Browsing by Author "Kalapala, Rakesh"
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Item Role of magnification endoscopy in the diagnosis and evaluation of suspected celiac disease: correlation with histology.(2007-03-15) Banerjee, Rupa; Shekharan, Anuradha; Ramji, C; Puli, Srinivas R; Kalapala, Rakesh; Ramachandani, Mohan; Gupta, Rajesh; Lakhtakia, Sandeep; Tandan, Manu; Rao, G V; Reddy, D NageshwarBACKGROUND: Magnification endoscopy (ME), with 115-fold magnification, allows visualization of duodenal villi. We assessed the efficacy of ME for evaluation of villous atrophy. METHODS: ME and duodenal biopsy were done in 16 patients with suspected celiac disease and 16 control subjects undergoing endoscopy for reflux symptoms. The pathologist was unaware of the ME findings. RESULTS: Sensitivity, specificity and positive and negative predictive values for villous atrophy (partial or total) were 100%, 91%, 83% and 100%, respectively. Corresponding values for normal villous structure were 91%, 100%, 100% and 83%, respectively. There was significant concordance between the ME and histology findings. CONCLUSION: ME is a reliable technique to diagnose villous atrophy.