Browsing by Author "Jain, R K"
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Item Abdominal hernia following abdominal herpes zoster.(2001-01-01) Sharma, P K; Gautam, R K; Basistha, C; Jain, R K; Kar, H KWe report a case of abdominal hernia in TIO and 11 segments following herpes zoster at T11 segment.Item Acute hydrops in keratoglobus with vernal keratoconjunctivitis.(1985-03-01) Gupta, V P; Jain, R K; Angra, S KItem Anti-implantation effect of neem oil.(1984-12-01) Sinha, K C; Riar, S S; Bardhan, J; Thomas, P; Kain, A K; Jain, R KItem Anti-stress activity in a muramyl-dipeptide.(1990-07-01) Singh, N; Jain, R K; Gupta, C M; Anand, NN-Acetylmuramyl-L-alanyl-D-isoglutamine and some of its derivatives have been examined for anti-stress activity. Amongst these, N-palmitoylmuramyl-L-alanyl-D-isoglutamine is shown to considerably enhance the capacity of animals to endure various types of stress. This indicates that besides acting as immunomodulators and sleep regulators, muramyl dipeptides may also act as anti-stress agents.Item Care of mentally ill patients.(1980-10-01) Malik, S C; Jain, R KItem Cataract in childhood--etiological appraisal.(1983-09-01) Angra, S K; Saini, J S; Mohan, M; Jain, R KItem Characteristics of phosphatidylcholine/peptidylglycolipid liposomes.(1984-02-01) Jain, R KItem Clinico-therapeutic profile of pyogenic liver abscess.(1993-03-01) Nigam, P; Kapoor, K K; Sarkari, N B; Jain, R K; Gupta, A K; Sharma, S P; Mishra, S DNineteen consecutive patients of pyogenic liver abscess (13 males, 6 females, mean age 45.2 +/- 6, 5 years) were studied over a period of 5 years for the clinical profile and therapeutic efficacy of percutaneous aspiration. Majority of them presented with spiking fever (94.7%), pain over right upper quadrant of abdomen (53.8%) and often with prostration and shock (31.6%). The onset has been rather acute in patients with multiple abscesses (7 cases). Ascites (10.5%), clubbing of fingers (15.8%) and splenomegaly (10.5%) were observed in cases with long duration of illness. There has been the polymorphonuclear leucocytosis (89.5%) and mild to moderate anaemia (52.6%). Jaundice (42.1%) was usually mild degree (serum bilirubin 4.6 +/- 2.4 mg/dl). The serum transaminases and alkaline phosphatase were raised in 94.9% of cases. Ultrasonography revealed predominantly hypoechoic (54.1%) areas with frequent distal acoustic enhancement and internal echoes (21.6%). Seven patients had multiple abscesses with 25 lesions (size 5.2 +/- 4.6 cms) situated mainly over antero-inferior segment of the right lobe (45.9%) of the liver. The blood and pus cultures demonstrated the micro-organisms (positive in 63.9% and 86.6% respectively) predominantly of bowel flora including facultative gram negative rods and anaerobes. Mortality was 26.5% and pleuro-pulmonary complications were the commonest (26.4%) one. 15 cases were treated by percutaneous aspiration, proper antibiotic and metronidazole with encouraging results (only two deaths). Complete resolution of abscess took place in 14.2 +/- 1.2 weeks (range 6 weeks to 7.5 months). It is emphasized that percutaneous needle aspiration is useful both for diagnosis and treatment of pyogenic liver abscess.Item A comparative study of low dose weekly paclitaxel versus cisplatin with concurrent radiation in the treatment of locally advanced head and neck cancers.(2009-01-14) Jain, R K; Kirar, P; Gupta, G; Dubey, S; Gupta, S K; Goyal, JPURPOSE: The purpose of this study was to compare low dose weekly paclitaxel versus cisplatin with concurrent radiation in locally advanced head and neck cancers. MATERIALS AND METHODS: From August 2005 to July 2006, a total of 100 biopsy proven, locally advanced head and neck cancers were enrolled for the study. All the patients were stratified in two groups, study group A and control group B. Study group patients received injection Paclitaxel 20 mg/m 2 , I/V 1 hr infusion weekly for 6 weeks and control group patients received injection Cisplatin 30 mg/m 2 , I/V 2 hrs infusion weekly for 6 weeks. All patients received 66-70 Gy concurrent radiation at the rate of 2 Gy/day, 5 #/week, in 6-7 weeks by cobalt theratron phoenix - 80 teletherapy units. RESULT: Complete response achieved in 73% of patients in study group and 64% of patients in control group. There was no statistically significant difference observed between the study group and the control group (chi2 = 1.167, df = 1, level of significance 0.05). On 3-10 months of follow-up 59% of patients in the study group and 42% of patients in the control group are alive and disease free. Local toxicities including mucositis, dysphasia and skin reactions were more in the study group but tolerable. CONCLUSION: Efficacy of paclitaxel in low dose weekly schedule is comparable to cisplatin in locally advanced head and neck squamous cell carcinoma. Further analysis and follow-up are needed to evaluate if this benefit will translate into prolonged survival.Item Copper as a male contraceptive.(1981-12-01) Riar, S S; Khanna, S D; Nayar, H S; Parshad, R; Jain, R K; Kain, A K; Bhat, K SItem Cryoglobulins in infective endocarditis: correlation with organ involvement.(1986-07-01) Jain, R K; Malaviya, A N; Bansal, R; Kumar, A; Tiwari, S C; Bhuyan, U NItem Depression in geriatric population in urban slums of Mumbai.(2007-04-05) Jain, R K; Aras, R YA community based study was conducted in an urban slum of Mumbai to assess the epidemiological factors associated with geriatric population and depression. A sample size of 196 was taken according to Lots quality technique, including all elderly above 60 years of age in the study area. Depressed elderly (using Geriatric Depression Scale) constituted 45.9% of the study population and was more in females (57.8%, p < 0.05). The significant variables associated with depression were poor socio-economic status, marital status, non-working or dependency and illiteracy (p < 0.05). Depressed elderly were more inclined towards substance abuse (58.13%), had disturbed sleep patterns (61.6%) and mostly suffered from acute/chronic illness (p < 0.05).Item Detection of paracetamol in skin tissue by GC-MS: A case study.(2005-06) Jain, R K; Jayshanker, G; Sarin, R KA 13 year-old child suffered an anaphylactic reaction to a drug combination and died in the clinic. The Investigating Officer collected an assortment of drugs and injection vials from the clinic and forwarded them along with the injection site of the victim's skin and some viscera to the laboratory for examination. At the laboratory, the samples were subjected to chemical and chromatographic analysis. After extracting the drug from the biological samples, TLC was done using a new solvent system, which improved the separation of drug from the matrix. A gas chromatographic-mass spectrometric (GC-MS) method devised for the determination of paracetamol residue in skin tissues was done. This method allows for detection of residual drug in biological tissues by using single-ion monitoring, and confirmation by a full scan electron impact (El) mass spectrum. Paracetamol was extracted with ether/chloroform from the samples after acidic and basic extraction procedures, cleaned up and washed, followed by partition between chloroform. The cleaned up extract was injected into the GC-MS, and detection was done using single ion monitoring at m/z 109.Item Development and validation of a Hindi language health-related quality of life questionnaire for melasma in Indian patients.(2016-01) Sarkar, Rashmi; Garg, Shilpa; Dominguez, Arturo; Balkrishnan, Rajesh; Jain, R K; Pandya, Amit GBackground: Melasma, which is fairly common in Indians, causes signifi cant emotional and psychological impact. A Hindi instrument would be useful to assess the impact of melasma on the quality of life in Indian patients. Objective: To create a semantic equivalent of the original MELASQOL questionnaire in Hindi and validate it. Methods: A Hindi adaptation of the original MELASQOL (Hi-MELASQOL) was prepared using previously established guidelines. After pre-testing, the Hi-MELASQOL questionnaire was administered to 100 women with melasma visiting the out-patient registration counter of Safdarjung Hospital, Delhi. These women were also administered a Hindi equivalent of the Health Related Quality of Life (HRQOL) questionnaire. Melasma area severity index (MASI) of all the participants was calculated. Results: The mean MASI score was 20.0 ± 7.5 and Hi-MELASQOL score was 37.19 ± 18.15; both were highly, positively and signifi cantly correlated. Reliability analysis showed satisfactory results. Physical health, emotional well-being and social life were the most adversely affected life domains. Limitations: It was a single-center study and the number of patients studied could have been larger. Conclusion: Hi-MELASQOL is a reliable and validated tool to measure the quality of life in Indians with melasma.Item Epidemic dropsy: a study of cutaneous manifestations with histopathological correlation.(2001-07-01) Kar, H K; Jain, R K; Sharma, P K; Gautam, R K; Kumar, P; Bhardwaj, MClinical and histopathological features of epidemic dropsy were studied in 19 patients. Bilateral pitting pedal oedema, erythrocyanosis and tachycardia without fever were the predominant clinical features. Histology revealed deposition of hyaline material on the walls of dermal blood vessels.Item Epidemiological and clinical profile of irritable bowel syndrome in India: report of the Indian Society of Gastroenterology Task Force.(2008-01-11) Ghoshal, Uday C; Abraham, Philip; Bhatt, Chetan; Choudhuri, Gourdas; Bhatia, Shobna J; Shenoy, K T; Banka, N H; Bose, Kalyan; Bohidar, N P; Chakravartty, Karmabir; Shekhar, N Chandra; Desai, Nutan; Dutta, Usha; Das, Goutam; Dutta, Sangeet; Dixit, V K; Goswami, B D; Jain, R K; Jain, Sunil; Jayanthi, V; Kochhar, Rakesh; Kumar, Ajay; Makharia, Govind; Mukewar, Shrikant V; Mohan Prasad, V G; Mohanty, Alok; Mohan, A T; Sathyaprakash, B S; Prabhakar, B; Philip, Mathew; Veerraju, E Peda; Ray, Gautam; Rai, Ramesh Roop; Seth, A K; Sachdeva, Atul; Singh, Shivaram Prasad; Sood, Ajit; Thomas, Varghese; Tiwari, Shridhar; Tandan, Manu; Upadhyay, R; Vij, J CAIMS: To study the profile of irritable bowel syndrome (IBS), and the frequency of such symptoms among the general population, in India. METHODS: In this prospective, multi-center study, data were obtained from 2785 patients with chronic lower gastrointestinal symptoms (complainants) with no alarm feature and negative investigations for organic causes visiting physicians at 30 centers, and from 4500 community subjects (non-complainants), using separate questionnaires. RESULTS: Most complainants were middle-aged (mean age 39.4 years) and male (1891; 68%). The common symptoms were: abdominal pain or discomfort (1958; 70%), abdominal fullness (1951; 70%); subjective feeling of constipation (1404 of 2656; 53%), or diarrhea (1252 of 2656, 47%), incomplete evacuation (2134; 77%), mucus with stools (1506; 54%), straining at stools (1271; 46%), epigastric pain (1364; 49%) and milk intolerance (906; 32%). Median stool frequency was similar in patients who felt they had constipation or those who felt they had diarrhea. Information to subtype symptoms using standard criteria was available in 1301 patients; of these, 507 (39%) had constipation-predominant IBS ( 3 3 stools/day) and 744 (57%) had indeterminate symptoms. Among non-complainants, most subjects reported daily defecation frequency of one (2520 [56%]) or two (1535 [34%]). Among non-complainants, 567 (12.6%) reported abdominal pain, 503 (11%) irregular bowel, 1030 (23%) incomplete evacuation, 167 (4%) mucus and 846 (18%) straining at stools; a combination of abdominal pain or discomfort relieved by defecation, and incomplete evacuation was present in 189/4500 (4.2%) community subjects. CONCLUSIONS: Most patients with IBS in India are middle-aged men, and have a sense of incomplete evacuation and mucus with stools. Abdominal pain or discomfort is frequent but not universal. Importantly, stool frequency was similar irrespective of whether the patients felt having constipation or diarrhea. Most (90%) non-complainant subjects had 1 or 2 stools per day; symptoms complex suggestive of IBS was present in 4.2% of community subjects.Item Epidemiology and genetics of dilated cardiomyopathy in the Indian context.(2009-07) Ushasree, B; Shivani, V; Venkateshwari, A; Jain, R K; Narsimhan, C; Nallari, PratibhaBackground: Dilated cardiomyopathy (DCM) still remains to be a poorly understood and less analyzed group of cardiac-muscle disorders when compared to hypertrophic cardiomyopathy (HCM). Also, the vast clinical heterogeneity among the patients has rendered the small and isolated kindred studies less informative on the genetics and epidemiology of DCM. Aim of the study: The study aimed at understanding the epidemiology and genetics of DCMs in the Indian context. Materials and methods/ Statistical analysis: One hundred seven DCM patients and 105 healthy individuals were included in the study for epidemiological and genetic risk factor identification and to fit the possible mode of inheritance. Single's ascertainment methodology for segregation analysis and Penrose frequency estimates were followed to evaluate for the role of specific epidemiological factors in the disease etiology. Chi-square analysis was carried out to interpret the results statistically. Results and Conclusion: Our study suggests that epidemiological factors like gender, age at onset and vegetarian diet in conjunction with sarcomere gene mutations may play a role in the disease expression. Similarly, segregation analysis for the possible mode of inheritance showed a deviation from the autosomal dominant mode of inheritance, strengthening the underlying genetic heterogeneity of DCM.Item Ewing's sarcoma of rib presenting as paraplegia of acute onset (case report).(1979-11-01) Hazra, D K; Pursnani, M L; Agrawal, B M; Rohtagi, V K; Sharma, R D; Mahajan, A K; Jain, R K; Sharma, S KItem Great auricular nerve involvement in leprosy: scope for misdiagnosis.(2007-10-22) Ramesh, V; Jain, R K; Avninder, SThree patients with neuritis of the great auricular nerve (GAN) have been reported. Two patients seen by physicians and an otolaryngologist had prominent and tender cord along the neck with facial edema and history of fainting attack in one, and erythema and hyperaesthesia of the ear in the other simulating vascular occlusion, which were confirmed to be leprosy in Type 1 reaction by the dermatologist. In the third, cold abscess in the nerve that had persisted after anti-leprosy treatment was mistaken as tuberculous cervical lymphadenitis by a surgeon since aspiration had revealed acid-fast bacilli. The probable reasons for misdiagnosis include rarity of involvement of the GAN and its proximity to main blood vessels, and the need for careful interpretation of laboratory results.Item Histoid leprosy with ENL reaction.(2002-11-28) Sharma, Suresh K; Rath, Namita; Gautam, R K; Sharma, P K; Jain, R K; Kar, H KA 23-year old man presented with firm cutaneous and subcutaneous nodules of histoid leprosy. Some of the nodules suppurated after multidrug therapy (MDT) and these nodules showed features of erythema nodosum leprosum (ENL) on histopathological examination. ENL is a rare phenomenon observed in histoid leprosy.