IMSEAR Repository :: Browsing by Author "Lokhandwala, Y Y"

Browsing by Author "Lokhandwala, Y Y"

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Adenosine-induced ventricular fibrillation.
(2001-03-29) Shah, C P; Gupta, A K; Thakur, R K; Hayes, O W; Mehrotra, A; Lokhandwala, Y Y
The use of adenosine has been suggested as a diagnostic tool in the evaluation of wide ORS complex tachycardia. However, adenosine shortens the antegrade refractoriness of accessory atrioventricular connections and may cause acceleration of the ventricular rate during atrial fibrillation. We observed ventricular fibrillation in 2 patients who presented to the emergency department with pre-excited atrial fibrillation and were given 12 mg of adenosine.
Age at onset, gender distribution and intraarterial blood pressure changes in atrioventricular node-dependant tachycardias.
(1999-04-25) Kavthale, S S; Vajifdar, B U; Naik, A M; Vora, A M; Lokhandwala, Y Y
OBJECTIVE: Atrioventricular nodal reentrant tachycardia (AVNRT) and atrioventricular reentrant tachycardia (AVRT) utilising accessory pathways constitute the vast majority of paroxysmal supraventricular tachycardia (SVT). We studied the age at onset, the gender distribution and the intraarterial hemodynamics of these tachycardias. METHODS: The data of 224 patients who underwent electrophysiology study (EPS) and radiofrequency ablation was analysed. The age at onset of tachycardia was assessed by a careful history. The intraarterial BP was noted during sinus rhythm (SR), immediately after tachycardia onset (T0) and 15 seconds after the onset of tachycardia (T15). RESULTS: The age at onset of tachycardia was a decade later for AVNRT (48 +/- 10 years) than for AVRT (37 +/- 11 years). There was no gender preponderance in the AVNRT group (60 males, 56 females) while a male preponderance was seen in the AVRT group (71 males, 37 females, p < 0.01). There was a marked fall in the intraarterial systolic BP in both groups at the onset of tachycardia, from 143 +/- 24 mm Hg to 108 +/- 16 mm Hg (p < 0.05) for AVNRT and from 139 +/- 25 mm Hg to 107 +/- 18 mm Hg (p < 0.05) for AVRT. There was no correlation between the rate of tachycardia and the extent of fall of BP. CONCLUSION: Hospital-based data in an Indian setting found a similar pattern of age of onset of AV node-dependant tachycardia as in Western literature. However, unlike in Western studies, no female preponderance was seen in the AVNRT group. The fall in systolic BP at the onset of tachycardia is significant, similar in the two groups and independent of the rate of tachycardia.
Anthropometry, lipid profile and dietary pattern of patients with chronic ischaemic heart disease.
(1999-10-29) Vajifdar, B U; Goyal, V S; Lokhandwala, Y Y; Mhamunkar, S R; Mahadik, S P; Gawad, A K; Halankar, S A; Kulkarni, H L
The anthropometry, lipid profile and dietary characteristics of 114 patients with chronic ischaemic heart disease (IHD) were evaluated. There were 91 (80%) men and the mean age was 56 +/- 9 years. The body mass index was near normal (24.4 +/- 3.4), but the waist: hip ratio was high (0.94 +/- 0.06) suggesting central obesity. This was well in accordance of the step II recommendations of the NCEP guidelines as regards their caloric intake and its break-up in terms of carbohydrate, protein and fat (including saturated, mono-unsaturated and poly-unsaturated fatty acids) content. Their daily cholesterol intake (31 +/- 32 mg/day, range 4-180) was very low. The total cholesterol (212 +/- 37 mg%) was marginally elevated, HDL cholesterol (33 +/- 7.5 mg%) was low, LDL cholesterol (148 +/- 39 mg%) was high and the total: HDL ratio (6.8 +/- 2.0) was significantly abnormal. The serum triglyceride level (154 +/- 68 mg%) was on the higher side of normal. These observations give further credence to the recently evolving view that there are different and hitherto unrecognised risk factors of IHD in Indians, who seem to have the highest incidence of IHD amongst all ethnic groups of the world despite consuming a diet low in fat and cholesterol content.
Arrhythmogenic right ventricular dysplasia: electrophysiologic and morphologic features in nine patients.
(1998-07-03) Naik, A M; Vora, A M; Lokhandwala, Y Y; Shah, S
Arrhythmogenic right ventricular dysplasia is a potentially life-threatening disorder, not previously well described in India. We analysed the electrocardiographic, electrophysiologic, angiographic, signal-averaged electrocardiogram and magnetic resonance imaging features of nine patients having arrhythmogenic right ventricular dysplasia at our centre. There were seven males and two females, aged 25 to 55 years. Eight patients presented with sustained monomorphic ventricular tachycardia. The electrocardiogram showed prolonged QRS duration in four, T inversion in leads V2-V3 in four, and epsilon wave in two patients. Abnormal late potentials were present in eight patients. During electrophysiologic study in seven patients, 13 different VTs were induced. Seven patients had right ventricular dilatation and dysfunction and left ventricular involvement was seen in three patients. Eight patients were treated with amiodarone, including one who received an implantable cardioverter-defibrillator. At a follow-up of 8.6 +/- 5.3 months, there was no death, while one patient had recurrence of ventricular tachycardia. Arrhythmogenic right ventricular dysplasia seems to predominantly affect middle-aged men, the presentation most often being sustained monomorphic ventricular tachycardia. Depolarisation and/or repolarisation abnormalities in the electrocardiogram are commonly present. Multiple ventricular tachycardia morphologies during electrophysiologic study and abnormal right ventricular angiograms are usually observed.
Atrial fibrillation: how effectively can sinus rhythm be restored and maintained after balloon mitral valvotomy?
(2000-09-21) Kavthale, S S; Fulwani, M C; Vajifdar, B U; Vora, A M; Lokhandwala, Y Y
Atrial fibrillation, commonly associated with rheumatic mitral stenosis, worsens the prognosis. We studied the efficacy of achieving and maintaining sinus rhythm in patients with chronic atrial fibrillation who underwent a successful balloon mitral valvotomy. Fifty-four patients (26 men, 28 women; age 36+/-8 years) received amiodarone 200 mg thrice daily in the first week, and thereafter a maintenance dose of 200 mg once daily. Electrical cardioversion was attempted at 1 and 3 months and patients were followed up at 6, 12 and 18 months. At the end of 1, 3, 6, 12 and 18 months 81 percent, 72 percent, 60 percent, 54 percent and 49 percent of patients, respectively, were in sinus rhythm. Only one patient had a severe adverse effect (hypothyroidism). Univariate analysis revealed that lower age, shorter duration of atrial fibrillation and smaller left atrial size was associated with successful restoration to sinus rhythm. On multivariate analysis, the duration of atrial fibrillation was the only significant predictor of long-term maintenance of sinus rhythm. Amiodarone seems safe and reasonably effective in restoration and maintenance of sinus rhythm in patients of atrial fibrillation with rheumatic heart disease.
Atrioventricular nodal reentrant tachycardia with atrioventricular block.
(2000-07-29) Pandurangi, U M; Hameed, S; Vora, A M; Lokhandwala, Y Y
Balloon angioplasty for native aortic coarctation.
(1992-07-01) Kale, P A; Lokhandwala, Y Y; Kulkarni, H L; Dalvi, B V; Sathe, S V; Rajani, R M; Mehan, V K; D'Silva, S A
From May 1987 to August 1990, eighteen patients underwent balloon angioplasty for native aortic coarctation. The age of the patients ranged from four to fifty six years (mean age 17.5 years). The procedure was successful in all cases with a reduction in the peak gradient across the coarctation from 61 +/- 19 mm Hg to 11.7 +/- 8.1 mmHg (p < 0.05). The coarcted segment increased from 4.5 +/- 1.9 mm to 10.7 +/- 3.9 mm (p < 0.05). Peak gradient at six to twelve months follow up, obtained in ten patients, was 19.8 +/- 10.1 mmHg (p = NS). There were no life threatening complications, although seven patients had local vascular problems after the procedure. In two patients, there was persistence of hypertension necessitating drug therapy. On haemodynamic and angiographic restudy in 10 patients, one patient had restenosis and none had aneurysm formation. We conclude that balloon angioplasty is a safe, and less invasive alternative to surgery for native aortic coarctation with gratifying immediate and short term results.
Catastrophic WPW syndrome in a 13-month child: cure by radiofrequency ablation.
(1997-10-06) Naik, A M; Lokhandwala, Y Y; Nabar, A A; Dalvi, B V
Does radiofrequency ablation increase creatine kinase and troponin-T?
(1999-07-05) Gupta, A; Halankar, S; Vora, A M; Lokhandwala, Y Y
Radiofrequency ablation produces a focal area of myocardial necrosis. Creatine kinase (total & MB fraction) and troponin-T were analysed in 54 patients who underwent electrophysiological study and radiofrequency ablation for atrioventricular nodal reentrant tachycardia, atrioventricular reentrant tachycardia and idiopathic ventricular tachycardia. The age of the patients was 36 +/- 12 years; 17 patients underwent slow pathway modification for atrioventricular nodal reentrant tachycardia, 26 patients underwent accessory pathway ablation and 11 patients underwent ablation for idiopathic ventricular tachycardia. There was no significant rise in creatine kinase, creatine kinase total & MB fraction and troponin-T in the patients who underwent slow pathway ablation for atrioventricular nodal reentrant tachycardia. In patients with atrioventricular reentrant tachycardia, there was no significant rise in creatine kinase and creatine kinase total & MB fraction levels, while troponin-T levels rose from 0.13 +/- 0.06 to 0.29 +/- 0.16 eta g/ml (p < 0.05). There was an increase in creatine kinase, creatine kinase total & MB fraction and troponin-T levels after idiopathic ventricular tachycardia ablation from 68.4 +/- 44.9 to 138.0 +/- 81.7 IU (p < 0.05), 2.77 +/- 3.34 to 25.2 +/- 19.8 IU (p < 0.05) and 0.09 +/- 0.04 to 0.34 +/- 0.08 eta g/ml (p < 0.001) respectively. Radiofrequency ablation of atrioventricular nodal reentrant tachycardia does not cause any significant myocardial damage to raise any cardiac enzymes. Ablation of atrioventricular reentrant tachycardia results in only minor injury causing rise in only troponin-T levels. However, ventricular tachycardia ablation results in significant myocardial injury raising all the cardiac enzymes.
Early intrinsic deflection--a marker for successful radiofrequency ablation of overt accessory pathways.
(1996-03-01) Lokhandwala, Y Y; Smeets, J L; vd Steld, B; Narula, D D; Stockman, D; Wellens, H J
Precise localization of accessory pathways (APs) is crucial to minimize radiofrequency (RF) energy applications in the Wolff-Parkinson-White (WPW) syndrome. Although several markers have been described for identifying APs, no gold standard has thus far been established. The present study attempted to validate the hypothesis that an early intrinsic deflection (ID) would be identifiable in the unipolar ventriculogram, if this was recorded at or near the site of endocardial breakthrough of the AP. The electrograms of 23 patients with the WPW syndrome who underwent RF ablation were analysed using a computer-based system. A total of 50 electrograms (19 successful and 31 unsuccessful RF energy applications) were studied. The downstroke of the unipolar ventriculogram was measured at 1 msec intervals for the dV/dt; the maximal dV/dt (the most rapid segement of the downstroke) was considered as the ID. The following parameters were found to differentiate between successful and unsuccessful RF ablation attempts: (i) Timing of the ID relative to the delta wave onset (ID-delta = plus 11 +/- 21 msec versus minus 18 +/- 22 msec, p < 0.001). (ii) Timing of the ID relative to the onset of the unipolar ventriculogram (Vu-ID = 14 +/- 7 msec versus 29 +/- 15 msec, p < 0.001). (iii) Maximal dV/dt in the initial 20 msec of the unipolar ventriculogram (367 +/- 146 microV/msec versus 207 +/- 97 microV/msec, p < 0.001). The other parameters (probable AP potential, bipolar ventriculogram timing, continuous electrical activity, unipolar signal morphology) were not helpful in this regard. Hence, the identification of the ID and measurement of its timing is helpful in localising overt APs for successful delivery of RF energy.
Electrocardiographic differentiation between right coronary and left circumflex coronary arterial occlusion in isolated inferior wall myocardial infarction.
(1999-05-07) Gupta, A; Lokhandwala, Y Y; Kerkar, P G; Vora, A M
The presence of atrioventricular block and ST segment elevation in lead V4R accurately predicts right coronary artery occlusion in patients with inferior wall myocardial infarction. However, these electrocardiographic signs are absent in the majority of patients with inferior myocardial infarction. We studied ST segment elevation in leads II and III, ST segment in lead I and T wave polarity in lead V4R in order to differentiate between right coronary artery and left circumflex coronary artery occlusions in 104 patients with inferior myocardial infarction who subsequently underwent coronary angiography. The ST segment elevation was greater in lead III than in lead II when the right coronary artery was the culprit vessel and vice versa when the left circumflex was the culprit vessel (p < 0.001). An upright T wave in lead V4R and ST segment depression in lead I was common when the right coronary artery was the culprit vessel and not seen with left circumflex occlusion (p < 0.001). ST segment elevation in lead III was higher than in lead II with a sensitivity of 99 percent and a specificity of 100 percent for diagnosing right coronary artery as the culprit vessel. ST segment elevation in lead II was higher than in lead III with a sensitivity of 93 percent and a specificity of 100 percent in identifying the left circumflex as the culprit vessel. Thus, these signs are very useful in identifying the culprit vessel in inferior myocardial infarction.
Heart rate variability.
(1994-07-01) Lokhandwala, Y Y; Rodriguez, L M
Idiopathic ventricular tachycardia--characterisation and radiofrequency ablation.
(1994-11-01) Lokhandwala, Y Y; Smeets, J L; Rodriguez, L M; Metzger, J; Grekas, G F; Chaginikolaou, H; Meijer, A; Wellens, H J
Forty patients (14 women and 26 men; mean age 40 +/- 13 years, range 7 to 60) diagnosed to have idiopathic ventricular tachycardia (right ventricular 28, left ventricular 12) underwent electrophysiologic study and radiofrequency catheter ablation. Echocardiography, signal averaging, magnetic resonance imaging and cardiac catheterisation with angiography were used as indicated to rule out identifiable underlying etiologies. Gross localisation of the area of origin of the ventricular tachycardia from the surface electrocardiogram could be made in all cases. Accurate localisation of the site of origin was done by activation mapping and pace mapping. Radiofrequency application was successful in achieving a cure in 34 (85%) patients, with a mean of 8.3 +/- 4.7 energy applications and a fluoroscopy time of 38 +/- 19 minutes. Unsuccessful cases were characterised by wide and slurred QRS complexes during ventricular tachycardia, possibly indicating a deeper intramyocardial or epicardial site of origin of the tachycardia. Radiofrequency ablation appears to be the treatment of choice for symptomatic idiopathic ventricular tachycardia, having a high success and safety rate.
Is dietary fiber beneficial in chronic ischemic heart disease?
(2000-09-24) Vajifdar, B U; Goyal, V S; Lokhandwala, Y Y; Mhamunkar, S R; Mahadik, S P; Gawad, A K; Halankar, S A; Kulkarni, H L
OBJECTIVES: To evaluate the benefit of a dietary fiber preparation (Fibernat) in patients with chronic ischemic heart disease (IHD). METHODS: From January 1997 to March 1998, 114 consecutive patients with chronic IHD were enrolled in this prospective double blind randomized placebo controlled trial. The fiber (F) and placebo (P) groups were comparable at baseline. All patients were given advice regarding dietary and lifestyle modifications. Concomitant drug therapy was not altered. The drug (consisting of soluble and insoluble fibers obtained from fenugreek, guar gum and wheat bran) and placebo were administered for six months (10 grams twice daily). RESULTS: The following parameters improved in both groups: HDL cholesterol (32 to 39 mg/dl, p < 0.0009 in F and 33 to 38, p < 0.007 in P), total: HDL cholesterol ratio (6.7 to 5.6, p < 0.0007 in F and from 7.0 to 6.0, p < 0.01 in P) and weight (64.0 to 63.0 kg, p < 0.002 in F and 60.3 to 59.5, p < 0.002 in P). The Apolipoprotein B increased (101 to 129 mg/dl, p < 0.00001 in F and 98 to 127, p < 0.0008 in P). The following parameters improved only in group F: LDL cholesterol (146 to 134, p < 0.027), Apolipoprotein A-1 (105 to 139, p < 0.001), body mass index (24.9 to 24.5, p < 0.03) and waist circumference (37.2 to 36.7, p < 0.03). Total cholesterol, VLDL cholesterol, triglycerides, hip circumference, W:H ratio, exercise time and blood sugar were unchanged in both groups. CONCLUSIONS: Fibernat is well tolerated, safe and had favorable effects on LDL cholesterol, Apolipoprotein A-1, body mass index and waist circumference.
Is haemorrhagic myocardial infarction more common with streptokinase?
(1997-07-01) Naik, A M; Nabar, A A; Lokhandwala, Y Y; Kulkarni, H L; Deshpande, J R; Sivaraman, A
Autopsy reports and clinical data of 226 consecutive myocardial infarction deaths in whom postmortem studies could be carried out during the period 1980 to 1996 were analyzed retrospectively for the presence of haemorrhagic myocardial infarction (HMI). Of 53 autopsies done from 1980 to 1986 [prior to use of streptokinase (SK) therapy in our institution] none of the specimens showed haemorrhagic infarction. Of 173 autopsies done from 1987 to 1996 (intravenous SK therapy was utilised in this period), 20 specimens showed haemorrhagic infarctions. Sixteen of these 20 patients had received SK, while 66 of the remaining 153 non-haemorrhagic myocardial infarction patients received SK (statistically significant association of SK with HMI, p < 0.005). Acute mechanical complications [ventricular septal rupture (n = 10), papillary muscle rupture (n = 2), cardiac free wall rupture (n = 7)] were seen in 19 cases. Of these, 16 were HMIs and 14 of these patients had received streptokinase. These observations suggest a strong association of HMI with SK therapy and with acute mechanical complications.
L-carnitine moderately improves the exercise tolerance in chronic stable angina.
(2000-11-20) Iyer, R N; Khan, A A; Gupta, A; Vajifdar, B U; Lokhandwala, Y Y
OBJECTIVES: To study the safety and efficacy (with reference to exercise ECG testing) of oral L-carnitine in chronic stable angina. METHODS: Forty-seven patients, 30 men and 17 women, aged 56 +/- 8 years, were randomized to receive L-carnitine (n = 28) or placebo (n = 19) in the dose of 2 g/day for 3 months. The adjuvant treatment was not changed during the study. Patients were evaluated by computerized stress test (CST) done at the beginning and end of the trial. The parameters assessed were exercise duration, time to onset of ST changes, total ST score at peak exercise, rate-pressure product at peak exercise, and time needed for the ST changes to recover to baseline. RESULTS: The two groups were comparable at the beginning of the study. There was no change in the CST parameters in the placebo group at the end of 3 months. In the L-carnitine group there was a statistically significant improvement in the exercise duration from 7.8 +/- 2.2 min to 8.6 +/- 1.8 min (p = 0.006) and in the time needed for the ST changes to revert to baseline from 7.2 +/- 3.9 min to 5.7 +/- 3.8 min (p = 0.019). No change was noted in the time to onset for ST depression, ST score and double product. There were no systemic adverse effects or coronary events in either group. CONCLUSION: Oral L-carnitine is safe and moderately improves the duration of exercise and time to recovery of ST changes in patients with chronic stable angina.
Long term results of percutaneous transluminal valvuloplasty in patients with valvular aortic stenosis.
(1992-03-01) Kale, P A; Sathe, S V; Rajani, R M; Lokhandwala, Y Y; Silva, S D; Mehan, V K; Kaneria, V K; Kulkarni, H L; Dalvi, B V
The results of percutaneous balloon aortic valvuloplasty (PBAV) in 62 consecutive patients with valvular aortic stenosis are reported. The age of the patients ranged from 11 months to 72 years (mean 28 +/- 12 years). Hemodynamically successful dilatation was achieved in 58 out of 62 patients. This was associated with marked clinical improvement in these patients. The left ventricular aortic peak to peak gradient decreased from 96.67 +/- 38.4 to 28.14 +/- 26.5mmHg (p < 0.01). There were no deaths during the procedure. Only one patient died in the hospital during the same admission. There was an increase in aortic regurgitation (AR) by at least one grade in 25 (40.3%) patients. Femoral arterial thrombosis was seen in 9/62 patients, 5 of them requiring surgical intervention. Follow up was available in 28 (45.1%) patients over a period of 2-15 months (mean 9 +/- 3 months). Two patients died during the follow up period. Doppler evaluation of gradients was done in all 28 patients with 15 consenting to undergo repeat cardiac catheterisation. Although hemodynamically the restenosis rate was 35.7% (10/28), only 2 of these patients showed symptomatic deterioration. The success of dilatation and restenosis rate were independent of the etiology of aortic stenosis, presence of calcification and the number of balloons used. This study demonstrates that PBAV is feasible in valvular aortic stenosis at low risk and is able to produce significant clinical and hemodynamic improvement in most cases with a restenosis rate of 35.7% at a follow up period of 9 +/- 3 months.
Neurally-mediated syncope: an overview and approach.
(2003-08-04) Shah, J S; Gupta, A K; Lokhandwala, Y Y
Newer antiarrhythmic drugs.
(2001-05-23) Gupta, A K; Maheshwari, A; Thakur, R K; Lokhandwala, Y Y
Pictorial CME. A break in the lead density below the clavicle suggestive of fractured lead.
(2002-07-20) Toal, S C; Sinhal, A R; Lokhandwala, Y Y

Browsing by Author "Lokhandwala, Y Y"

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