Browsing by Author "Marya, R K"
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Item Acute effects of neurogenic stress on urinary electrolyte excretion.(1987-07-01) Marya, R K; Sood, S; Lal, H; Malik, V; Saini, A SPlasma Cortisol and urinary excretion of water, sodium, potassium, calcium and magnesium have been studied in the rat after application of 2 types of neurogenic stress:--(a) tight rubber band tourniquet and (b) electric shock. Plasma cortisol levels increased significantly after application of either type of stress. During both type of stress, there was statistically significant increase in the urinary excretion of water, sodium and calcium but not of potassium and magnesium. Urinary calcium/magnesium ratio was also significantly elevated. The results suggest that stress may be one of the factors involved in the genesis of urolithiasis.Item Amygdalar injections of vasopressin and its antagonist do not disrupt the circadian rhythm of food and water intake in the rat.(1988-04-01) Reghunandanan, V; Marya, R K; Maini, B K; Reghunandanan, RThere is an indication that areas of the brain other than the suprachiasmatic nuclei (SCN), the known neural circadian pacemaker, are involved in the control of circadian rhythms. The present study investigated the role of amygdala in the circadian rhythms of food and water intake. Vasopressin and its antagonist d(CH2)5Tyr(Me)AVP were injected into the amygdala bilaterally through chronically implanted stainless steel cannulae. The results of the study have shown that neither vasopressin nor its antagonist d(CH2)5Tyr(Me)AVP alters the circadian rhythm of food and water intake thereby showing that vasopressinergic neurons/projections to amygdala are not involved in the control of circadian rhythms of food and water intake and amygdala is not likely to be an additional oscillator.Item Azotemic osteodystrophy.(1971-02-01) Marya, R KItem Bilateral suprachiasmatic injection of naloxone disrupts circadian rhythm of food intake.(1988-12-01) Reghunandanan, V; Marya, R K; Maini, B K; Reghunandanan, RItem Capillary permeability during menstrual cycle.(1973-09-01) Mahajan, K K; Marya, R K; Maini, B K; Bajaj, V RItem Comparison of effects of naloxone and catecholamines on acid-base balance in canine hemorrhagic shock.(1990-04-01) Reghunandanan, R; Marya, R K; Singh, G P; Maini, B K; Reghunandanan, VThe present study was conducted to compare the effect of naloxone, an opiate receptor antagonist, with catecholamines on acid-base status and survival in dogs subjected to hemorrhagic shock. Arterial lactic acid concentration which had increased during hemorrhage, decreased significantly (P less than 0.05) in naloxone treated animals but increased further in catecholamine treated dogs. Blood bicarbonate concentration and PCO2 which had markedly decreased 1 hr after hemorrhage recovered significantly (P less than 0.05) in naloxone group of animals. On the other hand bicarbonate and pH declined further in noradrenaline group and remained unchanged in dopamine group. These results as well as better survival rate observed in naloxone treated animals suggest the superiority of naloxone over dopamine and noradrenaline, as an adjunct to blood transfusion in the treatment of hemorrhagic shock.Item Drinking water as a source of dietary calcium.(1981-01-01) Marya, R KItem Effect of acute environmental heat stress on urinary water and electrolyte excretion in the rat.(1988-04-01) Marya, R K; Sood, S; Lal, H; Sharma, A; Saini, A SPlasma cortisol and urinary excretion of water, sodium, potassium, calcium and magnesium have been studied in the rat after application of heat stress. There was a significant increase in plasma cortisol level after exposure to heat. During heat stress complete cessation of urine formation was observed. In the next 30 min there was statistically significant increase in the urinary excretion of water, sodium and calcium but not of potassium and magnesium. Urinary calcium/magnesium ratio was also significantly elevated. The increase in urinary water and electrolyte excretion seemed to be mediated through prostaglandins since it could be abolished by administration of indomethacin prior to the application of heat stress. On the basis of these results, the possible role of heat stress in the genesis of urolithiasis has been discussed.Item Effect of cold challenge on alveolar capillary blood volume in normal individuals.(1990-10-01) Mishra, N; Marya, R K; Mahajan, K KThe effect of immersion of both the hands and the feet in water at 10 degrees C on lung transfer factor for carbon monoxide (Tlco) and on pulmonary capillary blood volume (Vc) was investigated in 20 normal young adult males immediately, 60 min and 120 min after the end of the cold challenge. Vc was significantly reduced immediately and the reduction was aggravated at 60 min. Tlco was significantly reduced only at 60 min. All the values returned to baseline at 120 min. It is concluded that the cold-induced changes in Tlco and Vc are physiological responses and not unique to patients with Raynaud's phenomenon as suggested by some workers.Item Effect of graded doses of naloxone on renal function in canine hemorrhagic shock.(1992-04-01) Reghunandanan, R; Reghunandanan, V; Marya, R KAll the parameters of renal function (inulin clearance, para amino hippuric acid clearance and urine flow) which were depressed during experimentally induced hemorrhagic shock in dogs improved significantly in addition to improvement in mean arterial pressure (MAP) after bolus administration (iv) of 1 or 2 mg/kg naloxone. A smaller dose (0.5 mg/kg) of naloxone, however, did not improve the renal function. Even renal arterial injection of the same dose of naloxone showed no improvement in the renal function. In both these cases the improvement in the MAP was significantly less as compared to other groups of animals which received 1 or 2 mg/kg naloxone. It may be concluded that (a) naloxone at doses of 1 or 2 mg/kg improved the renal function by improving MAP and (b) naloxone has no direct action on renal vasculature.Item Effect of hyponatraemia on taste threshold for salt in hypertensive subjects.(1985-05-01) Marya, R K; Sood, S; Sood, A K; Maini, B KItem Effect of naloxone & catecholamines on renal function & survival in haemorrhagic shock in dogs.(1988-05-01) Reghunandanan, R; Marya, R K; Maini, B K; Reghunandanan, VItem Effect of naloxone on renal cortical microcirculation in haemorrhagic shock.(1991-06) Reghunandanan, R; Reghunandanan, V; Marya, R KIn order to assess the effect of opioid receptor antagonists, naloxone and noradrenaline, on renal cortical microcirculation, India ink infusion was made through the renal artery, one hour after treatment with each drug, in dogs subjected to haemorrhagic shock. Naloxone (1 mg/kg) treatment showed a dual beneficial effect of significant improvement (P < 0·001) in the mean arterial pressure without increasing the renal resistance as indicated by the presence of ink particles in about 75% of the cortical glomeruli. However, in the case of noradrenaline (2 μg/kg/min)-treated animals, although mean arterial pressure increased significantly (P < 0·001) only very few glomeruli (25%) in the cortical region showed ink particles, demonstrating severe vasoconstriction. In the control group infused only with saline, although most of the glomeruli (92%) were filled with ink particles, there was a significant decline in the mean arterial pressure (P < 0·001).Item Effect of vitamin D supplementation during pregnancy on foetal growth.(1988-12-01) Marya, R K; Rathee, S; Dua, V; Sangwan, KItem Effect of vitamin D supplementation in lactating rats on the neonatal growth.(1991-07-01) Marya, R K; Saini, A S; Lal, H; Chugh, KIn lactating rats consuming a commercial diet adequate in calcium, phosphorus and vitamin D, the effect of supplementation of 3000 IU and 7,500 IU of vitamin D3 on the lactational performance of the dams and soft tissue and skeletal growth in the pups has been investigated. On 28th day of age, the pups in the supplemented groups were significantly heavier than in the control group. Study of the indices of cellular growth in the liver and gastrocnemius muscle revealed that the increase in the soft tissue weight was due to a significant increase in protein, RNA and DNA contents (cellular hyperplasia) without any change in protein/DNA ratio (cell size). In the tibia, compared to controls, the dry bone weight and ash weight were more in the supplemented groups, but ash weight/dry bone weight ratio was not altered. The improvement in the neonatal growth was most probably due to the greater milk yield observed in the dams in supplemented groups and not due to any anabolic effect in the pups since direct administration of 500 IU or 1,000 IU of vitamin D3 in 10 day old pups did not increase their body weight.Item Growth patterns of school children in Rohtak area.(1979-04-01) Manocha, K K; Marya, R KItem High excretion of parahydroxy phenyl acetic acid in normal individuals.(1970-12-01) Saini, A S; Singh, P C; Marya, R K; Garg, B B; Singh, I DItem Hypercalcemic crisis: diagnosis and treatment.(1973-01-01) Marya, R KItem Mechanism of hypercalciuria in experimental metabolic acidosis.(1980-10-01) Marya, R K; Dadoo, R C; Khurana, S; Keshwani, R K; Chhabra, H LTo study the mechanism of hypercalciuria in metabolic acidosis, ammonium chloride loading (long) test was performed in 68 stone formers and 50 controls. Administration of ammonium chloride in both stone formers and controls produced a significant increase in urinary volume, ammonium and calcium excretions, no change in plasma calcium and creatinine clearance and significant decrease in plasma bicarbonate. However, on the third day of ammonium chloride loading test, urinary ammonium excretion and plasma bicarbonate levels were significantly lower while urinary calcium excretion was significantly greater in stone formers than in controls. Thus calciuresis could be correlated with the degree of metabolic acidosis but not with the rate of urinary ammonium excretion.Item Osteomalacia in Hindu population of Haryana.(1981-05-01) Marya, R K; Saini, A S; Rathee, S; Arora, S R