Browsing by Author "Jaiswal, Rohit"

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    Association of Ki-67 antigen and p53 protein at invasive tumor front of oral squamous cell carcinoma.
    (2014-10) Verma, Ruchita; Singh, Anil; Jaiswal, Rohit; Chandra, Akhilesh; Verma, Renuka; Tak, Jalaj
    Aim: Studies reveal that invasive tumor front may be the best field for quantifi cation of proliferative and apoptotic markers. The current study assessed the expression of Ki-67 antigen and p53 protein at invasive tumor front of oral squamous cell carcinoma (OSCC) and correlated the immunostaining with the histologic grades of malignancy. Materials and Methods: A total of 80 slides sample was prepared for the study, one each from ten normal oral mucosa cases and two each from 30 OSCC cases. The OSCC patients were biopsied along invasive tumor front, and samples were immunohistochemically analyzed for the expression of both Ki-67 antigen and p53 protein. Results: Of the total 30 OSCC cases, the expression of p53 was found positive in 20 cases (66.6%), while Ki-67 expression was found positive in 21 cases (70%). All the cases in the control group were negative. A higher p53 and Ki-67 expression were seen in OSCC group as compared to normal mucosa. On comparing the control group with various grades of OSCC a statistically signifi cant result was obtained. Conclusion: Higher and statistically signifi cant expression was noted for both p53 and Ki-67 antigen. The results emphasize the potential of Ki-67 and p53 as biomarkers of carcinogenesis in OSCC. Ki-67 expression was comparatively higher when compared with p53 except in poorly differentiated squamous cell carcinoma and signifi es actively proliferating malignant cells at invasive tumor front.
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    Oro-facial granulomatosis - A case report.
    (2012-10) Jaiswal, Rohit; Chaudhary, Sarita; Singh, Priyanka; Gupta, Manvi
    Oro-facial granulomatosis includes a group of disorders which present as a chronic, non-ceasating granulomatous lesion involving the perioral tissues of face and oral mucosa. This condition was first referred by Mart in 1859, Hubschmann in 1894 and Luscher in 1949; later, Wiesenfeld in 1985 introduced the term “Oro-facial Granulomatosis” (OFG) which is characterized by persistent or recurrent soft tissue enlargement and oral ulceration. Hence, it is important to establish the diagnosis accurately because this condition sometimes is a manifestation of Crohn’s disease or Sarcoidosis. A case of Orofacial granulomatosis in a 15-year-old male is reported.