Browsing by Author "Joshi, Shalaka"
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Item Breast cancer in a tertiary cancer center in India - An audit, with outcome analysis(Indian Cancer Society, 2018-01) Nair, Nita; Shet, Tanuja; Parmar, Vani; Havaldar, Rohini; Gupta, Sudeep; Budrukkar, Ashwini; Sarin, Rajiv; Thakur, Meenakshi; Desai, Sangeeta; Yadav, Prabha; jalali, Rakesh; Gulia, Seema; Wadasadawala, Tabassum; Gosh, Jaya; Bajpai, Jyoti; Kembhavi, Seema; Patil, Asawari; Joshi, Shalaka; Popat, Palak; Rangarajan, Venkatesh; Shah, Sneha; Vanmali, Vaibhav; Siddiqui, Shabina; Mittra, Indraneel; Badwe, RajendraBackground: Surgery is the mainstay in the management of thyroid cancer. Surgical outcomes need to be tempered against the excellent prognosis of the disease. Aims: This study aims to study the surgical outcomes including the 30-day morbidity and 5-year survival of thyroid cancer patients. Settings and Design: Retrospective analysis of a prospectively maintained surgical database in a tertiary cancer center in India. Materials and Methods: We analyzed 221 surgically treated patients in the year 2012. Statistical Analysis: Used IBM SPSS 24.0 (Armonk, NY) with p < 0.05. Results: The median age was 40 years with predominantly papillary thyroid carcinoma (55%). Localized disease in 47% of cases, locoregional disease in 42.5% and distant metastasis in 10.2% of cases at presentation was noted. Treatment naïve patients were 71% and revision surgeries were done in 29% patients. Extended thyroidectomy constituted 11% of the surgeries. Temporary hypocalcemia was seen in 30.8% of patients, 5% requiring intravenous calcium supplementation. Vocal cord palsy as per nerve at risk and chyle leak were seen in 4.5% and 3.1%, respectively. Aggressive histology, extended thyroidectomy, and inadvertent parathyroidectomy were significant factors associated with complications. Five year estimated overall survival with median follow-up of 50 months was 98%, and event-free survival was 84.8%. Advanced age, distant metastasis at presentation and aggressive histology connoted poor outcomes. Conclusion: Thyroid cancer, irrespective of the extent of disease, has good prognosis. Aggressive histology, the extent of thyroid surgery, distant metastasis and age are important factors, which should be factored in the algorithm of thyroid cancer management.Item Survival outcomes with 12 weeks of adjuvant or neoadjuvant trastuzumab in breast cancer(Wolters Kluwer - Medknow, 2022-09) Ghosh, Joydeep; Phillip, Deepa S Joy; Ghosh, Jaya; Bajpai, Jyoti; Gulia, Seema; Parmar, Vani; Nair, Nita; Joshi, Shalaka; Sarin, Rajiv; Budrukkar, Ashwini N; Wadasadawala, Tabassum; Desai, Sangeeta B; Shet, Tanuja; Patil, Asawari; Sawant, Sheela P; Dhir, Aruna A; Kembhavi, Seema; Popat, Palak; Hawaldar, Rohini; Kembhavi, Yogesh; Perumal, Prema; Banavali, Shripad D; Badwe, Rajendra A; Gupta, SudeepBackground: There is limited access to 1 year of adjuvant trastuzumab in resource-constrained settings. Most randomized studies have failed to prove non-inferiority of shorter durations of adjuvant trastuzumab compared to 1 year However, shorter durations are often used when 1 year is not financially viable. We report the outcomes with 12 weeks of trastuzumab administered as part of curative-intent treatment. Methods: This is a retrospective analysis of patients treated at Tata Memorial Centre, Mumbai, a tertiary care cancer center in India. Patients with human epidermal growth factor receptor (HER2)-positive early or locally advanced breast cancer who received 12 weeks of adjuvant or neoadjuvant trastuzumab with paclitaxel and four cycles of an anthracycline-based regimen in either sequence, through a patient assistance program between January 2011 and December 2012, were analyzed for disease-free survival (DFS), overall survival (OS), and toxicity. Results: A total of 102 patients were analyzed with a data cutoff in September 2019. The median follow-up was 72 months (range 6–90 months), the median age was 46 (24–65) years, 51 (50%) were postmenopausal, 37 (36%) were hormone receptor-positive, and 61 (60%) had stage-III disease. There were 37 DFS events and 26 had OS events. The 5-year DFS was 66% (95% Confidence Interval [CI] 56–75%) and the OS was 76% (95% CI 67–85%), respectively. Cardiac dysfunction developed in 11 (10.7%) patients. Conclusion: The use of neoadjuvant or adjuvant 12-week trastuzumab-paclitaxel in sequence with four anthracycline-based regimens resulted in acceptable long-term outcomes in a group of patients, most of whom had advanced-stage nonmetastatic breast cancer.