Browsing by Author "Malyusz, M"

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    Concentration and dilution power of the kidney in Burmese subjects
    (1968-01-01) Malyusz, M; Nwe Nwe San; Sein Oo
    Urine concentration and dilution were examined in healthy young Burmese subjects in 21 exercise and 29 rest experiments carried out during the monsoon and the cooler period of the year. The effect of deprivation of fluid with and without exogenous vasopressin and that of forced fluid intake were studied. During 22 hours of dehydration at rest the average urine osmolality of the 2 hr collection period ranged between 600 and 1100 mOsm/1 and in few samples was the osmolality above 1200 mOsm/1. Exogenous vasopressin did not raise the urine osmolality significantly. Urine osmolalities suring exercise without fluid intake were lower than those attained during rest. Maximal free water reabsorption was within the normal range. In all dehydration experiments extremely low urea clearance values were found. Experiments with forced fluid intake produced maximally dilute urines indicating efficient diluting mechanism of the kidney in Burmese subjects in case of positive water balance. Low urea load and possibly low GFR are suspected as causes of the inability of subjects to achieve higher urine concentration.
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    The run-out of p-aminohippurate from kidney slices of white rats in the presence of papaverine
    (1968-05-01) Malyusz, M; Hla Win, Bani
    Papaverine in vitro in the concentration of 10 minus power 4 M had no effect on the release of PHA from rat kidney slices at 28? C, when the medium was changed every 30 sec during the 10 min of the experiment : the rate constant of the slow component of the run-out in the control experiments was equal to 0.1441 min minus power 1, lthat of the papaverine treated series equaled to 0. 1674 min minus power 1. In using 5 min intervals for transferring instead of 30 sec the rate constant of the papaverine-free series was significantly lower than that of the papaverine-treated one : 0.091 min minus power 1 versus 0.0731 min minus power 1. There exists a direct relationship between the lost amount of PAH during the 30 sec intervals and actual total PAH-concentration of the kidney slices. Papaverine has no effect on the run-out of PAH at 28? C, because at this temperature the PAH-release is due to processes not requiring energy. At the same time papaverine blocks the reaccumulation of the released PAH. Papaverine affects the in vitro movement of PAH in the kidney slices by inhibiting the uptake of PAH.