Browsing by Author "Jaiswal, R"
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Item Correlation between Bath Ankylosing Spondylitis Disease Activity Index Score and body mass index in the patients suffering with ankylosing spondylitis(Mrs Dipika Charan of MedScience (India) Publications, 2023-06) Roy, A; Jayanthi, A; Jaiswal, R; Singh, SK.Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease of the axial spine that can manifest with various clinical signs and symptoms. Chronic back pain and progressive spinal stiffness are the most common features of this disease. It is an autoimmune disease which also leads to the involvement of skeletal, cardiac, nervous tissues, and other systemic organs. Aim and Objectives: This study was conducted to assess the correlation between the Bath AS Disease Activity Index (BASDAI) score/visual analog scale (VAS) and various age groups in the patients suffering with AS using standard questionnaire. Materials and Methods: Forty-eight AS patients having BASDAI scores of ?4 were included in this study. The height and weight were taken and responses to the standard questionnaire were recorded. BASDAI Score, body mass index (BMI), and VAS were computed. The patients with history of chronic diseases such as hyper/hypothyroidism, diabetes mellitus, and hypertension or the use of any medication such as ?/? blockers, calcium channel blockers, and antiepileptics were excluded from the study. Results: The patients were divided into six different age groups, i.e., 15–20 years, 21–25 years, 26–30 years, 31–35 years, 36–40 years, and 41–45 years. The mean ± SEM values of the BASDAI score in various age groups were 6.8 ± 0.34, 6.3 ± 0.33, 6.2 ± 0.26, 7.1 ± 0.41, 6.5 ± 0.30, and 5.8 ± 0.48, respectively. The mean ± SEM values of VAS are shown in relation to the various age groups, i.e., 15–20 years, 21–25 years, 26–30 years, 31–35 years, 36–40 years, and 41–45 years and the values were 6.88 ± 0.312, 6.58 ± 0.22, 6.55 ± 0.66, 6.00 ± 0.23, 6.72 ± 0.25, and 6.0 ± 0.50, respectively. Conclusion: This study indicates that in the young age group, patients BASDAI score is higher and BMI is lower, and in the older age group, patients BASDAI score is lower and BMI is higher than each other indicating higher disease activity in the younger patients than older patients. An inverse correlation between VAS and age further substantiates our previous finding.Item Development and evaluation of an in vitro isolation of street rabies virus in mouse neuroblastoma cells as compared to conventional tests used for diagnosis of rabies.(2007-07-29) Chhabra, M; Mittal, V; Jaiswal, R; Malik, S; Gupta, M; Lal, SIn vitro isolation of rabies virus using mouse neuroblastoma cells (MNA) was evaluated. The sensitivity and reliability of in vitro procedure was performed in comparison with mouse inoculation test (MIT), the in vivo method of virus isolation, direct fluorescent antibody test (FAT) and Sellers staining. Of the 33 animal brain samples tested, 24 (72.72%) were positive by MIT. Sensitivity of Sellers stain, FAT and rapid tissue culture infection test (RTCIT) was found to be 54.16, 100 and 91.6% respectively. Concordance of Sellers stain, FAT, RTCIT with MIT was found to be 66.6, 100 and 93.93% respectively. Two samples which were positive by FAT and MIT showed gross contamination in cell lines, which is one of the drawbacks of RTCIT. However, rabies virus could be isolated in MNA cells from two of the eight human cerebrospinal fluid (CSF) samples from clinico-epidemiologically suspected cases of rabies. Both MIT and FAT showed negative results in the two CSF samples. RTCIT appears to be a fast and reliable alternative to MIT and holds promise in antemortem diagnosis of rabies, which is otherwise, a challenging task for a reference laboratory.Item Existing challenges and histopathological review of borderline ovarian epithelial tumors(Medip Academy, 2024-10) Singh, R; Raman, E; Agarwal, P; Maurya, MK; Jaiswal, R; Gupta, S; Solanki, V; Agarwal, S; Singh, AK.Background: The borderline tumour seen in the ovary can be with or without stromal invasion. Diagnosis and application of the correct criteria are of utmost importance to avoid over or undertreatment of these. We analyzed the borderline tumors reported in 2 years with respect to clinical outcome based on the morphological diagnosis and points that needed reconsideration. Methods: Cases reported as borderline tumors in ovary were retrieved from records reviewed and follow up was recorded. Additionally, we performed a morphometric analysis to confirm the maximum size of the invasive front. Results: A total of 467 resected ovarian tumor specimens were received, of which 266 (266/467 *100=56.9%) were epithelial tumors; out of them 54.88% were benign, 4.88% were borderline and 40.22% were malignant. The mean age at the time of borderline diagnosis was 38.66 years. On follow-up two cases among them developed further disease. One was reported from our center and one from outside, both were mucinous-type tumors. On critical review we found that there was minimal nuclear atypia in both, there was no evidence of convincing stromal invasion except few irregular well formed glands were seen infiltrating the stroma in one case. Conclusions: A large multicenter, interdisciplinary collaboration and data-driven study is needed to reconfirm and reconsider the cut-off of 5mm especially in mucinous tumors.Item Malignant melanotic nerve sheath tumour of chest wall: a rare and diagnostically challenging case(Medip Academy, 2024-11) Qayoom, S; Goel, D; Jaiswal, R; Akhtar, N.Malignant melanotic nerve sheath tumour (MMNST), previously known as melanotic schwannomas (MS) comprise less than 1% of nerve sheath tumors and around 200 cases have been reported in the literature. According to the WHO 5th edition, it is now classified as malignant neoplasm due to its local recurrence rate and metastatic risk. Although it is classified as malignant, the histopathological criteria for malignancy and prognostic factors remain ill-defined due to its rarity. It also poses a diagnostic challenge as it resembles closely other benign as well as malignant melanin producing tumors. We report here a case of 33 year old female who presented with chest wall swelling and was diagnosed as MS (now classified as MMNST) on histopathology and immunohistochemistry. This case highlights the diagnostic difficulties and the importance of careful histological evaluation and long-term follow-up.Item Unmasking the enigma - recurrent odontogenic keratocyst: a continual challenge(Medip Academy, 2024-09) Dua, P; Ghosh, S; Khalid, S; Grover, M; Jaiswal, R; Gupta, A.Odontogenic keratocysts (OKCs) represent 10% to 14% of all jaw cysts and are notable for their high recurrence rate compared to other odontogenic cysts. This case study details a recurrent OKC in a young woman, highlighting the critical need for diligent long-term follow-up and effective management strategies. A 25-year-old female presented with a recurrent OKC in the maxilla. The treatment involved surgical enucleation of the cyst, apicectomy of affected teeth, and application of Carnoy's solution to reduce recurrence risk. Follow-up imaging and clinical evaluations were conducted periodically to monitor healing and detect potential recurrences. Postoperative recovery was uneventful, with no immediate complications. Serial radiographs and clinical examinations during the follow-up period showed satisfactory healing and no signs of recurrence. The patient reported no discomfort or functional impairment. This case underscores the importance of comprehensive surgical intervention and long-term follow-up in managing recurrent OKCs. The combined approach of cyst enucleation, apicectomy, and Carnoy's solution application proved effective in preventing recurrence in this patient. Ongoing monitoring remains essential to ensure early detection and management of potential recurrences, ultimately improving patient outcomes.