Browsing by Author "Kapila, K"
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Item Antifertility effect and some pharmacological actions of Butea frondosa seed extracts.(1969-10-01) Razdan, M K; Kapila, K; Bhide, N KItem Apocrine cell carcinoma of the breast-cytopathology and ultrastructural appearance in fine needle aspirates.(1988-03-01) Kapila, K; Verma, KItem The autifertility effect of Butea frondosa petals (alcoholic extract and its crystalline fraction).(1970-07-16) Kapila, K; Bhide, N K; Razdan, M KItem Carcinoembryonic antigen & estrogen receptor protein in breast cancer.(1987-01-01) Khemani, A K; Kapila, K; Verma, KItem Chondrosarcoma--light microscopic and ultrastructural examination in fine needle aspirates.(1988-07-01) Singh, M K; Kapila, K; Verma, KItem Circumscribed eosinophilic infiltration of ileum presenting with subacute intestinal obstruction.(1983-04-01) Kar, P; Bhargava, D K; Kapoor, B M; Kapila, KItem Comparison of cefoxitin disc diffusion test, oxacillin screen agar, and PCR for mecA gene for detection of MRSA.(2009-01-28) Anand, K B; Agrawal, P; Kumar, S; Kapila, KCefoxitin is a potent inducer of the mecA regulatory system. It is being recommended for detection of methicillin resistance in Staphylococcus aureus (MRSA) when using disk diffusion testing. The aim of our study was to evaluate the efficacy of cefoxitin disc diffusion test to characterize MRSA and compare it with oxacillin agar screening and detection of mecA gene by PCR. MATERIALS AND METHODS: Fifty strains of S. aureus isolated from clinical samples were used in the study. Routine antibiotic susceptibility testing was performed including oxacillin disk. Oxacillin screen agar plates with 4% NaCl and 6 microg/ml of oxacillin were inoculated and interpreted as per standard guidelines. Cefoxitin disc diffusion test was performed using 30 microg disc and zone sizes were measured. PCR for amplification of the mecA gene was performed. RESULTS: Out of the 50 isolates, 28 were found to be methicillin resistant by oxacillin disc diffusion test, 30 were resistant by oxacillin screen agar method, and 32 were resistant with cefoxitin disc diffusion. For these 32 isolates mecA gene was positive. CONCLUSION: Results of cefoxitin disc diffusion test is in concordance with the PCR for mecA gene. Thus, the test can be an alternative to PCR for detection of MRSA in resource constraint settings.Item Cytodiagnosis of anaplastic astrocytoma with metastasis to the cerebrospinal fluid in a neonate--a case report.(2003-06-23) Goel, S; Kapila, K; Sarkar, C; Verma, KA case of left cerebral hemispheric anaplastic astrocytoma with metastasis to the cerebrospinal fluid in a 50-day-old male child diagnosed on cytology and later confirmed by histological examination is reported.Item Cytologic diagnosis of chordoma by fine needle aspiration.(1986-04-01) Verma, K; Murthy, L; Kapila, KItem Cytologic diagnosis of Enterobius vermicularis eggs in an enterocutaneous fistula.(1999-07-22) Sridhar, R; Kapila, K; Verma, KA middle-aged female underwent a laparotomy for suspected ovarian cancer and developed a discharging sinus in the right iliac fossa. Smears of the discharge showed helminthic eggs which were characterised as those of Enterobius Vermicularis. The possibility of an enterocutaneous fistula was suggested which was subsequently confirmed during a relook laparotomy.Item Cytology of cystitis cystica glandularis of the bladder--a case report.(1996-10-01) Kapila, K; Verma, KThe cytologic findings of cystitis cystica glandularis--a form of proliferative cystitis which can be mistaken for a tumor clinically and radiologically have hardly been recorded. We describe a case of cystitis cystica where the bladder washings showed a spectrum of findings which were later corroborated on biopsy.Item Diagnostic accuracy of immediate interpretation of fine needle aspirates.(1991-06-01) Verma, K; Tiwari, M C; Agarwal, J; Kapila, KA total of 197 fine needle aspirates (FNA) from various body sites was subjected to immediate interpretation to determine its diagnostic accuracy. For the entire series, the immediate interpretation revealed a sensitivity of 97 per cent, specificity of 96 per cent, a positive predictive value (PV) of 92 per cent, a negative predictive value of 98 per cent and an efficiency of the test of 96 per cent. The false positive rate was 1.5 per cent and false negative rate 0.5 per cent. The diagnostic accuracy of immediate interpretation was comparable for aspirates from different sites. Our results indicate that immediate interpretation of FNA is ideal for determining the adequacy of material and providing a rapid basic diagnosis. This technique could offer useful substitute to frozen sections particularly when facilities for the latter are not available.Item Divergent strains of human immunodeficiency virus type 1 circulating in India, subtyped by heteroduplex mobility assay.(2008-07-30) Sahni, A K; Kapila, K; Gupta, R MGenomic variations in HIV-1 represent a major problem in understanding disease progression, studying drug resistance and developing effective vaccines. Heteroduplex Mobility Assay (HMA) was used for analyzing HIV-1 subtypes resulting from genetic similarity or divergence of C2 -V3 -V5 region of envelope gene between HIV-1 strains obtained from clinical samples in a tertiary care center at Pune. DNA from the PBMCs of infected individuals was amplified by nested PCR. Heteroduplexes were then formed by denaturing DNA from the unknowns with DNA from the reference strains. The results were analyzed by polyacrylamide gel electrophoresis. Out of 177 samples analyzed, 170 were of subtype C (96%). Four samples were found to be of subtype B (2.2%); in three samples, no definitive assignment of subtype was possible by HMA and these perhaps could be circulating recombinant forms (CRFs) of HIV-1. These findings may have significant implications toward development of a candidate vaccine for India.Item Effect of intrauterine silk thread suture on fertility of female rats.(1968-01-01) Kapila, KItem Evaluation of cytologic diagnosis in bladder neoplasms.(1984-09-01) Kapila, K; Wadhwa, S N; Verma, KItem Evaluation of grading of breast carcinoma on needle aspirations and tissue section.(1986-09-01) Kapila, K; Sahoo, M; Verma, KItem Extramedullary involvement in acute lymphoblastic leukemia and its relation to therapy.(1991-07-01) Rao, A V; Verma, K; Kapila, K; Choudhry, V P; Pati, H PExtramedullary involvement (EMI) of various body sites was studied by doing CSF cytology anu FNAC of testes and lymph nodes in 82 children with acute lymphoblastic leukemia (ALL). Forty-five patients had received no therapy (group I) and 37 had been diagnosed and treated earlier and were now in remission (36) or relapse (group II). EMI was documented in 48.9% and 32.4% of patients of group I and II respectively. EMI was seen more frequently in patients with FAB-L 2 subtype (66.6%) as compared to FAB-L1 subtype (34.6%) in group I. Lymph nodes and testes were commonly involved in group I and II patients respectively. Successful remission after complete chemotherapy was achieved in 82.5% of group I patients. However, successful remission rates were 95.2% in patients without any evidence of EMI versus 68.4% in those with EMI. These differences were also observed when response to therapy was analysed separately for patients with FAB-L1 and FAB-L2 subtypes.Item Fine needle aspiration cytology in diagnosis of hepatic malignancy.(1986-06-01) Verma, K; Bhargava, D K; Tandon, M; Chawla, Y K; Babu, S; Kapila, KItem Fine needle aspiration cytology in pediatric oncology.(1988-05-01) Verma, K; Kapila, KItem Fine needle aspiration cytology, sonography and radionuclide scanning in solitary thyroid nodule.(1992-05-01) Kumar, A; Ahuja, M M; Chattopadhyay, T K; Padhy, A K; Gupta, A K; Kapila, K; Goel, A K; Karmarker, M GOne hundred and ninety three consecutive patients with solitary thyroid nodule (STN), with a mean age of 36.0 +/- 12.8 years and male to female ratio of 5.6:1, were studied. Ninety five percent of patients came from iodine deficient regions. Seventy two percent presented for local neck swelling, 12.4% for hyperthyroid state and in 7.7% STN was discovered incidentally. Scintigraphically, 77.7% of nodules were cold, 12.4% hot and 8.5% warm. Sonographic evaluation did not reveal any characteristic echotexture diagnostic of malignancy, but detected clinically nonpalpable accessory nodules in 20.6% of patients. Fine needle aspiration cytology was positive for malignancy in 6.2% of patients. Features of follicular and Hurthle cell neoplasm were seen in 12.9% of aspirates. Eighty eight (45.6%) STN were resected surgically. Histologically, there was one false positive and one false negative aspirate and a case of parathyroid adenoma on aspiration proved to be parathyroid carcinoma on histology.