Browsing by Author "Kaur, S"

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    Abdominal cocoon: an unusual intestinal obstruction (a case report).
    (1984-01-01) Ahmed, M N; Kaur, S; Zargar, H U
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    Acid fast bacilli in lymph node aspirate and smears from ear lobules and fingers in long treated patients.
    (1984-01-01) Kumar, B; Kaur, S; Gupta, S K; Rajwanshi, A; Darshan, H
    Skin slit smears from fingers and ear lobules and lymph node aspiration smears stained with Ziehl-Neelsen stain were studied in 43 patients of LL or BL disease. All the patients had taken dapsone monotherapy for 3-7 years. None of the patients had clinical evidence of dapsone resistance. Small number of bacilli were detected in 16 patients. Lymph node aspirate was positive in 5 cases, whereas ear lobule and fingers yielded bacilli in 12 and 13 cases respectively. It is recommended that in addition to the traditional ear lobe it is imperative to study other sites as well. Study from fingers is recommended for the sake of simplicity. Where facilities are available sampling of the lymph node may also be attempted to advantage.
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    Acquired hemostatic defects during L-asparaginase therapy.
    (1986-07-01) Marwaha, N; Marwaha, R K; Sarode, R; Kaur, S; Ghosh, K; Garewal, G; Mohanty, D
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    ADCC function in Mycobacterium leprae inoculated normal and immunosuppressed mice.
    (1986-07-01) Ganguly, N K; Vaishnavi, C; Kumar, B; Kaur, S
    Normal and immunosuppressed mice were inoculated with Mycobacterium leprae obtained from untreated lepromatous patients. Besides monitoring the AFB counts in the footpads at 3,6 and 9 months post inoculation, antibody dependent cellular cytotoxicity (ADCC) function was studied. The ADCC function seen to be largely unaltered in the M. leprae infected animals, comparable to the observation made in human leprosy.
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    Adenosine triphosphate content of Mycobacterium leprae by percoll buoyant density centrifugation.
    (1992-05-01) Sharma, V K; Kaur, S; Kaur, I; Thakur, M; Vaishnavi, C; Kohli, M; Ganguly, N K
    Thirty nine untreated patients of bacilliferous leprosy with a mean bacteriological index of 4.8 and morphological index of 1.3% formed the study group. Adenosine triphosphate assay was carried out by (i) enzyme treatment method in 18 patients and (ii) percoll buoyant density gradient method in 21 patients. ATP content obtained by percoll buoyant density gradient method was significantly higher than that obtained by enzyme treatment method. Percoll buoyant density centrifugation for purification and isolation of bacilli from human leproma is simplier, quicker and can serve as an alternate method of enzyme treatment.
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    Adrenal cortical reserve in leprosy.
    (1985-11-01) Dash, R J; Sriprakash, M L; Kumar, B; Singh, S; Sharma, B R; Kaur, S
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    Adverse reactions to cosmetics.
    (2003-03-24) Dogra, A; Minocha, Y C; Kaur, S
    Adverse reaction to cosmetics constitute a small but significant number of cases of contact dermatitis with varied appearances. These can present as contact allergic dermatitis, photodermatitis, contact irritant dermatitis, contact urticaria, hypopigmentation, hyperpigmentation or depigmentation, hair and nail breakage. Fifty patients were included for the study to assess the role of commonly used cosmetics in causing adverse reactions. It was found that hair dyes, lipsticks and surprisingly shaving creams caused more reaction as compared to other cosmetics. Overall incidence of contact allergic dermatitis seen was 3.3% with patients own cosmetics. Patch testing was also done with the basic ingredients and showed positive results in few cases where casual link could be established. It is recommended that labeling of the cosmetics should be done to help the dermatologists and the patients to identify the causative allergen in cosmetic preparation.
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    Airway response to aerosol inhalations in leprosy.
    (1988-02-01) D'Souza, G A; Jindal, S K; Malik, S K; Kumar, B; Kaur, S
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    Antibodies to extractable nuclear antigens in psoriasis vulgaris.
    (1988-03-01) Sehgal, S; Kumar, B; Kaur, S; Datta, U; Anand, S
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    Antigenic differences between axenic amastigotes & promastigotes of Leishmania donovani.
    (1996-12-01) Chattopadhayay, R; Kaur, S; Ganguly, N K; Mahajan, R C
    The axenic amastigotes of an Indian strain of L. donovani have been generated from the promastigote form at 37 degrees C in RPMI-1640 medium, pH 6.0 +/- 0.5, supplemented with 10 per cent heat inactivated foetal calf serum and these are being maintained through serial subculturing under the same conditions. The present study was carried out to differentiate axenic amastigote from the promastigote stage on the basis of their antigenic constitution and also to look for any immunoreactive antigen(s) specific to axenic amastigotes. SDS-PAGE analysis revealed a few stage specific and some conserved antigenic fractions in both the stages. On immunoblotting with immune sera raised against the membrane fractions of the axenic amastigotes, the 200 kDa antigenic fraction of axenic amastigote was found to be highly reactive. When the immune sera raised against the membranes of both stages were checked by immunofluorescence no cross reactivity was observed at higher dilutions. These findings showed that there are some antigenic diversities as well as similarities between the two stages of L. donovani cultured in vitro. Also, the 200 kD fraction of axenic amastigote appeared to be an immunodominant antigen specific to that stage.
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    Antileishmanial efficacy of Boerhaavia diffusa L. and Ocimum sanctum L. against experimental visceral leishmaniasis.
    (2015-08) Kaur, S; Bhardwaj, K; Sachdeva, H
    The chemotherapy of visceral leishmaniasis (VL) has several limitations including resistance and toxicity of the existing drugs. Down regulation of immune system further aggravates the problems. To combat this situation we evaluated the leishmanicidal efficacy of Boerhaavia diffusa and Ocimum sanctum through oral route in L. donovani infection in BALB/c mice. Results have demonstrated maximum clearance of the parasites from infected animals treated with combination of B. diffusa and O. sanctum (@ 100 and 400 mg/kg body wt., respectively 5 days) as depicted through Leishman Donovan Units in liver. Up-regulation of cell-mediated immunity was also observed in animals of this group as heightened delayed type hypersensitivity responses and increased IgG2a levels were observed. Moreover, increased levels of SGOT, SGPT, serum urea, blood urea nitrogen and serum creatinine were brought down to normal levels. Since VL is associated immunosuppression, the above treatment is a good option as it helps in the up-regulation of Th1 responses and reduction in parasite load in L. donovani infected mice. These findings suggest a new option for antileishmanial chemotherapy at lower cost and nil toxicity.
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    Antimalarial potential of Nosode 30 and 200 against Plasmodium berghei infection in BALB/c mice.
    (2012-06) Bagai, U; Rajan, A; Kaur, S
    Background & objectives: Homeopathy is considered as an emerging area of alternative medicine which could be established for the global health care. One of the greatest objections to this science lies in its inability to explain the mechanism of action of the micro doses based on scientific experiments and proofs. The present study has been undertaken to screen in vivo antimalarial activity of Malaria Co Nosode 30 and Nosode 200 against Plasmodium berghei infection in BALB/c mice. Methods: Peter’s 4-day test was used to evaluate the in vivo schizontocidal effect of Nosode 30 and Nosode 200. One month follow-up study was done to calculate the mean survival time of mice in each group. Biochemical analysis was carried out to assess the liver and kidney function tests using diagnostic kits. Results: Nosode 30 and 200 exhibited 87.02 and 37.97% chemosuppression on Day 7 and mean survival time (MST) of 18.5 ± 2.16 and 16.5 ± 1.37 days respectively, which were extremely statistically significant when compared to MST of infected control (8.55 ± 0.83 days). The safety of Nosode 30 was also confirmed by the comparable levels of ALP, SGOT, SGPT activities, concentration of bilirubin, urea and creatinine to CQ treated group. Conclusion: Nosode 30 possesses considerable in vivo antiplasmodial activity against P. berghei infection as compared to Nosode 200 as evident from the chemosuppression obtained using Peter’s 4-day test. Further, studies on the drug can be carried out to establish its antimalarial potential in monotherapy or in combination with other homeopathic drug formulations.
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    Antimutagenic potential of ellagic acid isolated from Terminalia arjuna.
    (1997-05-01) Kaur, S; Grover, I S; Kumar, S
    Antimutagenic potential of a fraction isolated from Terminalia arjuna has been evaluated in TA98 and TA100 strains of Salmonella typhimurium against direct and indirect-acting mutagens. The fraction was quite effective against S9-dependent 2AF while it showed moderate effect against NPD. The fraction was analyzed to be ellagic acid.
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    Assessment of testicular volume in bacilliferous leprosy: correlation with clinical parameters.
    (1990-07-01) Abraham, A; Sharma, V K; Kaur, S
    Testicular involvement in leprosy was studied in 30 multi-bacillary (BL/LL) patients. Ten (33.3%) gave past history of type II reactions, of whom nine (30%) gave history of testicular pain and/or swelling. Decreased libido was a common complaint (63.3%). Gynaecomastia was noted in 3 patients (10%) and altered hair pattern in 11 patients (36.7%). Testicular sensation was impaired in 10 (33.3%) patients. Testicular volume was assessed objectively using the Prader orchidometer and found to be reduced in nine (30%) patients. Reduction in testicular volume correlated with longer duration of disease and a past history of type II reaction.
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    The associated diseases with leprosy.
    (1987-07-01) Singh, M; Kaur, S; Kumar, B; Kaur, I; Sharma, V K
    The prevalence of cutaneous, medical and surgical disorders was studied in 846 leprosy patients. Common cutaneous disorders among leprosy patients were pityriasis versicolor, tinea, pyodermas, warts, acquired ichthyosis, scabies, pediculosis and callosities. Only pityriasis versicolor had higher incidence when compared to general population. Common medical diseases were tuberculosis, infective hepatitis and diabetes mellitus. The epidemiological importance of their co-existence with leprosy is discussed and relevant literature of other diseases found to be frequently associated with leprosy is reviewed.
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    Authors' Response
    (Indian Council of Medical Research, 2018-09) Shafiq, N; Gautam, V; Pandey, A K; Kaur, N; Garg, S; Negi, H; Kaur, S; Ray, P; Malhotra, S
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    Bacillaemia and Mycobacterium leprae cell wall antigen in paucibacillary leprosy.
    (1993-07-01) Kaur, I; Kaur, S; Sharma, V K; Agnihotri, N; Vaishnavi, C; Ganguly, N K
    A study was undertaken to estimate bacillaemia and M. leprae antigen detection in 54 paucibacillary leprosy patients (TT, BT). Acid-fast bacilli were detected in the blood of 14.8% patients of borderline tuberculoid (BT) leprosy. M. leprae antigen was demonstrated in 48.2% patients of BT leprosy. Slit-skin smears were negative in all these patients. At the end of treatment (6 months of WHO-MDT) all the follow-up blood samples were negative for both bacillaemia and M. leprae antigen in the serum.
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    Bacillaemia in leprosy: correlation with slit-skin and nasal smears.
    (1988-10-01) Chatterjee, G; Kaur, S; Sharma, V K; Vaishnavi, C; Kaur, I
    Twenty five multibacillary patients (BL/LL) were studied for bacillaemia. Majority (76%) showed acid fast bacilli in peripheral blood. There was good correlation between bacillary load in peripheral blood and bacteriological index (BI) but poor correlation with morphological index (MI) of skin slit smear and BI/MI of nasal smear.
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    Basal cell carcinoma--treatment with cryosurgery.
    (2003-03-24) Kaur, S; Thami, G P; Kanwar, A J
    Basal cell carcinoma is a common cutaneous malignancy, frequently occurring over the face in elderly individuals. Various therapeutic modalities are available to treat these tumors. We describe three patients with basal cell carcinoma successfully treated with cryosurgery and discuss the indications and the use of this treatment modality for basal cell carcinomas.
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    BCG vaccination reaction in low birth weight infants.
    (2002-08-21) Kaur, S; Faridi, M M A; Agarwal, K N
    BACKGROUND & OBJECTIVES: About 30 per cent newborns (preterm and term) weigh < 2500 g at birth. The immunological system is less mature in low birth weight (LBW) babies compared to term and normal birth weight (NBW) babies. Bacille Calmettee Guerin (BCG) vaccine is given at birth under the national immunization programme. There is a paucity of information on the immunogenicity of BCG vaccine in preterm and LBW babies. It was, therefore, proposed to study the reaction of BCG vaccination in LBW, preterm and normal birth weight newborns. METHODS: A total of 143 newborns (90 term and 53 preterm; of these 78 were LBW) received during March to September 1998, 0.1 ml of BCG vaccine (Danish 1331 strain) intradermally on the left arm just above the insertion of the deltoid muscle within 7 days of life. At the same time trivalent oral polio vaccine was administered as per the national immunization programme. These babies were followed up in the immunization clinic at 4, 6, 8, 10 and 12 +/- 1 wk to observe reactions at the BCG vaccination site. RESULTS: After 4 wk reaction at the vaccination site was significantly (P < 0.001) delayed in preterm babies as compared to term infants, and in the LBW babies (P < 0.05) as compared to NBW babies. The reaction at the site of vaccination was not found to be different at 6, 8, 10, 12 wk. BCG scar was seen in 47.5 per cent infants (45.4% in < 2500 g birth weight and 50% in > or = 2500 g birth weight infants) at 12 wk. But 33 (42.3%) LBW and 24 (36.9%) NBW infants also showed papule, pustule, ulceration or scab at the BCG vaccination site. INTERPRETATION & CONCLUSION: The BCG reaction was seen in the sequential order from papule to scar formation. No significant difference was seen in the scar formation in infants studied with varying gestation and birth weights after 12 wk of BCG vaccination. Fifty seven (40.4%) babies still showed different stages of BCG reaction at 12 wk. BCG vaccine along with OPV administered in early neonatal life showed successful BCG reaction in 95.5 per cent infants.