Browsing by Author "Kumar, T R"
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Item Comparative study of omeprazole and famotidine in the treatment of duodenal ulcer.(1992-04-01) Kumar, T R; Naidu, M U; Shobha, J C; Reddy, D N; Subhash, S; Chaubal, C; Prasad, R; Babu, SIn a double blind, multicenter, parallel group clinical trial in patients with symptomatic duodenal ulcers, 129 patients were randomized to receive either omeprazole 20 mg once daily (n = 65) or famotidine 40 mg once daily (n = 64) for 2 weeks, and if the ulcers were not healed, for a total of 4 weeks. Seventy four percent of these receiving omeprazole had healed ulcers after 2 weeks compared with 34.3% of those receiving famotidine (p < 0.001). At 4 weeks, the respective figures were 97.3% and 77.6% (p < 0.001). After 2 weeks of treatment, only 11.1% and 29.8% of omeprazole and famotidine treated patients respectively had day time pain (p < 0.02). Diary cards (successfully completed by 2/3rd of patients) showed that omeprazole treated patients required smaller amounts of antacids (p = ns). Over the first two weeks, ulcer healing rate was similar in smokers and non- smokers. No significant side effects were reported in either group. Omeprazole 20 mg/day provides more rapid relief of symptoms and heals a greater proportion of duodenal ulcers at 2 and 4 weeks than famotidine 40 mg/day.Item Early beneficial effects of low dose oral methotrexate in rheumatoid arthritis.(1990-05-01) Rao, U R; Thopu, A R; Naidu, M U; Kumar, T RThe effect of low dose methotrexate pulse therapy was studied in 21 patients with active rheumatoid arthritis. Three doses of oral methotrexate 2.5 mg at 12 hourly intervals weekly was administered to all the patients. Patients were followed up for clinical, radiological and serological evaluation. Significant reduction in the number of painful and swollen joints, decrease in the duration of morning stiffness, fall in the erythrocyte sedimentation rate, and improvement in global assessment were seen in 15 patients (71.4%) by the end of 16 weeks. Five patients (23.8%) complained of minor gastric discomfort. None of the patients discontinued the treatment because of any side effect.Item Evaluation of efficacy and safety of losartan potassium in the treatment of mild to moderate hypertension as compared to enalapril maleate.(2000-05-29) Shobha, J C; Kumar, T R; Raju, B S; Kamath, S; Rao, M; Harwal,; Babu, A; Bhaduri, JAIM: To study the effect of losartan potassium in the treatment of mild to moderate hypertension and to compare its efficacy and adverse effect profile with enalaparil maleate. MATERIAL AND METHODS: One hundred and forty five patients with mild to moderate essential hypertension were enrolled in this randomized, double blind, controlled, parallel and multicentric study. Seventy two patients received losartan potassium 50 mg and seventy three received enalapril maleate 5 mg. RESULTS: Losartan potassium reduced the DBP to < 90 mm Hg in 59% of the patients at the end of 8 weeks compared to 45% in the enalapril maleate group. DBP was reduced by 10 or > than 10 mm Hg in 89% of the patients with losartan as compared to the baseline whereas it was 80% in the enalapril group. Percentage of side effects seen in losartan and enalapril groups were 12 and 22 respectively. CONCLUSION: Losartan potassium is an efficacious antihypertensive agent in mild to moderate hypertension. It also has fewer side effects when compared to enalapril maleate.Item Inhalation steroids, some aspects and ways in the management of asthma.(1994-07-01) Majumdar, S P; Kumar, T RInhalation of steroid is important in the management of asthma and at present various steroids are available for inhalation. Aerosol treatment with steroids is most effective if used in several doses throughout the day. In moderately severe asthma it may be ineffective until airways are cleared by adequate oral doses. There are several methods of inhalation eg, metered dose inhalation, dry powder inhalation and nebulisation. The pressurised metered dose inhaler is widely used for its main advantage of compactness, convenience and readiness for use. Powdered inhalers are considered safe especially for use in children. No co-ordination is required by the patient in cases of administration by nebulisation. Inhaled route is preferred to systemic route because of its better therapeutic index ie, fewer side-effects for equivalent clinical effects. But poor inhalation technique is the reason for failure of aerosol steroids.Item Strategies for purification of four reproductive hormones from the same batch of buffalo (Bubalus bubalis) pituitaries.(1994-02-01) Muralidhar, K; Kumar, T R; Chadha, N; Khurana, S; Khanna, T; Sharma, H PThe occurrence of different reproductive hormones like LH, FSH, TSH and prolactin, in different side fractions obtained during the extraction of buffalo pituitary glands either by the procedure of Papkoff et al. [Arch Biochem Biophys, 111 (1965) 431] or by that of Ellis [Endocrinology, 69 (1961) 554], was examined with the aid of antisera to respective heterologous hormones as well as bio-assays. Thus in the procedure of Papkoff et al., the SP-Sephadex fractions could be taken for purification of LH and TSH, while the acid pellet yielded prolactin. Further it was shown that 50% (NH4)2SO4 could be directly size fractionated and following cation exchange chromatography yields LH and TSH. FSH could be purified from 80% ammonium sulphate pellet. In another protocol of Ellis, differential extraction and chromatographic separation yielded all the four reproductive hormones. Some of the physico-chemical and immunobiological characteristics of these hormones are described.