Browsing by Author "Khin Aye Than"
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Item Chemical composition of home-based fluids commonly used in Myanmar(1993-12-01) Win Myint; Hla Pe; Po Aung, Saw; Win Kyi; Khin Aye Than; Mya BwinRehydration measure should be instituted as early as possible when lifethreatening dehydration state due to diarrhoea or severe fever is suspected or detected. Home-based fluids are usually given under such circumstance and thus chemical compositions of syrups (m=9), soft drinks (n=5), fresh fruit juices (n=3) and plant decoctions (n=7) were analysed by using published methods and atomic absorption spectrophotometer. High concentrations of total sugars (8.67 to 34.87 g/100ml) and free reducing sugars, mainly as glucose and fructose (1.97 to 21.49) g/ 100ml) were detected in syrups and soft drinds. Potassium was found to be rich in plant decoctions (34.08 to 273.10 mg/100ml) and sodium in soups (140.0 to 475.0 mg/100ml). Soft drinks were found to be acidic (pH = 2.76 to 3.63) whereas soups and plant decoctions have pH values 5.29 to 8.91. Colours used in syrups and soft drinks were found to be permitted dyes.Item Clinical trial of antidiabetic traditional medicine formulation (TMF) No. 32(1994-04-01) Thaw Zin; Nwe Nwe Win; Win Myint; Khin Aye Than; Tin Mi Mi Naing; Aung Naing; Kyaw Sein; Maung Maung WintClinical trial to determine the therapeutic efficacy of a traditional antidiabetic drug, TMF-32, was carried out on six Type II NIDDM patients who were admitted to the Traditional Medicine Hospital, Yangon. All patients, 3 males and 3 females, had a fasting blood glucose level of more than 150 mg percent (205.2 + 35.6) and a 2 hour post-prandial blood glucose level of more than 200 mg percent (323.0 + 62.09) and were clinically free from complications of diabetes. The study was a complete cross-over design, using tolbutamide as a control and was conducted under strict diabetic diet wupplying approximately 2500 kcals per day. Hypoglycaemic efficacy calculated from oral glucose tolerance test (OGTT) curves indicated that TMF-32, at doses of 2G and 3G, significantly reduces the blood glucose levels in these patients (p < 0.01 in both doses). The maximum hypoglycaemic effect was seen at approximately 2 hours after dosing and the duration of action lasted only up to 6 hours. Construction of log. dose-response curves showed TMF-32 of having a hypoglycaemic potency of 73 percent of tolbutamide but frequent side effects and cost of drug give rise to contradicting questions on whether it may be useful as a standard traditional antidiabetic drug.