Browsing by Author "Mandal, A"

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    Assessment of efficacy of Anti-IgE (Omalizumab) therapy in patients with severe allergic asthma in a tertiary care hospital of Eastern India
    (Siddharth Health Research and Social Welfare Society, 2019-06) Ghosh, S; Gayen, P; Mandal, A; Bandyopadhyay, R
    Introduction: Immunoglobulin E dependent mechanisms play an important role in the development of airway inflammation in allergic asthma. Atopic patients with severe asthma frequently have poorly controlled disease. Many have poor asthma control despite intensive treatment. Severe allergic asthma patients frequently treated with oral corticosteroids and therefore may develop serious side-effects. Anti-IgE antibody had been used in severe persistent allergic asthma in Western countries. However, its long-term efficacy in patients in India has not been reported. Objective: To assess the efficacy of anti IgE therapy in patients with severe allergic asthma. Method: 30 (16 male and 14 female) patients, with mean age of 49 having severe persistent allergic asthma, with recurrent exacerbations and on oral/IV steroids, received Omalizumab 150mg/300mg/450 mg for 1 year. Total dose of oral Steroids, use of rescue medications, changes in lung function (FEV1) were recorded at the baseline, 16 weeks & at end of the treatment (52 weeks) and then analyzed. Results: Significant reduction observed in total oral steroid use at 16 week & at 52 weeks. -10.5mg (p<0.003) & 22.5mg respectively. Use of rescue medications decreased by -7.90 puffs(p- <0.001) at 16 weeks and by -13.67 puffs (13.67 (p -<0.001) at 52 weeks. Improvements in lung Function (FEV1) observed with a tune of 700 ml. from Baseline after 52 weeks therapy. Conclusion: Use of anti-IgE antibody for 1 year is well tolerated and led to an overall significant improvement in patients with severe persistent allergic asthma.
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    Assessment of etiology and pharmacotherapy of patients with anemia in chronic myeloid leukemia: Challenges and opportunities in a tertiary care government hospital
    (?Eldaghayes Publisher, 2024-12) Jana, R; Baul, SN; Saha, S; Chattopadhyay, S; Mandal, A; Ghosh, A.
    Background: Chronic Myeloid Leukemia (CML) is the most prevalent blood malignancy in India. Anemia, spleno- megaly, weight loss, fatigue are the most common symptoms and Imatinib, a first generation Tyrosine kinase inhibitor (TKI) is the choice of treatment. Aim: The objective of the study was to assess the etiology of anemia in CML and the pattern of pharmacotherapy, medication adherence, and adverse drug reaction (ADR) in these patients in a tertiary care government hospital. Methods: This cross-sectional observational study was conducted between January 2023 and May 2024 on 40 pa- tients of all age groups and of both sexes, presented with CML and anemia to the outpatient department of hematology. General, hematological and cytogenetic investigations were done to assess the outcome of treatment. Drug adherence and ADRs were also assessed. Results: Of the participants 25% were male and Imatinib mesylate, was the mainstay of treatment (92%) which is supplied free of cost. A high rate of medication adherence was noted (85%). A total of 70 ADRs were noted among the patients participating in the study commonest being anemia (55%). Conclusion: Anemia remains a major problem in the management of CML patients and needs continuous assessment and management.
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    Authors’ response.
    (2015-01) Sugunan, A P; Bhattacharya, Haimanti; Bhattacharya, Debdutta; Mandal, A; Ghosal, S R; Rao, R C; Mandal, A K
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    Authors’ response.
    (2016-02) Pahari, S; Roy, S; Mandal, A; Kuila, S; Panda, S
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    Bacterial pollution in hospital potable drinking water supplies.
    (1987-01-01) Mohan, V P; Mandal, A
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    Bullous pemphigoid associated with the use of DPP4 inhibitors: A case series
    (?Eldaghayes Publisher, 2024-09) Saha, M; Bandyopadhyay, M; Mandal, A; Ghosh, A; Mandal, P; Chattopadhyay, S.
    Dipeptidyl-peptidase 4 (DPP-4) inhibitors are one of the most commonly used anti-diabetic drugs because of their established safety and efficacy. Bullous pemphigoid which is an autoimmune blister skin disorder associated with DPP-4 inhibitors is a recognized adverse drug reaction (ADR) reported in some Southeast Asian Nations but has not been reported earlier from India. It is an uncommon, serious treatment with emergent adverse effects. Here, we report a series of five cases of DPP-4 inhibitor Linagliptin-induced bullous pemphigoid reaction in Type 2 diabetes mellitus patients. We are reporting five cases that showed various clinical manifestations in terms of gender (males 4), duration of diabetes (average 7.2 years), glycemic control (average HbA1C 6.7%), and latency period (average 3.6 weeks) for development of the ADR. Quality of life and treatment satisfaction were severely impacted by this ADR. Withdrawal of Linagliptin, use of topical and oral steroids and immunosuppressant like azathioprine were prescribed and effective for improving the lesions of all the cases. As per the World Health Organization-Uppsala Monitoring Center scale, causality was established as “probable” for all the cases. This case series serves to bring to the notice of prescribers regarding this important cutaneous ADR with the use of Linagliptin. This case intends to improve awareness among clinicians regarding the possibility of this cutaneous ADR among diabetic patients to facilitate early diagnosis and intervention.
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    Cadmium resistance in some members of Enterobacteriaceae.
    (1989-06-01) Bhattacharyya, G; Chaudhuri, J; Bhakta, S; Mandal, A
    Strains of members of Enterobacteriaceae, namely Escherichia coli (18), Klebsiella aerogenes (16), and Serratia marcescens (16) were screened for Cd resistance or sensitivity. Only one strain each of these was resistant to high levels (25 n moles/0.05 ml) CdCl2. The Minimal inhibitory concentration (MIC) of sensitive strains ranged from 0.8-5 micrograms/ml. All the resistant strains were simultaneously resistant to a number of antibiotics. Treatment with sodium dodecyl sulfate eliminated resistance to Cd and to some antibiotics.
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    Clinico-radiological profile and outcome of patients undergoing intercostal tube drainage in a tertiary care hospital in West Bengal, India
    (Siddharth Health Research and Social Welfare Society, 2019-12) Hassan, MI; Ghosh, S; Agarwalla, A; Mandal, A
    Introduction: Evacuation of empyema which was first performed centuries ago, marked the beginning of thoracic drainage. The subsequent acquisition of a greater knowledge of the anatomy, physiology, and pathology of the pleural space directed the design of thoracic catheters and drainage systems and the development of the methods by which they are used. Thoracic drainage systems are designed to remove air and liquids from the pleural space or mediastinum, which collect there as a result of injury, disease, or surgical procedures. Method: A total of 100 patients who underwent intercostal tube drainage due to various etiologies are followed up for 3 months in the study Results: In this study it was observed that pneumothorax (67%) as the most common indication for chest drain insertion followed by hydro-pneumothorax. During this period 100 patients of different pathologies related to chest underwent chest intubations. Amongst them 88(88%) were male and 12(12%) were female. Subcutaneous emphysema was found to be the most common complication followed by ICD tube blockage. Among the study population 95% patients were successfully treated & unsuccessful outcome was only 5%. Conclusion: Chest tube insertion is a common procedure usually done for the purpose of draining accumulated air or fluid in the pleural cavity. Small-bore chest tubes (≤14F) are generally recommended as the first-line therapy for spontaneous pneumothorax in non-ventilated patients and pleural effusions in general. Large-bore chest drains may be useful for very large air leaks, as well as post-ineffective trial with small-bore drains.
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    A clinicopathological study of pleural effusion with special reference to malignant aetiology in a tertiary care hospital in West Bengal
    (Siddharth Health Research and Social Welfare Society, 2019-08) Kumar Bar, P; Mandal, S; Banik, T; Barman, R; Mandal, A
    Background: Pleural effusion has varied aetiological factors. It constitutes one of the major causes of morbidity in India as well in other parts of world. Because of the various aetiologies that can cause pleural effusion, itoften present a diagnostic problem, even after extensive investigations. Objective: In this study, authors aimed to identify the common aetiologies causing pleural effusion and their clinical profile in a tertiary care hospital. Materials and Methods: A hospital based cross-sectional study is conducted over a period of one year in tertiary care hospital in West Bengal. 150 patients of pleural effusion above 10 yrs of age were studied. Clinico-pathological, radiological, hematological and biochemical parameters were documented. Results: The most common cause pleural effusion in this study was tuberculosis (64.67%), followed by malignancy (14.67%), parapneumonic effusion (7.33%), cardiac failure (5.33%) and other minor causes. It was commonly seen in male (70%). The occurrence of tubercular pleural effusion was maximum in the age group 31-40 years. Right-sided effusions were more common. Pleural fluid cytology and adenosine deaminase played a pivotal role in the diagnosis of tubercular pleural effusion. Conclusion: The present study highlights tuberculosis as the common causative factor for pleural effusion, labels lung carcinoma as the most common cause of malignant pleural effusion, and defines the clinico-pathological, biochemical and imaging characteristics of different aetiologies of pleural effusion.
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    Comparison of Vitek Yeast Biochemical Card with conventional methods for speciation of Candida.
    (2000-04-24) Sood, P; Mishra, B; Dogra, V; Mandal, A
    The ability of the Vitek Yeast Biochemical Card to identify yeast isolates was compared with conventional methods. Of the fifty yeast isolates tested same species identification was obtained in thirty-four isolates. The Vitek yeast biochemical card identified 13 isolates which could not be identified by the conventional tests. Though the Vitek Yeast biochemical card gave a good rapid identification the high cost of each test severely limits its routine use in most of the laboratories.
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    Coverage evaluation surveys amongst children in some blocks of West Bengal.
    (1990-10-01) Mukherjee, B; Ray, S K; Kar, M; Mandal, A; Mitra, J; Biswas, R
    Immunisation coverage evaluation was carried out in 9 Blocks of West Bengal amongst 12-23 months old children. Fully immunised status of 5 blocks were under 16%. Poor measles vaccine coverage thought to be the reason. Other vaccine coverage was more than 60%, in most of the blocks excepting Hilly Balurghat and Tamluk. "Child ill-not brought" was the important reason for immunisation failure in most of the blocks.
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    Dengue hemorrhagic fever in Calcutta.
    (1994-06-01) Banik, G B; Pal, T K; Mandal, A; Chakraborty, M S; Chakravarti, S K
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    Detoxification of mercury and organomercurials by nitrogen-fixing soil bacteria.
    (1989-06) Ray, S; Gachhui, R; Pahan, K; Mandal, A; CHAUDHURY, J
    Minimal inhibitory concentration values of HgCl2 and 5 organomercurials were determined against 24 mercury-resistant N2-fixing soil bacteria previously isolated from soil and identified in our laboratory. These bacterial strains also displayed multiple antibiotic resistant properties. Typical growth pattern of a highly mercury-resistant Beijerinckia sp (KDr2) was studied in liquid broth supplemented with toxic levels of mercury compounds. Four bacterial strains were selected for determining their ability to volatilize mercury and their Hg-volatilizing capacity was different. Cell-free extracts prepared from overnight mercury-induced cells catalyzed Hg2+-induced NADPH oxidation. Specific activities of Hg2+-reductase which is capable of catalyzing conversion of Hg2+ →Ηg (o) of 10 Hg-resistant bacterial strains are also reported.
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    Disinfectants and their level of action.
    (1984-04-01) Choudhry, M; Mandal, A; Sharma, K B
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    An epidemiological study of the risk factors of occupational diseases in coal handling plant of a thermal power station.
    (2003-04-08) Manna, A; Bisoi, S; Mandal, N C; Mandal, A
    Anthropometry and morbidity profile of fifty randomly selected workers of coal handling plant at a thermal power station of West Bengal having at least five years experience were studied. The mean value of their age, duration of present job and Body Mass Index (BMI) were 34.8 years, 7.86 years and 19.24 respectively. As they were exposed to coal dust (Av. concentration 300-350 mg/M3 of air), warmth (Ambient temperature 40 +/- 5 degrees C), humidity (Relative humidity 80 +/- 5%) and noise [Av. 80 dB(A)], respiratory system was most commonly (72%) effected followed by greying of hair (5.6%), Cloth dusters used by some could not render any discernable protective effect. Addiction was also prevent (62%). Use of proper protective equipments (PPE) supplemented by adequate preplacement and periodic medical examination followed by successful rehabilitation were suggested.
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    Evaluation of pulse polio immunization in some districts of West Bengal & Assam.
    (2004-04-16) Dobe, M; Ray, S K; Biswas, R; Mandal, A; Meheta, P; Baishya, A C; ,; ,
    A cross-sectional non-interventional survey was carried out in 5 districts of West Bengal and one district of Assam to find out the extent of coverage during IPPI. It was observed that in the recent rounds of IPPI, more than 95% coverage was observed in all the surveyed districts excepting in 24 Parganas South where coverage was around 92%. Situation at the Goalpara district further needed attention, as the coverage during February 03 as well as in the past two rounds were 90.13%, 88.13%, and 91.04% respectively. In all these districts booths were the main sites for IPPI dose though 1/3rd to 1/4th of the beneficiaries received immunization at home also. It was also observed that around 10% of the beneficiaries were not administered any PPI dose in the either of the rounds, in 24 Parganas (south) & Murshidabad districts, from where maximum number of Poliomyelitis cases were reported. At Goalpara it was 19%. Main reason for not being covered with PPI doses in either of the rounds in all the districts excepting Kolkata was "Not aware of the need for additional doses". In Kolkata "child sick" was the main reason. Health workers were main source of information of PPI in South 24 Parganas (67.13%), Malda (58.25%) & West Midnapur (54%). At Murshidabad "announcement through mike" (61.25%) was the main source of information while in Kolkata, TV was the main source (67.13%). Miking (56.38%) was the main source of information for PPI at Goalpara district of Assam. It was observed that involvement of multiple methods & media of communication was helpful in disseminating dates & other information of PPI.
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    Exocrine differentiation of trichoepithelioma & desmoplastic trichoepithelioma; a scanning electron microscopic study.
    (1993-04-01) Mandal, A K; Mandal, A
    Trichoepithelioma is widely thought to be a benign appendage tumour which arises from hair follicles (i) Scanning electron microscopy reveals that the basement membrane of Trichoepithelioma & desmoplastic Trichoepithelioma is similar to the basement membrane of exocrine glands like sweat or sebaceous gland. The basement membrane of Trichoepithelioma and desmoplastic Trichoepithelioma do not show any difference in their structure. Thus, possibly Trichoepithelioma and desmoplastic Trichoepithelioma arises from exocrine gland and are closely related to each other.