Browsing by Author "MS, U"

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    ACUTE TOXICITY STUDY OF ARSENICUM ALBUM IN WISTAR ALBINO RATS
    (Innovare Academic Sciences Pvt. Ltd., 2024-12) A, M; S, B; S, V; AT, SV; MS, U; A, V; TM, K.
    Objective: In India, homeopathic medicines derived from arsenic trioxide, such as Arsenicum album (A. album), are used to treat COVID-19. Many of the Arsenicum album's adverse events during the COVID treatment led to drug discontinuation. Nonetheless, Ayurvedic, Yoga and Naturopathy, Unani, Siddha, and Homoeopathic (AYUSH) medicine prescribes it. Researching Arsenicum album's toxicity is now essential since it will help decide whether or not the drug can be utilized during treatment. Methods: Acute oral toxicity was performed in Wistar Albino Rats to find out the effects of Arsenicum album in various organs. Rats were divided into three groups: Group A (control), Group B (Arsenicum album 1000?l/100g) and Group C (2000?l/100g). A Single bolus dose of Arsenicum album was given orally and the study period was conducted for 14 d. The rats were subsequently sacrificed on the 15th d and biochemical and histopathological studies were done. Results: The acute oral toxicity study showed median Lethal dose (LD50) was greater than 2000?l/100g for Arsenicum album. Biochemical analysis showed a significant increase in HDL level in Group C (2000?l/100g) compared to Group A (control) and Group B (1000?l/100g). [P<0.05]. Blood glucose, when compared to Group A (control) is increased in both groups B and C but statistically not significant (p>0.05). When compared to Group A (control) there is no significant change in blood urea level in Groups B and C (p>0.05). Serum creatinine is increased in Groups B and C compared to Group A (control) but statistically not significant (p>0.05). LDL cholesterol is increased in groups B and C compared to Group A (control) but statistically not significant (p>0.05). Macroscopic examination of the organs of Group B and C revealed no abnormalities when compared with the organs of Group A (control). Histopathological analysis showed mild hepatocellular and renal toxicity in Groups B and C with extensive hemorrhages and periportal lymphocytic infiltrates.
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    Perspectives of parents and caregivers about vaccination during COVID-19 pandemic: An online cross-sectional study
    (?Eldaghayes Publisher, 2024-11) Arunnair, V; S., B; AT, SV; MS, U; Mutalik, AV; Selvamalar, JA.
    Background: The most economical preventive health measure to safeguard youngsters from vaccine-preventable diseases, ensure a disease-free future, and prevent socio-economic disasters is immunization. The coronavirus disease (COVID-19) pandemic led to a major backslide in childhood vaccinations. Hence, it is important to assess the parental knowledge, attitudes, and practices (KAP) towards childhood vaccination amid the prevailing pandemic. Objectives: This study evaluated the KAP of parents and caregivers about immunization. Materials and methods: A prospective cross-sectional online questionnaire (Google Form)-based study was done using convenient sampling among 105 parents and caregivers at a tertiary care hospital in Coimbatore for 6 months. Descriptive and inferential statistics (ANOVA, Chi-square, Pearson correlation test, and Unpaired t-test) were used. The results were depicted in terms of numbers and percentages. The data obtained was evaluated using Statistical Package for the Social Sciences, version 28 for Windows. Results: The mean KAP scores of parents/caregivers about vaccination were 4.99 ± 2.05, 10.63 ± 2.28, and 6.67 ± 1.77, respectively. 61.9%, 58.1%, and 52.4% had good KAP scores, respectively. Participants’ knowledge and atti- tude showed a positive correlation (p < 0.032); however, there was no significant relationship between knowledge and attitude with practice. Urban residents and employed respondents had better attitude and practice scores than rural (p < 0.029) and unemployed (p < 0.033) correspondingly. Conclusion: The population under investigation had a good level of KAP; nevertheless, a gap was noticed in practice. Enhancing the study population’s awareness through educational campaigns and effective communication could help overcome these obstacles and ensure adequate immunization practices.