Browsing by Author "Gupta, M M"
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Item Abdominoscrotal hydrocele.(1977-05-16) Gupta, M MItem Absorption studies of iron and vitamin B12 by INMAS whole body counters.(1973-01-01) Gupta, N K; Bhola, G C; Gupta, S; Kalra, K; Gupta, M MItem Acute cerebellar ataxia in adults (report of two cases).(1986-04-01) Gupta, M M; Dang, H SItem Alkaptonuria (a case report).(1986-07-01) Sachdeva, J R; Gupta, M M; Jindal, V KItem An analysis of 500 cases of head injury in children.(1976-07-01) Ghooi, A M; Khanna, T; Gupta, M MItem Aspirin and clopidogrel resistance-a myth or reality: an update.(2008-05-26) Gupta, Sanjiv; Gupta, M MItem Calcium imbalance in hypoparathyroidism.(1991-08-01) Gupta, M MExtracellular fluid calcium is a tightly controlled variable. Hypoparathyroid state may result in profound calcium imbalance and moderate to severe hypocalcaemia. During 1974-89, 108 cases of hypoparathyroidism (97 post-surgical and 11 idiopathic) were seen. In the post-thyroidectomy group, 83 cases (85%) presented with acute transient hypocalcaemia with spontaneous recovery within 7-10 days. Chronic hypoparathyroidism was seen in 25 cases (14 post-surgical and 11 idiopathic). Convulsions resembling epileptic fits were seen in 9 cases (36%). Pseudopapilloedema was seen in three cases presenting with fits. The administration of phenobarbitone and dilantin aggravated convulsions in 9 patients. The other manifestations were psychiatric illness, cataract and calcification of basal ganglion. Biochemical findings included persistent hypocalcaemia with normal or raised serum phosphorus and lowered daily urinary excretion of calcium. Twenty three of 25 chronic hypoparathyroid cases were treated with vitamin D3 (1-3 mg/day) and calcium supplements (600-1000 mg/day)while 1 alfa-calcidol or calcitriol was used in two patients. Four patients receiving treatment with vitamin D3 developed transient hypercalcaemia with raised plasma levels of 25 hydroxy-vitamin D3. They responded to a reduction in dosage of vitamin D3. One patient was later changed over to 1-alfa-calcidol and another to calcitriol.Item Cholecalciferol--a vitamin or hormone.(1981-08-01) Gupta, M M; Kuppuswamy, GItem Clinical profile of connective tissue diseases in a referral service hospital.(1988-10-01) Jagadhish, T K; Kasthuri, A S; Chopra, A; Gupta, M M; Kumaravelu, S; Dham, S K; Bhalla, I P; Uberoi, H SItem A clinical study of adult leukaemias.(1990-06-01) Kasthuri, A S; Jaiprakash, M P; Panicker, N K; Gupta, M M; Rajoor, G S; Basu, S K; Sambandam, S; Bhalla, I PThe incidence of adult leukaemias, their response to therapy and the complications of therapy were studied in 121 cases over seven years (1981-1987). All cases were followed up till recovery or death for periods ranging from seven days to seven years. Adult leukaemias accounted for 2.56% of all admissions due to malignancies. There were 21 cases of acute lymphoblastic leukaemia, 61 of acute myelogenous leukaemia, 36 of chronic myelocytic leukaemia and 3 chronic lymphocytic leukaemia. All received aggressive combination chemotherapy. Remission could be achieved in 57% to 60% of cases. Infection (34%), bleeding (34%), and central nervous system involvement (25%) were the complications during therapy. The cause of death was ascertained in 87 of 90 deaths by a detailed postmortem. Haemorrhage (34.5%), infection (31%) and uncontrolled leukaemia (22%) were the leading causes, either singly or in combination. Some of the uncommon causes of death were fulminant hepatic failure, coronary artery disease, gangrene of the colon and disseminated tuberculosis.Item Coarctation of aorta and hereditary spherocytosis.(1995-09-01) Kaur, K; Vij, A; Gupta, M M; Kumar, AItem Detection of carcinogens by microsomal degranulation employing Sepharose 2B Gel filtration.(1982-10-01) Gupta, R; Dani, H M; Gupta, M MItem Detection of mutagenicity in cervico-vaginal secretions--a plausible risk factor for cervical cancer.(1990-07-01) Parashari, A; Gupta, M M; Singh, V; Bhadola, P; Luthra, U KThe cervico-vaginal secretions from 51 women with various grades of dysplastic lesions of uterine cervix were assessed for mutagenic potential by Ames test using histidine deficient mutant strain of Salmonella typhimurium TA-98: with S-9 mix. Twenty three per cent of samples from women with cervical dysplasia were found significantly positive (P less than 0.001) for mutagenic activity compared to 3% positive from control. The frequency of mutagenic secretions detected were almost uniform, irrespective of the severity of cervical lesions. None of cervico-vaginal secretions, positive for mutagenicity could revert the tester strain when tested in absence of S-9 mix (liver microsomal enzymes). This indicates that mutagens in cervico-vaginal secretions are effective only when activated enzymatically.Item Early pre-diabetic hormonal changes in diabetes mellitus--their significance.(1992-11-01) Gupta, M M; Anand, A CItem Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine.(2011-11) Gupta, M M; Patel, Mitul G; Kedawat, MadhulikaMotion sickness is a very common disturbance of the inner ear that is caused by repeated motion such as from the swell of the sea, the movement of a car, the motion of a plane in turbulent air, etc. Most medications for motion sickness need to be taken at least 30 minutes prior exposure to the activity that can cause the problem. This project is based on the hypothesis that Mouth Dissolving Films (MDF) are rapidly dissolving dosage forms which when placed in the mouth release the drug immediately. These dosage forms would be preferred by pediatric and geriatric patients since these are not associated with fear of choking. The fast dissolving films prepared by solvent casting method with suitable appearance, mechanical strength, peelability and disintegration time were obtained using Methocel E-5 as a primary film former. Meclizine HCl, a poorly water soluble and bitter drug could be successfully incorporated in the fast dissolving films with the help of solubilizers such as β-Cyclodextrine and PEG-400.Item Heparin induced thrombocytopenia.(2008-08-05) Gupta, S; Gupta, M MHeparin induced thrombocytopenia (HIT) is a serious and life endangering complication of heparin therapy. It usually occurs after 5-14 days of continuous heparin therapy. It is immune mediated. Heparin, in the affected individual binds with platelet factor 4 (PF-4) and forms a highly antigenic Heparin PF-4 complex which leads to the generation of specific IgG Heparin PF4 antibodies (also called HIT antibodies). HIT antibodies may activate the platelets via Fcy receptor causing the release of highly coagulable micro particles which promote thrombosis--both venous and arterial. However, all patients with HIT antibodies do not progress to HIT with thrombosis (HITT). HIT can present as asymptomatic thrombocytopenia. It can also present with alarming features of venous and/or arterial thromboembolism, for example, pulmonary embolism from deep vein thrombosis (DVT), limb gangrene warranting amputation, cerebrovascular attack (CVA) or myocardial infarction (MI). Rare manifestation of HIT includes necrotizing skin lesion, acute anaphylactoid reaction following IV heparin bolus and acute adrenal apoplexy due to massive adrenal vein thrombosis. The diagnosis is based upon the combination of unexplained thrombocytopenia, demonstration of HIT antibodies, clinical profile and outcome of the case following withdrawal of heparin and administration of non-heparin anticoagulant like Lepirudin, Argatroban or Danaparoid. The choice of alternative anticoagulant depends upon the availability, cost, monitoring facilities and administrative guidelines.Item Human leucocyte antigen and insulin dependent diabetes mellitus.(1991-07-01) Gupta, M M; Raghunath, D; Kher, S K; Radhakrishnan, A PHLA typing was done in 25 cases of insulin dependent diabetes mellitus (IDDM) and compared with 60 healthy controls. There was a significantly increased frequency of HLA B-8, HLA B-12 and HLA DR-3 in IDDMO. The odds ratio (relative risk) of developing IDDM for HLA B-8 was 4.42 (p less than 0.10), for HLA B-12 was 3.56 (p less than 0.10) and for HLA DR3 9.75 (p less than 0.001). There was no correlation of HLA specificity with complications of diabetes.Item Hypercalcaemia of malignancy.(1981-01-01) Gupta, M M; Singh, H; Christian, SItem Hyperlipidaemias and vascular complications of diabetes mellitus.(1979-06-01) Suri, R K; Gupta, M M; Chakravarti, A KItem Hypertension in diabetes mellitus.(1993-07-01) Gupta, M M
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