Browsing by Author "Jain, M K"
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Item 9p-Syndrome.(1994-01-01) Boby, J; Karande, S C; Lahiri, K R; Jain, M K; Kanade, SA 2 1/2 month old male child was admitted with loose motions and mild dehydration. He was full term normal delivery, born of a non-consanguinous marriage. On examination, he had trigonocephaly; anteverted nostrils, long philtrum and hypoplastic supraorbital ridges. X-ray showed sutural separation. Karyotyping confirmed deletion of short arm of chromosome 9 distal to band p22.Item Acanthamoeba meningoencephalitis complicating pyogenic meningitis.(1991-07-01) Karande, S C; Lahiri, K R; Sheth, S S; Nadkarni, U S; Jain, M K; Shah, M DItem Alterations in metabolic activity of Cysticercus fasciolaris on some anthelmintic treatments.(1992-04-01) Jain, M K; Gupta, S; Katiyar, J C; Singh, S P; Srivastava, V MEffect of candidate compounds 81-470 i.e. methyl [5[4-(2-pyridinyl)-1-piperazinyl]carbonyl]-1H-benzimidazole-2-yl]- carbamate and 86-162 i.e. methyl-5(6)-(alpha-hydroxyphenyl methyl) benzimidazole-2-carbamate along with reference drugs mebendazole and praziquantel on energy metabolism of C. fasciolaris recovered from rats treated with single dose of 500 mg/kg, ip was investigated. All the drugs significantly lowered the rate of uptake of glucose and alanine by the parasite. Suppression in the formation of lactate, the major end-product, was also noticed. Nonetheless the ratio of lactate produced versus the substrates consumed was not substantially affected. The recovered cysticerci also possessed less glycogen and ATP compared to the normal parasites. Although the effects exerted by the drugs were of the identical nature, they significantly differed in the magnitude of their action. Mebendazole followed by praziquantel maximally affected all the above metabolic activities while 86-162 proved to be the weakest in action. The results suggest that the examined drugs exert their chemotherapeutic activity by interfering with uptake of glucose and alanine but do not significantly alter their catabolism.Item Anthelmintic profile of methyl 5(6)-(4-methylpiperidin-1-yl) carbonylbenzimidazole-2-carbamate in experimental helminthiases.(1990-05-01) Gupta, S; Khan, A M; Jain, M K; Katiyar, J C; Naim, S S; Singh, S K; Sharma, SBiological evaluation of methyl 5(6)-(4-methylpiperidin-1-yl) carbonylbenzimidazole-2-carbamate against Ancylostoma ceylanicum, Nippostrongylus brasiliensis, Syphacia obvelata, Hymenolepis nana, H. diminuta and Cysticercus fasciolaris in experimental animals is reported. The compound (mg/kg) causes 100% elimination of A. ceylanicum (25 x 1), N. brasiliensis (100 x 1), S. obvelata (50 x 1), H. nana (250 x 3) and C. fasciolaris (50 x 10). It was also effective against the developing larvae (L3, L4 and L5) of A. ceylanicum at a single oral dose of 100 mg/kg. Another study indicated that the compound elicits 100% response within 32 hr of drug administration. The drug is well tolerated and LD50 is greater than 4500 mg/kg.Item Antiphospholipid antibodies (APA) and cerebral stroke.(1993-01-01) Gharpure, V P; Desai, V G; Deshmukh, C T; Nadkarni, U B; Jain, M K; Shah, M DItem Aspirin-induced non-cardiogenic pulmonary edema.(2007-04-19) Jain, M K; Indurkar, M; Malviya, S; Kastwar, VItem Autoimmune hemolytic anemia--mixed type.(1991-03-01) Sheth, S S; Karande, S C; Nadkarni, V B; Lahiri, K; Jain, M K; Shah, M DItem Case of the month: Conjoined twins--craniopagus.(1979-08-01) Jain, M KItem Cerebrospinal dehydrogenases in central nervous system infections.(1991-04-01) Jain, M K; Shah, A; Rao, S R; Sheth, S SCerebrospinal fluid (CSF) dehydrogenases were studied in 42 controls, 23 children with pyogenic meningitis, 22 with tuberculous meningitis and 19 with encephalitis to assess their usefulness in differentiating between the different central nervous system infections. CSF-LDH and ICD activity was increased in CNS infections (p less than 0.0001), LDH being significantly higher (p less than 0.001) in pyogenic meningitis than in tuberculous meningitis or encephalitis. However, ICD activity was significantly different in each of these conditions (p less than 0.001). The dehydrogenase activity declined with subsequent clinical improvement, in all children with meningitis. A significant direct relationship was found between the enzyme activity and CSF protein content as well as total cell count. The 95% confidence interval confirms the utility of assaying CSF dehydrogenase activity to differentiate various CNS infections, thus improving the diagnostic ability.Item Chinese paralytic syndrome.(1996-04-01) Lalwani, S G; Karande, S C; Menon, J; Chaudhuri, A; Nadkarni, U B; Jain, M KItem Chronic pancreatitis in homocystinuria.(1995-04-01) Patil, R V; Kulthe, S G; Boby, K F; Karande, S C; Jain, M KItem Congenital lipodystrophy with defective leucocyte function (a case report).(1990-01-01) Kher, A S; Lahiri, K R; Jain, M K; Shah, M DA 6 1/2 year old female child with congenital lipodystrophy is being presented. The noteworthy feature in this case was the defective leucocyte function and its association with tuberculous pericardial effusion.Item Correlation between serotypes, enterotoxin production and presence of colonisation factor antigens (CFA) in E. coli isolates from acute diarrhoea in children.(1983-04-01) Iyer, L; Deshpande, C K; Kale, V V; Jain, M KItem Correlation of serum vitamin A and its transport protein (RBP) in malnourished and vitamin A deficient children.(1990-07-01) Jain, M K; Mehta, N J; Fonseca, M; Pai, N VEighty nine children were studied for retinol (vitamin A) estimation and its transport protein--retinol-Binding Protein (RBP). Serum levels of retinol, RBP and serum protein and albumin were found to be low in children with signs of vit. A deficiency irrespective of their nutritional status. Serum levels of retinol and RBP were risen significantly almost double, after the oral and parenteral administration of vitamin A. PEM interferes with hepatic synthesis of RBP and the release of RBP from the liver depends on vitamin A. Vitamin A is a limiting factor, the presence of which is required for the release of apo-RBP from the liver.Item Drug metabolism in Indian childhood cirrhosis.(1984-02-01) Misra, P K; Jain, M K; Kaul, R; Ali, B; Kaur, S; Bhargava, K PItem Efficacy of methyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2-carbamate, a metabolite of mebendazole, against developing forms of experimental helminth parasites.(1991-07-01) Gupta, S; Srivastava, J K; Jain, M K; Katiyar, J C; Singh, J; Bhakuni, D SMethyl 5(6)-(alpha-hydroxyphenylmethyl) benzimidazole-2- carbamate, a metabolite of mebendazole, was evaluated against metamorphic forms of Ancylostoma ceylanicum in hamsters, Nippostrongylus brasiliensis in rats and cysticercoids of Hymenolepis nana in grain beetles. The test compound offered better action than mebendazole except against H. nana cysticercoids where the activity of the compound and mebendazole was comparable, but was inferior to the standard cestodicidal drug, praziquantel. The results suggest that the action was better by ip route compared to per os route of drug administration.Item Electrocardiographic diagnosis of atrial infarction in aluminium phosphide poisoning.(1992-10-01) Jain, M K; Khanijo, S K; Pathak, N; Sharma, M; Binayake, PItem Embolic stroke in a child with idiopathic dilated cardiomyopathy.(1996-07-01) Karande, S C; Kulthe, S G; Lahiri, K R; Jain, M KAn eleven year old boy presented with sudden onset right-sided hemiplegia and ipsilateral lower facial weakness. Two-dimensional echo revealed the diagnosis of idiopathic dilated cardiomyopathy with multiple intracardiac clots. MRI scan of head showed infarctions in the area of caudate nuclei, putamen, brain stem and cerebellum. On anticoagulation therapy, all thrombi, except one, disappeared. The child died 2.5 months later due to resistant cardiac failure.Item Evaluation of an urban child welfare centre.(1978-08-01) Jain, M K; Mehta, R; Kulkarni, M; Purandare, S; Shah, M DItem Evaluation of clinical criteria for the management of acute diarrhea in infants and children.(1983-07-01) Jain, M K; Komawar, V; Vora, J N; Irani, S F; Kale, V V; Iyyer, L
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