Browsing by Author "Kumar, M S"
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Item Angioplasty of membranous obstruction of inferior vena cava.(2001-09-12) Kannan, R; Ramprakash, B; Kumar, M S; Balachander, J; Sethuraman, K RMembranous obstruction of vena cava (MOVC) is a common cause of hepatic venous outflow obstruction. Surgical procedures utilized to relieve symptoms carry a high morbidity and mortality. A patient who presented with gradual onset ascites and dilated, tortuous veins over the anterior abdominal wall and the back was found to have MOVC by inferior vena cavogram. Balloon dilatation of the obstruction was done successfully through a transvenous approach. Following this, the patient improved remarkably. The procedure is safe, effective and easy to perform. This balloon angioplasty provides alternative method for treatment of membranous obstruction of vena cava.Item An audit of febrile neutropenia cases from a rural cancer center in India.(2014-10) Patil, V M; Chakarborty, S; Kumar, M S; Geetha, M; Dev, S; Samuel, S; Ahmed, G; Nayanar, S K; Vineetha, R; Nair, C KBACKGROUND: Data of febrile neutropenia (FN) from rural cancer centers is sparse. We did a audit of outcome of patients with FN in the period of March 2013‑August 2013. The aim was to help us to develop rational antibiotic usage policies. MATERIALS AND METHODS: Retrospective analysis of all consecutive patients presenting with FN. Data regarding demographic profile, tumor type, intent of treatment, chemotherapy regimen, blood culture susceptibility details, use of antibiotics, response to antibiotics and complications of FN were noted. SPSS (Statistical Product and Service Solutions) 16 was used for analysis. RESULTS: 67 patients had FN and there were 91 episodes. The median day of presentation with FN after start of chemotherapy was 10 days. The nadir absolute neutrophil count was 161.5 and nadir platelet count 1,00,000. The median multinational association for supportive care in cancer (MASCC) Score was 24. In accordance with MASCC there were 27 high risk FN and 64 low risk FN episodes. On multivariate analysis using logistic regression MASCC score strata was the only significant variable that predicted failure to 1st line antibiotics (P = 0.03) and mortality (P = 0.01). Nine patients (9.9%) had positive isolates on blood cultures. The blood culture isolates were predominantly Gram negative (66.7%). CONCLUSION: The importance of developing local guidelines for rational antibiotic usage is highlighted.Item The ethical practice of medicine in India.(1986-12-01) Panjwani, D D; Kumar, M S; White, A G; Abouna, G MItem Immunophenotype alteration in acute lymphoblastic leukaemia at relapse.(1987-10-01) Athanikar, N; Advani, S H; Gopal, R; Nair, C N; Saikia, T K; Nadkarni, K S; Kurkure, P A; Pai, V R; Pai, S K; Kumar, M SItem Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds.(2009-04) Mahadeswaraswamy, Y H; Devaraja, S; Kumar, M S; Goutham, Y N J; Kemparaju, KAlthough anti-venom therapy is available for the treatment of fatal bite by snakes, it offers less or no protection against the local effects such as dermo- and myonecrosis, edema, hemorrhage and inflammation at the bitten region. The viper species are known for their violent local effects and such effects have been commonly treated with plant extracts without any scientific validation in rural India. In this investigation, the methanolic extract of grapes (Vitis vinifera L.) seed was studied against the Indian Daboia/Vipera russelli venom-induced local effects. The extract abolished the proteolytic and hyaluronidase activities and also efficiently neutralized the hemorrhage, edema-inducing and myonecrotic properties of the venom. In addition, the extract also inhibited partially the pro-coagulant activity of the venom and abolished the degradation of Aα and Bβ chains of human fibrinogen. Thus, the extract possesses potent anti-snake venom property, especially against the local effects of viper bites.Item Occurrence of extended spectrum beta-lactamases among Enterobacteriaceae spp. isolated at a tertiary care institute.(2006-07-17) Kumar, M S; Lakshmi, V; Rajagopalan, RIncreasing resistance to third generation cephalosporins has become a cause for concern especially among Enterobacteriaceae that cause nosocomial infections. The prevalence of extended spectrum beta-lactamases (ESBLs) among members of Enterobacteriaceae constitutes a serious threat to current beta-lactam therapy leading to treatment failure and consequent escalation of costs. A detailed study was initiated to identify the occurrence of ESBLs among the Enterobacteriaceae isolates at a tertiary care hospital using the double disk potentiation technique. Antibiogram profiles were determined to commonly used antibiotics and confirmation of ESBLs production was carried out by the disk diffusion assay using ceftazidime and cefotaxime in the presence and absence of clavulanic acid. Our results indicate that the majority of ESBLs were expressed in Escherichia coli.Item Omphalopagus--successful separation of conjoined twins in the newborn period.(1989-09-01) Prasad, C N; Haran, R H; Prasad, G R; Kumar, M S; Prabhakar, VItem Production & characterization of PL 1/54, a monoclonal antibody reactive with a functionally important platelet-associated antigen.(1988-09-01) Das Gupta, A; Dhond, S R; Kumar, M S; Shinde, S CItem Spontaneous pneumothorax complicating rheumatoid lung disease.(1989-10-01) Thippanna, G; Prasad, S V; Kumar, M SThis case report describes the pleuro-pulmonary involvement in a young patient with rheumatoid arthritis (RA) of one and half year duration. The early involvement of lung interstitium in a 27-year-old male and development of pneumothorax were the unusual features. The various aspects of rheumatoid lung disease (RLD) and its clinical significance were briefly discussed.Item Unusual presentation of Norrie's disease with hypomagnesemia.(1998-08-27) Kumar, M S; Shenoi, A; Mukta Jain, M; Ashok, J; Chidananda, S C; Sameera, P; Maseeuddin, S