Browsing by Author "Jeyanthikumari, T"
Now showing 1 - 2 of 2
Results Per Page
Sort Options
Item Diabetes and oral health- An overview of clinical cases.(2015-07) Thayumanavan, B; Jeyanthikumari, T; Abu, Dakir; Vani, NVDiabetes Mellitus is a chronic disease prevalent worldwide with an increasing frequency of occurrence. Diabetes produces a wide array of symptoms throughout the body. It is said that mouth is the mirror of systemic health. The effects of diabetes are most frequently reflected in the oral cavity. Gingivitis and periodontitis are most frequently associated with diabetes. Periodontitis has been reported as sixth complication of diabetes and they both exhibit a bidirectional interrelationship. This article reviews about the oral lesions occurring in diabetes and their pathogenesis. This article also focuses on the interrelationship between diabetes and oral health stressing the need for oral health assessment and treatment as part of preventive medical therapy for diabetes.Item The evaluation of the amount and sustain release of antifungal agent clotrimazole incorporated in different polymer matrix in artificial saliva at a pH of 6.2.(2015-10) Sabarigirinathan, C; Vinayagavel, K; Rupkumar, P; Prabhu, G Sriram; Jeyanthikumari, T; Rajakumar, M; Chubey, Anshul; Meena, N Sangeetha; Elavarasan, SBackground: Candidiasis in the oral cavity is an opportunistic infections, the most common species involved is Candida albicans. Clotrimazole (CTZ) is the first line broad-spectrum antifungal drug that has been widely used for the prophylaxis and treatment of oral and vaginal candidiasis. It is seen that the effect of drug is better locally as compared to oral intake. The aim of the present study is to find out the quantum release of clotrimazole from the incorporated materials in the artificial salivary medium at the pH of 6.2 and to access the physical properties of the clotrimazole incorporated reliner and tissue conditioner. Methods: The antifungal clotrimazole is incorporated in two types of denture base material used for this study at 2%, 5% and 10% concentration by weight. The release of clotrimazole out of polymer matrix was studied at various pH. The main property of tensile strength of the specimen before and after the chemical release of the clotrimazole was tested. Result: Concentration was maximum on 8th day and uniformly decreased thereafter. The maximum amount of release upto 8th day was 2.52, 4.23, 9.84 mg for 2%, 5% and 10% respectively. Conclusion: Topical release of antifungal agents is more effective than systemic intake, which has adverse effect like renal toxicity and CNS toxicity.