Browsing by Author "Khan, Ibrahim"
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Item In-vitro Anticancer and In silico Assessment of Oxalis corniculata Against Colorectal Cancer (HCT 116) Cell line(MRI Publication Pvt. Ltd., 2024-06) Ansari, Saif MS; Prakash, Veeru; A, Sushma; Rao, K. P.; Ahmed, Danish; Khan, Ibrahim; Lall, Alok M.Colorectal cancer is the third most frequently diagnosed cancer in both genders and the fourth foremost cause in respect to cancer-associated mortality. The metastasis mechanism of colorectal cancer shows that it gradually developed in the form of polyps under granular cells in the large intestine, which damages blood and lymph vessels. At present, chemotherapy and surgery are the major clinical approaches in treatment. Therefore, developing novel and effective drugs are requiring use of natural derivative compounds, a potent and significant effect in restricting the progression of colorectal cancer (CRC). The present research investigates the in vitro anticancer properties of various extracts of plant Oxalis corniculata counter cell viability of CRC cell line (HCT116) using an MTT assay. In silico docking studies of hexadecanoic acid were performed with cytochrome P450CYP17A1 protein (3RUK) to predict potential inhibitors and druglikeness as potential CRC inhibitors using ADME profiling adhered to five rule of Lipinski. The finding indicated the extracts of the Oxalis corniculata have anticancer and anti-proliferative activity. The cell cytotoxic observed against chloroform extract exhibited the highest inhibition against the HCT116 cell line, following ethanol and aqueous extract. The determined IC50 values for the ethanol, aqueous, and chloroform extracts were 53.94±1.29 µg/ml, 61.85±0.43 µg/ml, and 47.34±1.24 µg/ml, respectively The in silico molecular docking result shows that n-hexadecanoic acid compound was found to be effective against 3RUK protein associated with CRC. Therefore, the finding suggests Oxalis corniculata plants could be used to formulate potential therapeutic drugs for the development of anticancer agents.Item Knowledge and attitudes towards dietary patterns and lifestyle during COVID-19 pandemic in Bangladesh: an online based cross-sectional study(Medip Academy, 2023-03) Uddin, Ielias; Rokon, M. A.; Sultana, Sabiha; Jahin, Anika; Mursalin; Khan, Ibrahim; Setu, S. S.; Rahman, Mahnaz; Hasan, M. Sahedul; Yeasmin, Empa; Rini, A. H.Background: COVID-19 outbreak being the only pandemic of 21st century, that affected globally, has left us with some realization that elucidate the advancement in science and medicine is not enough to live a healthy life for the generation of modern era, if lifestyle and habitual factors are not controlled or maintained in proper way. In this study we aimed to find out people’s knowledge and attitudes about dietary patterns and lifestyle during COVID-19. Methods: An online based questionnaire was designed to collect the data based on the age limit of 15 to 60+ years. The survey was focused on both the affected and exposed individuals (n=853). The data was collected under three main sections containing questions about nutritional knowledge, preventive measures adapted by the respondents, lifestyle practices and their concerns. Results: The outcome of the study reveals, significant association between gender of the study and their food consumption diversity (p=0.026<0.05), participants awareness about COVID-19 depends on their education level. Study also displayed the infection rate, acceptance of vaccination, change of food habit and weight gain tendency depends on the age of the individual, showing statistical significance. Conclusions: The outcome of the study acquaints that proper balance between knowledge and practice, is the most important attitude, which can build prevention against any new public health threat like COVID-19 outbreak.