IMSEAR Repository :: Browsing by Author "Kalra, V"

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Abnormal lactic dehydrogenase isoenzymes in patients of Indian childhood cirrhosis and their siblings.

(1980-11-01) Kalra, V; Sharma, P U; Roy, S; Ghai, O P

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Adhalin deficiency: an unusual cause of muscular dystrophy.

(2001-11-05) Dua, T; Kalra, V; Sharma, M C; Kabra, M

Childhood muscular dystrophies have a wide clinical spectrum, motor disability and are variably inherited. Although the phenotype may appear similar they may represent distinct genetic entities. Advances in immunohistochemistry, gene deletion and linkage studies have enabled precise characterization. We report a family with an early onset weakness and calf pseudo hypertrophy in 2 male sibs with an usually mild course. Deletion screening was negative for 24 exons of the DMD gene in both. Muscle immunohistochemistry revealed normal dystrophin I and II staining but complete absence for adhalin, a dystrophin associated glycoprotein. Classifying them as adhalinopathy. Severe childhood autosomal recessive muscular dystrophies (SCARMD) result from mutation in the sarcoglycan complex (59). Adhalinopathy is now used to describe SCARMD. The adhalinopathy described in our patients is the first report from India.

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Alternating hemiplegia of childhood.

(1996-03-01) Kalra, V; Rathi, S

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Anaclictic depression--an attachment disorder of infancy.

(1985-03-01) Agarwal, R K; Moudgil, A; Biswas, D; Bagga, A; Kalra, V; Chawla, P

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Angiotensin and its inhibition: a nephrologist point of view.

(2002-10-06) Kalra, V; Agarwal, S K; Wani, M

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An approach to neurometabolic disorders by a simple metabolic screen.

(2000-01-04) Gulati, S; Vaswani, M; Kalra, V; Kabra, M; Kaur, M

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Awareness about taeniasis and neurocysticercosis among municipal schoolteachers in Delhi.

(2007-12-14) Mishra, D; Kalra, V; Aggarwal, K

Taenia solium is the commonest parasitic infection of CNS and an important cause of new-onset seizures and epilepsy in children and adults. Human activities impact on almost every one of the stages of the lifecycle of the worm as man is responsible for dispersion of the parasite's egg through outdoor defecation and indiscriminate disposal of feces. Health education to cause behavioral changes in these practices can therefore be an effective intervention strategy. We conducted a study to assess KAP regarding taeniasis and neurocysticercosis among municipal school teachers in Delhi. The findings are presented in this communication. The study revealed that, general information related to personal food hygiene was known to majority of the teachers but core information in the context of taeniasis/cysticercosis and seizure prevention was lacking.

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Biochemical profile of copper in patients and siblings of Indian Childhood Cirrhosis.

(1982-11-01) Kalra, V; Ghai, O P; Shapcott, D

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Biotinidase deficiency--a treatable entity.

(2000-06-10) Gulati, S; Passi, G R; Kumar, A; Kabra, M; Kalra, V; Verma, I C

Biotinidase deficiency is a well recognised treatable cause of a wide spectrum of progressive neurological symptoms. Recent reports have stressed the need to screen children with early onset of seizures, encephalopathy, neurodevelopmental delay, skin rash and alopecia. Enzyme estimation remains the conclusive test. We present a patient with biotinidase deficiency suspected on the above clinical grounds and diagnosed on the basis of metabolic acidosis, raised blood lactate, ketonuria and positive dinitrophenylhydrazine (DNPH) test and confirmed on urinary organic acid profile. Supplementation with biotin resulted in marked clinical improvement and normalisation of metabolic parameters. Thus the clinician should be alert to simple clinical pointers which aid in early diagnosis of these disorders.

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The brachioradialis reflex.

(1999-07-31) Kalra, V; Mittal, R

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Cardiac tamponade in juvenile rheumatoid arthritis.

(1988-09-01) Bagga, A; Kabra, S K; Shankar, V; Kalra, V

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Chediak Higashi syndrome.

(1982-11-01) Seth, P; Bhargava, M; Kalra, V

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A comparative analysis of 125 neonatal autopsies.

(1979-01-01) Kalra, V; Singh, M

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Congenital fiber type disproportion: a rare type of congenital myopathy: a report of four cases.

(2004-06-23) Sharma, M C; Ralte, A M; Atri, S K; Gulati, S; Kalra, V; Sarkar, C

Congenital fiber type disproportion is a rare type of congenital myopathy which presents as hypotonia, delayed motor milestones and dysmorphic facies. During the past 2 years we received 449 muscle biopsies, of which 4 cases were diagnosed as congenital fiber type disproportion (CFTD). In addition to CFTD, one case also had centronuclear features. Three of them were females and one was a male child. Although rare, it should be considered in the differential diagnosis of childhood muscle diseases. Histochemical staining is necessary for the diagnosis of this entity.

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Congenital myotonic dystrophy.

(2001-05-16) Gulati, S; Kabra, M; Gera, S; Kalra, V; Saxena, R; Verma, I C

Myotonic muscular dystrophy is the most frequent autosomal muscular dystrophy affecting adults and children. It affects multiple organ systems and is probably the best example of variable expressivity in a human disease. This article presents a patient with congenital myotonic dystrophy who had facial dysmorphism, hypotonia, talipes, feeding and respiratory difficulties in the neonatal period and later presented to us with developmental delay and had percussion myotonia. His mother had clinical and electrophysiological features of myotonia. Expansion of unstable CTG trinucleotide repeat in the myotonic protein kinase gene was demonstrated in both. The identification of this molecular defect allows its specific diagnosis in relation to other neuromuscular disorders as well as accurate prenatal diagnosis.