Browsing by Author "Joseph, A."

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    Application of Chitin Improves Growth, Yield and Secondary Metabolite Production in Turmeric (Curcuma longa L.)
    (Ms. M. B. Mondal, 2023-12) Shibana, S. N.; Nair, DS; Sreekala, G. S.; Shalini Pillai, P.; Alex, S; Joseph, A.
    A field experiment was conducted in Trivandrum district during June 2021 to January 2022 to evaluate the effect of chitin on growth, yield and secondary metabolite production in turmeric. Soil application of chitin at 5 g per plant was done at 60 and 180 days after transplanting, while untreated plants served as control. Observations were recorded on effect of chitin on growth, defense enzymes, yield, secondary metabolites and disease incidence. Results of the study confirmed significant enhancement in growth, yield and secondary metabolite production on chitin application compared to the untreated control. Significant increase in shoot weight and rhizome weight was observed at six months after transplanting in response to chitin application. Fresh and dry rhizome yield per plant increased by 60.16% and 65.97% respectively, over the control. The defense enzyme activity and chlorophyll content were significantly higher in plants subjected to chitin application, compared to the control. Chitin treatment enhanced volatile oil and oleoresin content by 1.39 and 1.41 times and curcumin content by 21%, over the control. The results confirmed that chitin is a potent biostimulant that can be used for growth, yield and quality enhancement in turmeric.
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    A study on pharmacist intervention in anti-epileptic drugs at a tertiary care hospital
    (Medip Academy, 2024-08) Joseph, A.; Rajan, C.; Kharlynnai, D.; P. V., V.
    Background: Antiepileptic drugs (AEDs) have been used for the treatment of epilepsy and other neurological disorders since 19th century. Several classes of AEDs are available for epilepsy, many of them are also used for migraines, bipolar disorder, schizophrenia, depression, and neuropathy. Methods: Total 212 patients participated in an Ambi-directional observational cohort study conducted at Mallige medical center, Bangalore. Reviewed and evaluated both inpatients and outpatients case sheets and the data were entered into Microsoft excel. The data was analysed using version 27 of SPSS and statistical significance was determined by using p value less than 0.05 and Pearson correlation. Results: The result show that among 212 patients 130 were males and 82 females and the major risk factors were hypertension and type 2 diabetes mellitus. Levetiracetam and pregabalin were the commonest AED prescribed. Among 109 adverse drug reaction (ADRs) occurred in 82 patients, dizziness, and sedation (20%) were common. Valproate (17.4%) was the main drug causing ADRs and treatment was discontinued in 2 patients due to phenytoin (PHT) toxicity. A total of 90 drug-drug interaction (DDI) was observed using online drug database. Conclusions: This study revealed that monitoring and evaluating the prescription pattern in these patients enables modification in prescribing pattern that improves the patient抯 quality of life and can reduce drug related problems. Clinical pharmacist plays an important role in evaluating the prescribing pattern of drugs based on standard treatment guidelines and rationality of prescriptions.