTH response and macrophage migration.Item Antiarrhythmic and antithrombotic effect of antiarrhythmic peptide and its synthetic analogues.(1988-11-01) Dikshit, M; Srivastava, R; Kundu, B; Mathur, K B; Kar, KItem Antilipolytic activity of some arginine peptides.(1977-12-01) Mathur, K B; Kishore, V; Kapoor, N K; Nityanand, SItem Antiviral activity of some new cationic polyamino acids.(1982-03-01) Mathur, K B; Gangopadhyay, A K; Chowdhury, B L; Babbar, O PItem A cyclic tetrapeptide with antiimplantation activity.(1974-03-01) Mathur, K B; Rishi, S; Dhar, M M; Kamboj, V P; Kar, A BItem A mechanism for the distinction of foreign proteins by living systems based on peptide directed RNA synthesis.(1973-09-01) Dhar, M M; Agrawal, A K; Mathur, K B; Ray, CItem Morphine-like activity of some N-substituted amides of met-enkephalin.(1989-09-01) Raghubir, R; Patnaik, G K; Dhotre, B J; Mathur, K B; Dhar, M M; Dhawan, B NOpioid activity of a homologous series of met-enkephalin alkylamides was analysed. In guinea pig ileum test, the hexylamide derivative was most active, whereas the isopropylamide derivative was most potent in analgesia test. The results suggest that structural changes of this type at the C-terminus of the pentapeptide improve the opioid activity.Item Morphine-like activity of substituted amides & imides of [D-Ala2, Met5]-enkephalin.(1989-04-01) Raghubir, R; Patnaik, G K; Sharma, S D; Dhotre, B J; Mathur, K B; Dhawan, B NSix enkephalin analogues (N-substituted amides and imides of [D-Ala2, Met5]-enkephalin) were synthesized and tested for opioid activity. All the compounds, except one i.e., compound IV, showed analgesic activity which was much higher than Met-enkephalin and morphine in mice and inhibited electrically induced contractions of isolated guineapig ileum, [D-Ala2, Met5]-enkephalin-morpholide and [D-Ala2, Met5]-enkephalin-beta-Ala-amide were the most potent analgesics and nearly 6 and 500 times as active as morphine and Met-enkephalin respectively. Both the compounds were equipotent on the guineapig ileum preparation, whereas the beta-Ala-amide was about twice as active as the morpholide in the electrically stimulated mouse vas deferens preparation.Item A study of anti-semliki forest virus activity of poly N epsilon-(2-aryl-2-thiazoline-4-carbonyl-L-lysines) in mice.(1977-03-01) Kant, R; Chandra, K; Gupta, B M; Mathur, K B; Kishore, V; Dhar, M MItem Synthesis & biological activity of peptides related to insulin structure.(1980-08-01) Mathur, K B; Kishore, V; Kundu, B; Srivastava, R C; Kapoor, N K; Mukherjee, S KItem Synthesis & hypoglycemic activity of arginine peptides.(1980-08-01) Mathur, K B; Kishore, V; Srivastava, R C; Mukherjee, S KItem Synthesis and hypoglycemic activity of peptides related to insulin fragment B22-25.(1987-12-01) Kundu, B; Srivastava, R C; Mathur, K B; Mukherjee, S KItem Synthesis of poly(Glu-Ala-Ala-Ala-Ser) and poly(Ala-Ala-Glu-Ala-Ser) as model receptors for acetylcholine.(1973-12-01) Chakravarty, P K; Mathur, K B; Dhar, M MItem Synthesis of substitute enzymes.(1978-02-01) Mathur, K B; Dhar, M M