Browsing by Author "Mahajan, Aarti M."

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    Comparative evaluation of quality of life in oral cancer patients undergoing 3-dimensional conformal radiation therapy with or without concomitant chemotherapy – A longitudinal study
    (Wolters Kluwer – Medknow, 2024-09) Parate, Prajakta M.; Mahajan, Aarti M.; Prakash, Nilima; Pradeep, GL; Harnekar, Shirin H.; Sadhwani, Vaishali A.
    Objectives: To assess and compare the quality of life (QOL) in Oral Cancer patients undergoing 3?DCRT with or without concomitant Chemotherapy at three different time intervals. Materials and Methods: This unicentric longitudinal study included 50 patients of oral cancer undergoing 3?DCRT with or without concomitant chemotherapy. QOL was recorded using the EORTC H and N 35 Questionnaire at baseline, end of treatment (EOT), and 3 months after treatment. Results: Maximum deterioration of most QOL domains were noted at End of treatment (EOT) in all the patients. A highly statistically significant difference was noted between different time intervals with the highest scores noted at the EOT (P < 0.01). There was a statistically significant difference in patients undergoing 3DCRT with chemotherapy when compared to those with 3DCRT without chemotherapy (P < 0.05). Conclusion: There is substantial deterioration in QOL at the EOT after head–neck irradiation by 3?DCRT with or without concomitant Chemotherapy although it gradually improves over time. However, 3DCRT results in clinically meaningful and statistically better QOL scores at 3 months after treatment compared to baseline and EOT.