Browsing by Author "Ikewuchi, Catherine C."

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    Phytochemical Composition and Biochemical Studies of the Aqueous Leaf Extracts of Brillantaisia guianensis P. beauv on Alloxan Treated Wistar Albino Rats
    (Science Domain International, 2019-10) Chinedu, Kalu E.; Onyeike, Eugene N.; Ikewuchi, Catherine C.
    The present study was carried out on the phytochemical composition and biochemical studies oftheleafextract ofBrillantaisia guinensis peuvon alloxan treated Wistar albinorats.The experimental rats were administered with 80mg/kgbodyweight of alloxan,viathetailvein.After five days treatment with alloxan, thetreatment with the extractscommenced. Extracts wereadministeredorallyat100,200and 300mg/kg bw(both tonormal andtreated rats) for twenty-one days.Metformin,which served as a standard drug was administered at50mg/kg. Chromatographicanalysisof thephytochemical content of the leaf extract, revealed the presence of flavonoids (30.7mg/100g), saponins(50.6mg/100g), phytosterol (6.22mg/100g), tannins (7.50mg/100g) and glycosides(29.3mg/100g). Comparedtotest and normalcontrol,the extractsdose-dependentlyand significantlylowered(P<0.05) plasmaglucose and triglycerides, during the experimental period. Thisstudy revealedthe presence of pharma cologically bioactive compounds inthelea fextract and showed that the leaf extract had a dose-dependent hypoglycemic and hypotriglyceridemic effect on the Wistaralbino rats. The findings suggest a likely protective role of the extracts against hyperglycemia and hypertriglyceridemia thereby useful in the treatment and management of diabetes mellitus, obesity and other related cardiovascular diseases.