Browsing by Author "Khanna, S K"

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    Absorption & metabolic disposition of azo dye metanil yellow in rats.
    (1982-01-01) Raza, H; Khanna, S K; Singh, G B; Murti, C R
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    Adulterants in our daily eatables and their toxicity.
    (1975-01-01) Khanna, S K; Singh, G B; Singh, S B
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    Anaesthetic management of patients undergoing surgery for tachyarrhythmias. Initial experience with 16 patients.
    (1997-03-01) Tempe, D K; Joshi, N; Mehta, N; Khanna, S K; Banerjee, A; Tyagi, S
    Sixteen patients suffering from various cardiac arrhythmias were treated surgically. Intraoperative computerised electrophysiologic mapping was used in 14. Thirteen patients were suffering from Wolff-Parkinson-White syndrome. They underwent surgical division or cryoablation of accessory pathways. Two patients who had rheumatic mitral stenosis with left atrial clot underwent "Maze III" procedure with open mitral commissurotomy and clot removal. One patient with paroxysmal refractory ventricular tachycardia and a left ventricular aneurysm had an aneurysmectomy with subendocardial resection of the arrhythmic focus. All antiarrhythmic medications were discontinued preoperatively. Morphine was the principal anaesthetic agent, supplemented with halothane. Muscle relaxation was provided with pancuronium bromide. The various problems encountered included hypotension and arrhythmia during placement of epicardial band array for mapping (4 patients), ventricular tachycardia during internal jugular vein cannulation (1 patient) and continuance of delta wave after cryoablation in 2 patients. Halothane may have interfered with electrophysiologic mapping and accurate localization of accessory pathway leading to persistence of delta wave. The choice of anaesthetic agents should be guided by the electrophysiologic effects and potential influence of these agents on the accessory pathways.
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    Anhidrotic ectodermal dysplasia.
    (1968-06-01) Bhogaonkar, A; Khanna, S K
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    Azo reductase activity of microbial population from gastrointestinal tract segments of various animals species.
    (1998-01-16) Singh, S; Das, M; Khanna, S K
    Azo reductase activity of microbial population of stomach, small intestine, caecum and large intestine of different animals was investigated. There was low activity in stomach flora of wistar rat and 3 strains of mice. Flora of proximal portion of small intestine in different species revealed that carnivorous animals exhibited maximum activity followed by grazing animals. Maximum activity in middle portion of small intestine was noted in dog (98.2%), while minimum was observed in guinea pig (23.3%). Majority of test animals revealed maximum floral azo reductase activity (58-98%) in caecum. Activity in proximal portion of large intestine was highest in dog while pigeon and guinea pig had least activity (23.3-27.1%). Appreciable microbial activity in distal end of large intestine was noted in sheep and goat. In all the 15 animal species investigated caecum showed maximum activity followed by pre and post caecal segments while stomach possessed the least. The results suggest that inter-species differences exist in microbial reductive activity which may be due to variation in composition and distribution of GI tract microflora and thus can influence toxicological implication of various dyes.
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    Bio-metabolic disposition of metanil yellow, orange II and their blend by caecal microflora of rats.
    (1995-07-01) Singh, S; Das, M; Khanna, S K
    Caecal microflora were employed to study the degradation pattern, with time course of Metanil yellow and Orange II-two extensively used non-permitted food colours. Metanil yellow and Orange II showed the respective Degradation Index 50 (DI 50) values of 369 and 288 min. However, the blend of Metanil yellow and Orange II (1:1) resulted in the D1 50.value of 288 min. Metanil yellow, Orange II and their blend were resolved into respective metabolites in different solvent systems.
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    Blood conservation in valve surgery.
    (1994-03-01) Tempe, D; Cooper, A; Khanna, S K; Satsangi, D K; Tomar, A S; Lall, N G; Gupta, B K; Mishra, R C; Nigam, M
    Blood utilization in 40 patients undergoing elective valve surgery was prospectively studied. The patients had valvular lesions of rheumatic origin with a mean age of 29.1 years and a mean preoperative hematocrit of 35.23 +/- 4.16. Blood was removed from all patients after induction of anesthesia and reinfused after bypass (mean 365.12 +/- 66.96 ml). Membrane oxygenator was used in all the patients. All discard suction was routed through a regionally heparinised collecting and processing system, and the resulting red cell concentrate was transfused. At the conclusion of bypass, all blood remaining in the pump oxygenator was also processed by cell saver and used for subsequent reinfusion. Normovolemic anemia was accepted in hemodynamically stable patients. Thirty two patients (80%) received no bank blood or blood products during their entire hospital course. A total of twelve units of whole blood was transfused into eight patients.
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    Calcified mobile papillary fibroelastoma of the tricuspid valve: a case report.
    (1987-05-01) Mohan, J C; Goel, P K; Gambhir, D S; Khanna, S K; Arora, R
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    Cannulation of the internal jugular vein in patients undergoing open heart surgery.
    (1992-03-01) Tempe, D; Tomar, A S; Bhise, M; Khanna, S K
    A total of 476 internal jugular vein cannulations performed between June 1990 to August 1991 were prospectively evaluated. The patients' age ranged between ten days to 61 years. We achieved a high success rate of cannulation (97.9%). We describe the use of two single lumen catheters inserted through right internal jugular vein as an alternative to the popular multilumen catheters. We also suggest that low approach should be tried more often in children, if the central approach fails.
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    Cardiac myxomas--a clinicopathological study.
    (1983-11-01) Beohr, P C; Malhotra, V; Khalilullah, M; Khanna, S K; Narayanan, P S; Gupta, M P; Rani, S
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    Cerebrospinal fluid lactic dehydrogenase activity in various neurological disorders.
    (1976-01-01) Khanna, S K; Gupta, D K; Gupta, B K; Khanna, P
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    Choledocho-duodenal fistula due to tuberculosis.
    (1989-10-01) Chaudhary, A; Bhan, A; Malik, N; Dilawari, J B; Khanna, S K
    An unusual case of caseating nodal tuberculosis causing a choledocho-duodenal fistula is reported. Anti-tubercular treatment led to closure of the fistula.
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    Colour Doppler echocardiographic quantification of prosthetic aortic valve regurgitation in patients with normally functioning Bjork-Shiley prostheses.
    (1992-05-01) Mohan, J C; Agrawal, R; Calton, R; Arora, R; Gupta, B K; Nigam, M; Satsangi, D K; Khanna, S K; Khalilullah, M
    Colour Doppler echocardiographic studies were performed in 46 patients (age range 16-35 years, mean 26 +/- 8; male 31, female 15) with normally functioning Bjork-Shiley prostheses in aortic position to estimate transprosthetic regurgitation. Regurgitant jet length and height were measured and assessed in multiple views. All patients showed prosthetic regurgitation of varying degree. Regurgitant jets were central in all but 3 (6.5%) patients. Single jets were seen in 28 (61%) and double jets in 18 (39%). Jet height in parasternal long axis view ranged from 0.4 to 1.2 cm (mean 0.7 +/- 0.4 cm) and jet height to left ventricular outflow tract diameter ratio was 0.22 to 0.48 (mean 0.38 +/- 0.13). Prosthetic regurgitation was < or = 2/4 grades in 42 (91%) patients, and combined height of double jets (n = 18) was less than that of the single jets (n = 28) (0.5 +/- 0.3 cm vs 0.8 +/- 0.4 cm, p < 0.05). In conclusion, colour Doppler examination frequently detects prosthetic regurgitation in patients with aortic Bjork-Shiley prostheses; regurgitation is grade 2/4 or less in most of the patients, is overestimated in patients with a single jet and weakly correlates with prosthesis size.
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    Comparative azo reductase activity of red azo dyes through caecal and hepatic microsomal fraction in rats.
    (1997-09-25) Singh, S; Das, M; Khanna, S K
    In order to study the rate of formation of toxic aromatic amines, anaerobic reduction of four red azo dyes viz. amaranth, carmoisine, fast Red E and ponceau 4R was investigated by incubating caecal content and hepatic microsomal fraction of rats with 37.5 microM concentration of dyes in sodium phosphate buffer pH 7.4 using NADPH generating system, glucose oxidase system and nitrogen as the gaseous phase. Caecal suspension exhibited higher azo reductase activity than that of hepatic microsomal fraction using any of the 4 azo dyes. Caecal microbes showed maximal azo reductase activity when ponceau 4R was used as a substrate followed by fast Red E and carmoisine, while with amaranth the activity was minimum. Similarly ponceau 4 R exhibited maximum hepatic microsomal azo reductase activity followed by fast Red E and carmoisine whereas, amaranth had minimum activity. Caecal flora possessed almost 17 fold higher degradative capability of ponceau 4 R and fast Red E colourants than the hepatic microsomal fraction. The higher reductive ability through caecal flora for ponceau 4R and fast Red E signifies the formation of more aromatic amines which may be re-absorbed through the intestine to be either eliminated through urine as conjugates or retained in the target tissues to elicit toxic effects.
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    Control of postoperative vomiting by thiethylperazine.
    (1965-12-01) Khanna, S K; Anand, S S; Saini, V K
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    Control of tachycardia and hypertension following coronary artery bypass graft surgery: efficacy and haemodynamic effects of esmolol.
    (1999-05-07) Tempe, D K; Mulchandani, P; Tandon, M S; Mehta, N; Tomar, A S; Banerjee, A; Khanna, S K
    Hypertension following coronary artery bypass grafting is not uncommon, especially in patients having good left ventricular function. It is often accompanied by tachycardia. The purpose of this study is to determine the efficacy of esmolol in the treatment of tachycardia and hypertension immediately following cardiopulmonary bypass and to study other haemodynamic effects of esmolol. Thirty patients undergoing elective [corrected] coronary artery bypass grafting were included in this prospective study. Morphine-based anaesthetic technique along-with standard bypass techniques were used in all the patients. The study was performed in the operating room about 30-45 minutes after the termination of cardiopulmonary bypass. Patients having a heart rate of more than 90 bpm and systolic blood pressure of more than 130 mm Hg without any inotropic support were included and randomly assigned to esmolol or control group. Esmolol was administered in a bolus dose of 500 micrograms/kg followed by infusion of upto 100 micrograms/kg/min. The patients in the control group were administered comparable volumes of normal saline. Baseline haemodynamic measurements were obtained just before the administration of esmolol or normal saline and were repeated after 5, 10, 15, 30 and 45 min. The baseline measurement in both the groups showed that patients were maintaining a state of hyperdynamic circulation with high systolic blood pressure (esmolol group 148 +/- 15 mm Hg, control group 140 +/- 8 mm Hg; p = NS), heart rate (esmolol group 128 +/- 17 bpm, control group 127 +/- 17 bpm; p = NS) and cardiac index (esmolol group 3.1 +/- 1 L/min/m2, control group 3.3 +/- 0.5 L/min/m2; p = NS). Esmolol decreased systolic blood pressure (p < 0.001), heart rate (p < 0.01) and cardiac index (p < 0.05) at five minutes. These changes persisted throughout the study period. The left ventricular stroke work index decreased at five minutes (p < 0.05) and remained so till 30 minutes. The maximum fall in heart rate (15%) and systolic blood pressure (16%) was observed at 45 minutes. There were no haemodynamic changes in the control group except that cardiac index, stroke volume and left ventricular stroke work index increased at five minutes. We conclude that esmolol lowers the indices of cardiovascular work in patients who demonstrated hyperdynamic circulation. This was achieved by decreasing the heart rate and systolic blood pressure which was accompanied by decrease in cardiac index and left ventricular stroke work index.
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    Coronary angioplasty of 'complex lesions' in patients with unstable angina.
    (1989-07-01) Gambhir, D S; Nair, M; Prasad, R; Sethi, K K; Khanna, S K; Khalilullah, M
    Out of 55 patients subjected to coronary angioplasty over the past 12 months, there were 33 (60%) who had unstable angina. Amongst these, 22 patients had coronary lesions classified as 'complex' on coronary angiography. These included tandem lesions, branch stenoses, distal lesions, total occlusions, vein graft stenoses, lesions with ulceration and intraluminal clot and associated with valvular lesions. We describe our experience of coronary angioplasty in these 22 patients of unstable angina having 'complex lesions'. All were males with a mean age of 48.7 +/- 13 years. Fourteen patients had single vessel and 8 multivessel disease. A total of 35 lesions were subjected to dilatation. The angiographic primary success was achieved in 85.7% of the lesions attempted. Except total occlusions and very distal lesions, all other types of 'complex lesions' could be dilated with a success rate of greater than 75%. There were 4 (11.4%) failures because of inability to cross the lesion with the guidewire or balloon catheter. One patient developed non-Q wave inferior wall infarction. There were no deaths. We conclude that coronary angioplasty of various types of 'complex lesions' can be performed with a good primary success and negligible complications in our setting.
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    Coronary sinus rupture secondary to retrograde cardioplegia.
    (1998-09-03) Agrawal, D; Lohchab, S S; Mehta, N; Bohra, P; Bhargava, M; Bhardwaj, S; Tempe, D; Khanna, S K
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    Cystosarcoma phyllodes. A study of 15 cases.
    (1969-09-01) Chander, J; Garg, L D; Khanna, S K