Browsing by Author "Hiremath, A."

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    Formulation And Comparative Evaluation Of Ondansetron Hydrochloride Mouth Dissolving Tablets In India
    (Innovare Academic Sciences Pvt. Ltd., 2019-09) Raheem T., A.; Singh, R.; Hiremath, A.; Nayak N., S.; Kamath K. S., S.
    Objective: The aim of the present study was to prepare the ondansetron hydrochloride Mouth Dissolving Tablets (MDTs) followed by its comparison with ethical and non-ethical (generic) marketed tablets. Methods: Prior to the formulation, drug excipient compatibility study was carried out by FTIR spectroscopy. The λmax was determined by UV spectroscopy. The ondansetron hydrochloride MDTs were prepared by direct compression method using Sodium Starch Glycolate (SSG) as super disintegrant and camphor as a sublimating agent. Then the prepared MDTs were subjected to evaluation of post compression parameters such as thickness and diameter, weight variation, wetting time, hardness, friability, disintegration and dissolution. The results obtained were compared with that of ethical and non-ethical marketed ondansetron hydrochloride 4 mg tablets. Results: The λmax was found at 310 nm. FTIR study revealed that excipients used in the prepared formulations are compatible with the drug. The thickness and diameter was in the range of 2.646 to 3.27 mm and 6.0 to 8.12 mm, respectively. Friability was in the range of 0.43 to 0.88 % and had a slightly higher friability (1.27%) for sublimated tablets. Wetting time and disintegration time were in the range of 15 to 40 sec and 23 to 50 sec, respectively. The 100 % drug release was found within 180 sec for all the codes. These results were then compared with non-ethical film coated ondansetron marketed tablets. Conclusion: Ondansetron hydrochloride MDT 4 mg tablets prepared in the laboratory were under specified IP limits. The experimental findings demonstrated that any of these ethical and non-ethical tablets of ondansetron hydrochloride can be selected, advised by the physician or pharmacist, as per the patient’s need and economical status.
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    An observational study of association of thyroid dysfunction and heart failure in a tertiary care centre
    (Medip Academy, 2024-06) Hiremath, A.; Barge, V.; Bafna, V.; Paritekar, A.
    Background: Heart failure (HF) is becoming leading problem in world now a days. Thyroid hormone has been proven to influence physiologic functions of cardiovascular system in many ways. HF presents a clinical challenge, with thyroid dysfunction emerging as a significant comorbidity, affecting prognosis and management. Approximately 22% of patients with HF have been demonstrated to have thyroid dysfunction. Clinical studies were confirmed that the patients with sub-clinical hypothyroidism had high risk of cardiovascular disease due to increased low density lipoprotein, elevated homocystein, hypercoagulative blood. In this study, we aim to evaluate association between sub-clinical hypothyroidism and HF to know its clinical significance. Methods: An observational study conducted over three months on 70 diagnosed HF patients admitted in tertiary care hospital, evaluating history, clinical profile and demographics, HF types, comorbidity, and screened for thyroid function. Results: Thyroid dysfunction prevalence among HF patients was 27.14%, with subclinical hypothyroidism being most common. Treatment led to significant improvements in symptoms and cardiac function. Conclusions: There is significant correlation between thyroid dysfunction and HF with Subclinical hypothyroidism can be independent risk factor for HF. Timely and early recognition and management of thyroid dysfunction in HF patients are crucial for prognosis enhancement. Early intervention holds promise for improved outcomes in HF management.