Browsing by Author "Kapoor, A K"
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Item Actions of glucagon on the perfused vessels of the isolated rabbit ear.(1977-04-01) Kapoor, A K; Bapat, S K; Saxena, V CActions of glucagon on the perfused vessels of the isolated rabbit ear were investigated. The two main actions of glucagon on the perfused ear vessels of the rabbit are: (i) release of noradrenaline which accounts for the constrictor response in low tone preparations. The response depends on the level of 3, 5 AMP. If the level rises as a result of noradrenaline action, contriction sets in. (ii) Glucagon may stimulate the adenylcyclase. In the high tone preparation 3,5 AMP levels are probably high. Release of noradrenaline by glucagon would have little additonal effect.Item Acute encephalopathy due to salmonella infection.(1973-04-16) Kapoor, A K; Mathur, A; Chaturvedi, U C; Khan, A M; Mehrotra, R MItem Acute encephalopathy: a clinicopathological study.(1971-05-01) Mehrotra, R M; Mathur, A K; Khan, A M; Chaturvedi, U C; Kapoor, A KItem Amniotic fluid proteins in relation to fetal maturity.(1981-03-01) Malik, G K; Sinha, S M; Saksena, P N; Kapoor, A K; Mehra, P; Bagchi, M; Agarwal, D K; Tuteja, NItem An analysis of prescription patterns in cases of uncomplicated hypertension in a tertiary care hospital.(2012-01) Shalini; Agarwal, Sangita; Joshi, M C; Kapoor, A KBackground & objectives- Prescribing pattern in hypertension patients were found to be different from the recommended guidelines in the past. The objectives of the present study were to analyze prescribing trends in uncomplicated hypertension and to compare with those of current international guidelines with the objective to note any deviation. Methods- A prescription based analysis in 1400 hundred uncomplicated hypertensives in the age group 30 to 60 years was carried out. Results- Monotherapy was prescribed to 893 cases (M 407; F 486) and combination therapy to 507 cases (M 342; F 165). Overall, Calcium Channel Blockers (CCBs) were the most common agents used 787 (56.21%) cases, 350 monotherapy and 437 as combination therapy. Angiotensin Converting Enzyme Inhibitors (ACE I) 452 (32.28%) and Angiotensin II Receptor Blockers (ARBs) 231 (16.5%) cases were the next preferred groups. In double drug combination CCB+ Beta Blockers (BB) and for triple drug combination CCB+ARB+ Diuretics (D) were more preferred. A significant effect of age (p<0.01) on prescription of CCBs was noted. Prescription of ARBs and D were significantly (p<0.05 and <0.01 respectively) influenced by gender. Gender had no significant effect on the prescribing trend of antihypertensive agents in combination therapy, while a significant effect (p<0.05) of age and combined drug classes CCB+ACE I and CCB+BB+D was noted. The overall prescription rate for diuretics was 40.24% and that for monotherapy was meagre 5.15% (M 1.23%±; F 3.92%). Diuretics were always prescribed in triple drug combinations. Interpretation & Conclusions- CCBs were the most commonly prescribed agents. A deviation existed between antihypertensives prescribed and current international guidelines thus calling upon greater awareness.Item Antihypertensive therapy in the elderly.(1994-01-01) Kapoor, A K; Saksena, V CItem Association of genetic markers with coronary heart disease (myocardial infarction)--a case-control study.(1999-01-05) Golabi, P; Kshatriya, G K; Kapoor, A KA case-control study was carried out on patients of myocardial infarction selected from coronary care unit of Lok Nayak Jai Prakash Narayan Hospital, Delhi. The study was carried out to determine the association of haptoglobin (Hp), transferrin (Tf) and complement component 3 (C3) polymorphism with myocardial infarction. The frequency of allele Hp1 was found to be 0.159 in cases studied and 0.058 in controls. The frequency of gene TfC was found to be 0.987 in cases of study and 0.992 in controls. Similarly, frequency of CS3 gene was found to be 0.985 and 0.990 in cases studied and controls respectively. The comparison between cases studied and controls with respect to TfC and CS3 polymorphism was found to be statistically non-significant while the comparison between cases studied and controls for Hp polymorphism was found to be statistically significant (chi 2 = 21.88, p < 0.01).Item Cell mediated immune response against purified glomerular basement membrane antigen in glomerulonephritis.(1985-10-01) Natu, S M; Tewari, L; Singh, M; Gupta, A K; Kapoor, A KItem Chemo-immunotherapy and immunological study in carcinoma of larynx and laryngopharynx.(1991-08-01) Purohit, J P; Dayal, D; Kapoor, A K; Khan, I UEighteen of 25 patients had squamous cell carcinoma in the supraglottic region. Anergy to skin test antigen (DNCB) and T-cell mitogen (PHA) was observed in 17 patients with laryngeal and laryngopharyngeal malignancies. Chemo-immunotherapy did not improve the skin reactivity to either agents. However, a rise in absolute T-cell counts was observed following combined therapy. Moreover, T-lymphopenia was detected in the patient group prior to therapy as compared to mean T-cell counts in normal control subjects.Item Chikungunya virus HI antibodies in the population of Lucknow and Kanpur.(1970-03-01) Chaturvedi, U C; Mehrotra, N K; Mathur, M A; Kapoor, A K; Mehrotra, R MItem Chloroma with unusual neurological manifestations.(1974-03-01) Tripathi, B N; Kapoor, A K; Chandra, M; Agarwal, P KItem A clinical and immuno-pathological study of lymphomas.(1982-08-01) Kapoor, A K; Khan, I U; Kar, M; Nath, P; Kushwaha, M R; Misra, N C; Tuteja, N; Kumar, A; Srivastava, A N; Kar, A M; Mehrotra, R MItem Clinico-virological study of an outbreak of dengue-like illness at Hardoi (U.P.).(1974-06-01) Chaturvedi, U C; Mathur, A; Kapoor, A K; Agarwal, S K; Tandon, H O; Mehrotra, R MItem Clinico-virological study of the recurrence of dengue epidemic with haemorrhagic manifestations at Kanpur during 1969.(1972-03-01) Chaturvedi, U C; Mathur, A; Kapoor, A K; Tandon, H O; Mehrotra, R MItem A Comparative Evaluation of Losartan/ Hydrochlorothiazide (Fixed Combination) versus Amlodipine Monotherapy on Left Ventricular Hypertrophy, Biochemical Parameters and Adverse Effects in Patients of Hypertension.(2014-02) Shaifali, Iram; Kapoor, A K; Singh, H KBackground: Long-term administration of antihypertensives require better efficacy and tolerability. Moreover, the agent should regress left ventricular hypertrophy (LVH), which is an important predictor of cardiovascular events. Aims: To comparatively evaluate the effects of losartan/hydrochlorothiazide (LST/HCTZ) and amlodipine (AMLO) on LVH, biochemical parameters and adverse effects in hypertension. Material and methods: Two hundred fifty newly diagnosed hypertensive patients were randomly divided into two groups. LST 50 mg/HCTZ 12.5 mg and AMLO 5 mg once-daily, were administered. Biochemical parameters, adverse effects and ECG were recorded initially and after 6 months of therapy. Statistical analysis was done. Results: Both regimens significantly reduced mean SBP and DBP in each of the six follow ups (p < 0.001). LST/HCTZ caused regression of LVH in greater number of cases (26) than AMLO (20) and also showed a significant increase in mean values of serum creatinine, serum uric acid and high-density lipoprotein (HDL) levels and a significant decrease in Serum cholesterol. In AMLO group only serum creatinine was raised. The most common adverse effects in LST/HCTZ was dizziness (4.5%) and in AMLO group pedal edema (22%). Conclusion: Comparatively LST/HCTZ therapy causes regression of LVH in larger number of cases, increases HDL and is better tolerated.Item A continuous one year study for prevalence of enteroviruses in normal healthy children of a rural community.(1978-06-01) Mathur, A; Kapoor, A K; Chaturvedi, U C; Tandon, H O; Das, S L; Agrawal, S KItem Depressed cell mediated immunity and hyperimmunoglobulinaemia in patients with lymphomas.(1982-02-16) Tuteja, N; Kapoor, A K; Rathi, A K; Mehrotra, R M; Kumar, A; Kushwala, M RItem Detection & characterization of immune complexes in the sera of ankylosing spondylitis patients.(1985-11-01) Kapoor, A K; Agarwal, R R; Siddiqui, J S; Bhushan, V; Jain, U K; Khan, I U; Gupta, A K; Singh, G KItem Detection of anti-PPD IgG antibody and PPD-induced delayed type hypersensitivity in anterior uveitis patients.(1997-07-01) Kapoor, A K; Gopal, R; Lal, B; Asthana, O P; Agarwal, P K; Mukerjee, K; Saxena, R P; Dhawan, PPresent study relates to the results of anti-PPD IgG, anti-A60 and antinuclear antibodies and PPD-induced delayed type hypersensitivity (DTH) in 17 anterior uveitis, (AU) patients. Results of anti-PPD IgG assay revealed detection of higher mean antibody level (O.D. 0.11 +/- 0.06) compared to healthy controls (O.D. 0.04 +/- 0.03), other eye disease controls (O.D. 0.05 +/- 0.003) and leprosy controls (O.D. 0.03 +/- 0.03). Anti-A60 IgM antibody assay revealed insignificant differences in mean antibody levels between various groups. Four of 17(23.5%) AU patients and 1(5.8%) subject each, belonging to other eye disease and healthy control groups had raised anti-nuclear antibody index. Findings of PPD skin test revealed detection of moderate to strong (2 to 4+) reactivity in 14 (82%). AU patients. Conversely, 13(76%) healthy controls and 8(47%) other eye disease controls gave mild (1+) reactivity. Results of this study suggested possible role of hypersensitivity to mycobacterial antigens in pathogenesis of anterior uveitis.Item Detection of heat-labile & non-dialysable rosette-inhibiting factor in sera of lymphoma patients.(1983-07-01) Tuteja, N; Kapoor, A K; Khan, I U; Vishwanathan, P N; Gupta, A K; Kumar, A
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