Browsing by Author "Kumar, M Senthil"
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Item Development of quality control parameters for the standardization of Leaves and bark of Sida acuta Burm.f.(2014-10) Semwal, Alok; Kumar, M SenthilSidha acuta Burm. f belonging to family Malvaceae is a terrestrial, erect shrub which is up to 155 cm tall. The plant is native to Mexico, Central America and Himalayan region of India but has spread throughout the tropics and subtropics. Sida acuta Burm. f is widely distributed in pantropical areas and is widely used as traditional medicine in many cases. Among illnesses the plant is may be used alone or in combinations with other plants to cure fever, skin diseases, snake bites, Hemorrhoids, impotency and for boils and eye cataracts. Although the plant has been screened and suggested for various therapeutic activities its photocomposition remained unrevealed because of very restricted amount of research work carried out. Thus it was thought worthwhile to explore this endangered plant on the basis of various standardization parameters. The present research work deals with the collection, identification, extraction, pharmacognosical and phytochemical investigation of Leaves of Sidha acuta Burm. f.Item Morphological and molecular characterization of Aedes aegypti variant collected from Tamil Nadu, India(Wolters Kluwer – Medknow, 2022-01) Kumar, Nirmal P; Kalimuthu, M; Kumar, M Senthil; Govindrajan, R; Venkatesh, A; Paramasivan, R; Kumar, Ashwani; Gupta, BhavnaBackground & objectives: Accurate mosquito species identification is the basis of entomological surveys and effective vector control. Mosquito identification is either done morphologically using diagnostic features mentioned in taxonomic keys or by molecular methods using cytochrome oxidase subunit 1 (coxI) and Internal transcribed spacer 2 (ITS2). Methods: We performed a larval survey for Aedes mosquitoes from eight different geographical regions in Tamil Nadu, India. The mosquitoes collected during the survey were characterized using both morphological and molecular markers. Results: During an entomological survey from eight different geographical regions in Southern India, a morphological variety named Aedes aegypti var. luciensis was observed. The variant mosquitoes were characterized using both morphological and molecular markers. The variant mosquitoes differed only in the dark scaling of 5th segment of hind-tarsi. Around one third to two third of the 5th segment in variant mosquitoes was dark which has been described as white in identification keys. No other significant difference was observed in adults or immature stages. The variation was heritable and coexisting in the field with the type form mosquitoes. Comparison of the genetic profile of coxI and ITS2 were similar in variant and the type form indicating both of them to be conspecific. Interpretation & conclusion: The morphological variant mosquitoes were found genetically similar to the Ae. aegypti type form. However, considering its high prevalence and coexistence with Ae. aegypti type form in different geographical regions, detailed studies on bionomics, ecology, genetics, behavior as well as its plausible role in disease transmission are warranted.Item Pure neural leprosy presenting with multiple nerve abscesses.(2004-10-27) Laxmisha, C; Thappa, D M; Kumar, M Senthil; Joseph, L C; Jayanthi, SA 22-year-old male student presented to us with patchy sensory loss over the dorsum of right foot of 6 months' duration and swelling over the left index finger of 2 months' duration. Subsequently, a week later, he developed a painful swelling over the left forehead and right leg. On examination, tender soft, fluctuant subcutaneous saccular swellings were seen varying in size from 2x2 cm to 5x5 cm over the left supratrochlear, left radial cutaneous nerve, left digital nerve, right superficial peroneal nerve and left saphenous nerve. The nerves were tender and thickened above and below these cold swellings (cold nerve abscesses). Nerve biopsy of the left radial cutaneous nerve showed granulomatous infiltrate of epithelioid cells, lymphocytes and caseation necrosis of nerve. No bacilli were demonstrated with acid-fast stain. On the basis of the above findings, a diagnosis of pure neuritic leprosy (BT spectrum) in type 1 lepra reaction with multiple nerve abscesses was made. We present this case of pure neuritic leprosy exhibiting multiple nerve abscesses, for its rarity.