Browsing by Author "Manzoor, Sheikh"
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Item Bullous icthyosiform erythroderma with rickets in child of a parent with naevus unius lateralis.(2010-03) Bhat, Yasmeen J; Baba, Asif Nazir; Manzoor, Sheikh; Qayoom, Seema; Ahmed, Sheikh MushtaqItem Dexamethasone-cyclophosphamide pulse therapy in pemphigus.(2009-03-19) Manzoor, Sheikh; Bhat, Yasmeen; Ahmad, Shabir; ,; ,Item Ellis-van Creveld syndrome with facial hemiatrophy.(2010-05) Bhat, Yasmeen J; Baba, Asif Nazir; Manzoor, Sheikh; Qayoom, Seema; Javed, Sheikh; Ajaz, HakeemEllis-van Creveld (EVC) syndrome is a rare autosomal recessive congenital disorder characterized by chondrodysplasia and polydactyly, ectodermal dysplasia and congenital defects of the heart. We present here a case of a 16-year-old short-limbed dwarf with skeletal deformities and bilateral postaxial polydactyly, dysplastic nails and teeth, also having left-sided facial hemiatrophy. The diagnosis of EVC syndrome was made on the basis of clinical and radiological features. To the best of our knowledge, this is the first report of EVC syndrome with facial hemiatrophy in the medical literature from India.Item Evaluation of Corticosteroid and Methotrexate Therapy in the Treatment of Moderate to Severe Localized Scleroderma (Morphoea) – A 5 Year Study in a Teaching Hospital of North India(International Society for Contemporary Medical Research, 2019-05) Qayoom, Seema; Rather, Suhail; Manzoor, Sheikh; Sameen, FarahIntroduction: Localized scleroderma is a rare disorderwith not well recognized aetiology. Though consideredto be a benign disorder it may result in a severe cosmeticdisfigurement or even functional disability. There is no proveneffective therapy for localized scleroderma so far makingmanagement of such cases challenging. Lack of evidencebased treatment and standardization of evaluation methodsmay be reason for it. The Study was conducted to evaluatethe role of corticosteroid and methotrexate therapy in ourpopulation with severe localized scleroderma (morphoea).Material and Methods: All patients attending with OPD inDepartment of Dermatology SKIMS-MCH from Jan, 2014,to Jan, 2019, with clinical features suggestive of active,moderate to severe morphoea were enrolled in the study. Adetailed clinical history was followed by a thorough clinicalexamination and calculation of LoSSI score. Patients werestarted on i/v methyl-prednisolone 30mg/kg monthly pulsesas 3 consecutive doses for 3 months (maximum 1gm) andintramuscular MTX at 0.2 to 0.4 mg/kg/week (maximum 25mg/week) for 12 months.Results: A total of 21 patients were included in the study.Male: Female ratio was 1:3.2. Mean age was 21.19years.Linear morphoea was most common type (13 cases) followedby plaque morphoea (6 cases). There was a significantdecrease in mean LoSSI score (from 15.19 to 6.62) at 4months after completion of steroid methotrexate phase (valueof t is -8.621425, value of p is < .00001). Mean LoSSI scoreafter completion of 12 months of treatment was 0.94 (valueof t is -9.644953, value of p is < .00001). The treatment waswell tolerated.Conclusion: The study suggests that systemic corticosteroidsand methotrexate in combination is effective and well toleratedtreatment for both adults and children with localized moderateto severe scleroderma.Item Trace element levels in alopecia areata.(2009-01-28) Bhat, Yasmeen J; Manzoor, Sheikh; Khan, A R; Qayoom, SeemaBACKGROUND: Alopecia areata (AA) is a recurrent, nonscarring type of hair loss considered to be an autoimmune process. Though its etiopathology is not fully understood, there are claims that imbalance of trace elements may trigger the onset of AA. AIM: The aim of the present study was to assess the levels of zinc, copper, and magnesium in the serum of AA patients. METHODS: Fifty AA patients (34 men and 16 women), and fifty age and sex matched healthy control subjects were studied. Samples were analyzed using atomic absorption spectrometric methods. RESULTS: Serum zinc levels were significantly decreased (P < 0.05) in AA patients whose disease was extensive, prolonged, and resistant to treatment, whereas serum copper and magnesium levels showed insignificant rise compared to controls. CONCLUSION: We conclude that copper and magnesium levels are not altered in AA, but the decreased zinc levels found in our study may merit further investigation of the relationship.