Browsing by Author "Jain, V."
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Item Role of Autologous Platelet Derived Growth Factor and Fibrin Rich Plasma in Management of Chronic Non-healing Ulcer–A Pilot Study.(2016) Patel, Suprava; Bhargava, Piyush; Jain, V.; Tucker, O. P.; Khodiar, P. K.Background and Objectives: Chronic non-healing ulcer (CNHU) develops due to infections, trauma or underlying any medical and surgical conditions. Ulcer that have failed to response all available mode of treatment for long duration are more likely to develop gangrene and infection prone to limb amputation. This is a major public health problem. None of the conventional treatments are anticipated to stimulate active wound healing. The objectives of this study is to test the efficacy of topically applied autologous platelet derived growth factors and fibrin rich plasma in active repair of chronic non healing ulcer. Methods: Patients having one or more ulcers who have been receiving conventional treatment for their at least for more than 6 months duration but showed no evidence of healing till date were included in this study. Total of 30 skin ulcers were registered, of which 15 patients did not return for follow up. Rest 15 patients were included as the study group. All ulcers were treated with autologous platelet derived growth factors and fibrin rich plasma enriched antibiotic ointment. We observed that 73.33% ulcers were complete healed & rest ulcers had signs of improvement. Results: The study group showed complete healing in 73.33% ulcers and average 80% improvement observed in each ulcer, after applying autologous platelet derived growth factors and fibrin rich plasma. Significant ulcer healing was observed in patients who were less than 40 years of age, had no history of addiction for any toxic substance, and had ulcer size less than 30 sq cm. Ulcer healing rate was also found to be higher in cases whose duration of ulcer was within one year and those who did not have any history of systemic diseases. Conclusion: This study clearly shows the efficacy of topically applied autologous platelet derived growth factors and fibrin rich plasma in management of chronic non-healing ulcer.Item An Unusual Case of DRESS Syndrome Presenting with Marked Leucocytosis.(Light House Polyclinic, 2023-03) Bisht, P; Khetrapal, S; Sehgal, S; Jetley, S; Jain, V.Drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a rare severe drug-induced idiosyncratic hypersensitivity characterized by maculopapular and/or erythrodermic eruption, fever, peripheral lymphadenopathy, eosinophilia or atypical lymphocytosis, and visceral organ involvement. The estimated incidence of this syndrome ranges from 1/1000 to 1/10,000 drug exposures. In this report, we describe a case of DRESS syndrome in a young female with a unique presentation. The DRESS syndrome can be difficult to diagnose as its clinical findings can mimic those of other systemic diseases. This case emphasizes the importance of incorporation of the patient’s clinical and medication history in the interpretation of hematological investigations.Item Untitled(Educational Society for Excellence, 2016) Jain, R; Gupta, P; Jain, V.Background: PCEA (patient controlled epidural analgesia) is a safe and effective technique for postoperative analgesia on routine surgical wards. Use of the epidural catheter as part of a combined epidural-general anesthetic technique results in less pain and faster patient recovery immediately after surgery than general anesthesia followed by systemic opioids does. Aim: In this prospective, randomized, double – blind study, we compared the analgesic effectiveness, hemodynamic changes and other side effects of epidural analgesia with drug combination – bupivacaine with fentanyl and ropivacaine with fentanyl in different concentrations. Material and methods: It was a prospective, randomized, double – blind study. Sixty patients of ASA I-II and age group 18-65 years divided in four groups 15 patients in each group (Group B1 bupivacaine 0.1%; Group B2 bupivacaine 0.05%; Group R1 ropivacaine 0.1%; Group R2 ropivacaine 0.05% with fentanyl 5micrograms/ml in each groups). After taking consent from patients epidural catheter was placed and study drugs were given to every patient. Visual analogue scale, heart rate, Jain R, Gupta P, Jain V. A comparison of ropivacaine with fentanyl to bupivacaine with fentanyl for post-operative patient controlled epidural analgesia in patients undergone lower abdominal cancer surgery. IAIM, 2016; 3(7): 137-149. Page 138 blood pressure, sedation score, modified bromage scale and other side effects were noted for the next 48 hours. Statistical analysis was done by using Medcalc 12.2.1.0 version statistical analysis software. Results: All four groups were comparable in terms of analgesia but group B1 patients had significant decrease in blood pressure at all time intervals. This group also had loss in motor power of lower extremity p value 0.020 than all other three groups. Conclusions: We concluded that ropivacaine 0.1% with fentanyl 5 µg/mL after major abdominal surgery provides optimal dynamic analgesia without significant adverse effects.